Vitamin E
104 associated posts. These are attributed summaries; original text remains at the linked X post and in the local archive.
- @lowmegatron · 2025-10-02 original
The author claims vitamin E can ease asthma by blocking harmful byproducts formed when polyunsaturated fats interact with bacterial endotoxin. They say it acts on the same pathways as some asthma drugs.
Source summary and thread relationship - @lowmegatron · 2025-10-02 original
The post quotes Ray Peat saying alcohol served to him acted as an antidote to allergens that would otherwise make him sick, with antioxidant effect he compares to vitamin E. The embedded lowmegatron post claims low-dose alcohol increases glymphatic drainage in mice and that light drinkers have lower depression and dementia risk.
Source summary and thread relationship - @lowmegatron · 2025-10-03 original
Author claims bacterial endotoxin drives cognitive impairment and that vitamin C deficiency worsens gut barrier integrity and endotoxin handling. Vitamin C is said to help protect against endotoxin effects, including in mice. The author also says vitamin C supports vitamin E recycling and lowers lipid peroxidation from polyunsaturated fats.
Source summary and thread relationship - @lowmegatron · 2025-10-09 original
Author cites a case-control study abstract reporting about 2x thyroid cancer risk associated with dental X-rays, and adds a sarcastic remark that X-rays were once called safe and are now safer because doses are lower. The quoted post relays Ray Peat's views on avoiding unnecessary X-rays and on nutrients, hormones, coffee and red light as protective around X-rays.
Source summary and thread relationship - @lowmegatron · 2025-10-12 original
The author lists substances and practices that he claims lower or block serotonin, including aspirin, L-theanine, thiamine, glycine, taurine, T3, ginger, cyproheptadine, vitamin E, magnesium, DHEA, progesterone, testosterone/DHT, lysine, and avoiding seed oils. The quoted context is a Ray Peat line about serotonin overproduction and hibernation.
Source summary and thread relationship - @lowmegatron · 2025-10-14 original
The post quotes Ray Peat saying the skin test for iodine deficiency is unscientific because reductants convert iodine to colorless iodide. The embedded quoted post from lowmegatron quotes text linking excess iodide to autoimmune thyroiditis and adds a bracketed comment about selenium, vitamins C and E, and polyunsaturated fats.
Source summary and thread relationship - @lowmegatron · 2025-10-16 original
The author lists supplements, foods and habits they say protect against polyunsaturated fat (PUFA) and seed oil effects. The lists cover reducing lipid peroxidation, lowering free fatty acids and supporting glucuronidation and sulfation. The author also advises eating mostly saturated fats and avoiding high-PUFA oils. The embedded lowmegatron post has an overlapping saturated fat/PUFA list plus a note on olive oil.
Source summary and thread relationship - @lowmegatron · 2025-10-23 original
Author claims negative ion generators lower serotonin and histamine, and that oceans and waterfalls naturally produce negative ions. Bullets and a Ray Peat quote say positive ions raise serotonin and negative ions reduce brain serotonin and histamine. The embedded lowmegatron post lists substances and practices said to lower or block serotonin.
Source summary and thread relationship - @lowmegatron · 2025-11-06 original
The post shares a Ray Peat quotation on minimizing the harmful effects of serotonin through diet, light and specific agents. The quoted lowmegatron post lists compounds and practices said to lower or block serotonin.
Source summary and thread relationship - @lowmegatron · 2025-11-09 original
The author lists claimed effects of high prolactin, its claimed causes (stress, serotonin, hypothyroidism, low zinc, seed oils, etc.) and things he says may lower it (zinc, DHT, coffee, aspirin, bright light, progesterone, thyroid optimization, etc.).
Source summary and thread relationship - @lowmegatron · 2025-11-10 original
The post quotes Ray Peat saying serotonin reuptake inhibitor antidepressants increase prolactin and were found to cause osteoporosis after prolonged use. The embedded lowmegatron post lists symptoms attributed to high prolactin, causes of high prolactin, and factors said to lower it.
Source summary and thread relationship - @lowmegatron · 2025-11-11 original
The post claims aspirin can boost dopamine and may help in Parkinson's. It says aspirin increases tyrosine hydroxylase, which is needed to make dopamine, and that this was shown in lab-grown brain cells and live mice. The embedded lowmegatron post lists substances and practices claimed to lower or block serotonin.
Source summary and thread relationship - @lowmegatron · 2025-11-12 original
The author claims polyunsaturated fats such as linoleic and arachidonic acid interfere with vitamin D binding to DBP, while saturated fats do not. The embedded lowmegatron post lists strategies to protect against seed oils and polyunsaturated fats, including supplements, foods and fats to eat or avoid.
Source summary and thread relationship - @lowmegatron · 2025-11-13 original
The post quotes Ray Peat saying he seldom recommends oral supplements because of contaminants, except aspirin dissolved in warm water. He uses vitamin D on the skin in oil in winter, and says fat-soluble vitamins absorb through skin at roughly 5%. He also says water-soluble vitamins absorb poorly but can be absorbed significantly over a large area. The embedded lowmegatron post quotes Peat on winter vitamin D from milk, liver, vitamin D oil on skin and occasional ultraviolet light.
Source summary and thread relationship - @lowmegatron · 2025-11-21 original
Author lists conditions said to be caused by bacterial endotoxin entering the bloodstream in leaky gut, then lists nutrients, drugs, foods and lifestyle factors said to reduce endotoxin or its inflammatory effects. The embedded post claims pregnenolone curbs alcohol cravings partly through TLR4 inhibition.
Source summary and thread relationship - @lowmegatron · 2025-11-22 original
Author describes a case report of a woman whose manic symptoms after gastrectomy for obesity reportedly resolved within two weeks on 1 g/day activated charcoal, with a quoted mechanism proposing a brain–gut axis. The embedded lowmegatron post claims bacterial endotoxin from leaky gut causes many conditions and lists interventions said to help with endotoxin.
Source summary and thread relationship - @lowmegatron · 2025-11-24 original
The author claims that reducing excess iron lowers cancer risk, citing reductions in cancer deaths, incidence and all-cause mortality (PMID 18612130). They say iron promotes lipid peroxidation of PUFAs. They quote Ray Peat's advice on vitamin E, coffee, unsaturated fats, vitamin C and copper in relation to iron. The embedded lowmegatron post claims coffee protects DNA by lowering lipid peroxidation, citing a randomized study.
Source summary and thread relationship - @lowmegatron · 2025-11-25 original
The author claims much mental illness begins in the gut because bacterial endotoxin poisons mitochondria and leaky gut lets more endotoxin into circulation. They quote a systematic review and meta-analysis on gut dysbiosis markers in severe mental illness and chronic fatigue. They then list nutrients, foods and other factors they say reduce endotoxin or endotoxin-driven inflammation.
Source summary and thread relationship - @lowmegatron · 2025-11-26 original
The author lists nutrients, foods and other factors they say can help with high histamine, including correcting hypothyroidism and estrogen dominance. The embedded post from lowmegatron introduces a thread on histamine hacks and lists conditions in which histamine is implicated.
Source summary and thread relationship - @lowmegatron · 2025-11-26 original
The posting author argues that seed oil (linoleic acid) intake probably plays a large role in Hashimoto's susceptibility, citing a rodent study where a high-linoleic-acid diet was followed by thyroid autoimmunity and hypothyroidism. The author links this to lipid peroxidation and says seed oils are tied to other autoimmune diseases partly via pro-estrogenic properties. The embedded quoted post (lowmegatron) cites register data on suicide and unknown-cause death in Hashimoto's and gives that account's opinion that inadequate treatment, T3 and temperature are involved.
Source summary and thread relationship - @lowmegatron · 2025-11-26 original
The post claims that lowering iron, via phlebotomy, reduces insulin resistance in people with NAFLD, quoting a paper. The author adds a mechanism: iron plus seed oils creates a pro-oxidative environment that forms lipid peroxides such as 4-HNE and damages mitochondria and insulin signaling. The embedded quoted post (lowmegatron) cites iron reduction and lower cancer risk and includes a Ray Peat quote on iron, vitamin E, coffee, vitamin C and copper.
Source summary and thread relationship - @lowmegatron · 2025-11-26 original
The post quotes a Ray Peat Q&A saying age spots may be caused by high estrogen or polyunsaturated fats, and suggests reducing PUFAs, using vitamin E orally or topically, and topical niacinamide for sun-induced spots. The author adds that PUFAs are found in seed oils, fish oils, pork and poultry fat, and quotes a case report on vitamin E deficiency and lipofuscin.
Source summary and thread relationship - @lowmegatron · 2025-11-29 original
The post claims rosacea and other skin conditions are often due to gut events, citing a Ray Peat quote on bacterial endotoxin and a case report of rosacea remission after reduced bowel transit time. The embedded quoted post (lowmegatron) lists conditions attributed to endotoxin from leaky gut and a long list of substances said to help with endotoxin.
Source summary and thread relationship - @lowmegatron · 2025-11-30 own thread
lowmegatron claims endotoxin-induced "sickness behavior" can be reduced by vitamin E (alpha-tocopherol). He quotes a mouse study in which endotoxin reduced social behavior at 4h and the lowest endotoxin dose's effect was blocked by alpha-tocopherol.
Source summary and thread relationship - @lowmegatron · 2025-11-30 own thread
lowmegatron claims COX inhibition and vitamin E improve endotoxin-induced mood and behavior problems largely by preventing the creation of inflammatory PUFA byproducts.
Source summary and thread relationship - @lowmegatron · 2025-11-30 own thread
lowmegatron claims fat-soluble vitamins D, A, E and K2 can help with endotoxin-related leaky gut, TLR4 activation, inflammation, cortisol and sickness behavior. He lists food sources and the personal regimen he follows (D3 4k IU in winter, K2 8 mg, vitamin E 200-800 IU, vitamin A 1700 ug), and adds that individual needs may differ.
Source summary and thread relationship - @lowmegatron · 2025-12-01 original
The author claims Wi-Fi and cell-signal EMF trigger lipid peroxidation, contributing to several diseases, and that zinc and vitamins C/E help protect cells; the author recommends distance. The embedded lowmegatron post links higher coffee intake to lower cirrhosis risk and lists proposed mechanisms.
Source summary and thread relationship - @lowmegatron · 2025-12-02 own thread
lowmegatron gives a list of claimed ways to lower serotonin. He says PUFAs, estrogen, vitamin E or B1 deficiency and elevated free fatty acids raise it. He says zinc, niacinamide, aspirin, creatine, gelatin/glycine, vitamin E, vitamin D, L-theanine, inosine, coffee with food, calcium, magnesium, aged cascara sagrada, quinine, lysine and ginger lower it or help. He names antiserotonin drugs lisuride, cyproheptadine, memantine and famotidine.
Source summary and thread relationship - @lowmegatron · 2025-12-02 own thread
lowmegatron says vitamin E has anti-estrogen and anti-PUFA effects. He quotes findings that vitamin E lowered prolactin in uremic hemodialysis patients and inhibited pituitary hypertrophy in vitamin E-deficient rats, noting 300 mg/day for eight weeks.
Source summary and thread relationship - @lowmegatron · 2025-12-03 original
The author says vitamin C supplementation lowered TSH and improved symptoms in people on levothyroxine, citing a small proof-of-concept study. The author also says vitamin C may aid levothyroxine absorption and protect the thyroid from lipid peroxidation. The author personally thinks whole-food vitamin C is safer. The embedded quote is a Ray Peat statement on TSH.
Source summary and thread relationship - @lowmegatron · 2025-12-10 original
The author claims probiotics can cause brain fog, bloating and SIBO, that people may be unknowingly harming themselves, and that antibiotics are sometimes needed. The author quotes a study abstract (PMID 29915215) describing brain fog with SIBO and D-lactic acidosis that improved after stopping probiotics and using antibiotics. The embedded quoted post from lowmegatron links vitamin C deficiency, endotoxin and cognitive impairment.
Source summary and thread relationship - @lowmegatron · 2025-12-11 original
The post quotes Ray Peat on accumulated unstable fats making endotoxin exposure more inflammatory and stressing the lipid-rich brain with age. The embedded quote, from lowmegatron, lists conditions attributed to endotoxin from leaky gut and a long list of nutrients, drugs and habits said to help.
Source summary and thread relationship - @lowmegatron · 2025-12-11 original
The author argues that oxidized LDL drives atherosclerosis and related cardiovascular events, and that linoleic acid from seed oils is oxidized by lipid peroxidation, which hypothyroidism increases. The post quotes Ray Peat on Broda Barnes' rabbit work and thyroid supplementation, plus excerpts from two papers on LDL oxidizability and thyroid function. The embedded quote, from lowmegatron, claims raised blood free fatty acids cause inflammation and impair artery dilation.
Source summary and thread relationship - @lowmegatron · 2025-12-17 original
The author argues that some hypothyroidism is reversible with iodine restriction and that excess iodine is as harmful as deficiency. They cite a study in which 12 of 22 patients became euthyroid after 3 weeks of iodine restriction, and in which reintroducing 25 mg iodine daily made them hypothyroid again. They add Ray Peat and a review on excess iodine and autoimmune thyroiditis. They say selenium or vitamin E reduce the risk but do not fully prevent it. The embedded post from lowmegatron covers iodine intake and hypothyroidism rates in Japan and risk factors for iodine-induced thyroid dysfunction.
Source summary and thread relationship - @lowmegatron · 2025-12-19 original
The author argues that vitamin E supports immune function in aging, citing mouse pneumonia and influenza data and a human study of elderly subjects. The proposed mechanism is partial reversal of age-related T cell decline. The author says they take 200 IU of natural tocopherols and tocotrienols and that synthetic alpha-tocopherol should be avoided. The quoted lowmegatron post says cortisol shrinks the thymus.
Source summary and thread relationship - @lowmegatron · 2025-12-22 original
Post states vitamin E prevents calcium oxalate kidney stones by lowering lipid peroxidation. It supports this with a quoted excerpt (PMID 15963133) on hyperoxaluria-induced peroxidation and vitamin E treatment. The quoted post (lowmegatron) says coffee lowers kidney stone risk by about 10% per 8 oz.
Source summary and thread relationship - @lowmegatron · 2025-12-22 original
Post is a Ray Peat quotation giving a historical account of vitamin E research. Peat says vitamin E's anti-estrogenic action was reframed as an antioxidant effect, which fed the free-radical theory of aging. He also says polyunsaturated fats cause lipofuscin formation and degeneration.
Source summary and thread relationship - @lowmegatron · 2025-12-22 own thread
lowmegatron says Shute's work used natural vitamin E from wheat germ oil and was later 'debunked' with synthetic dl-alpha tocopherol, which is not found in nature. The author names TocoVit by IdeaLabs as the closest match they know of. The author also says the screenshots come from comments on their Facebook page and were reposted with permission.
Source summary and thread relationship - @lowmegatron · 2025-12-22 original
The author cites a paper suggesting that stress-related high histamine combined with vitamin C depletion damages arterial endothelium and predisposes to atherosclerosis and myocardial infarction. The author lists agents said to help lower histamine, depending on context, and common causes of elevated histamine.
Source summary and thread relationship - @lowmegatron · 2025-12-27 original
The post shares Ray Peat's first-person account of reactions to synthetic vitamin C (relief from poison oak, then sore throats, bronchitis and sickness from manufactured ascorbic acid), contrasted with no symptoms from fruit juice. The quoted post summarizes a small proof-of-concept study in which vitamin C lowered TSH and improved symptoms in people on levothyroxine.
Source summary and thread relationship - @lowmegatron · 2026-01-06 original
The author lists common causes of elevated histamine (such as high estrogen, endotoxin, hypothyroidism and nutrient deficiencies) and conditions in which histamine is implicated. They list things that 'can help', including vitamin E, progesterone, lidocaine, magnesium, l-theanine, thiamine, DAO and vitamin C. The embedded quoted post from lowmegatron opens a thread on 'histamine hacks' and lists the same implicated conditions.
Source summary and thread relationship - @lowmegatron · 2026-01-15 original
Vitamin E inhibits histamine release from mast cells in asthma and allergic diseases. Embedded post by lowmegatron on histamine as cause of IBS pain; reducing fermentable fiber intake reduced pain and urinary histamine; histamine-lowering strategies via diet and H4 receptor blockade; Ray Peat dietary recommendations and antihistamine cyproheptadine for functional abdominal pain.
Source summary and thread relationship - @lowmegatron · 2026-01-23 original
Polyunsaturated fat-driven lipid peroxidation damages testicular function and fertility; protective measures include vitamin E, coconut oil, and antioxidants from citrus.
Source summary and thread relationship - @lowmegatron · 2026-02-02 original
Kelp capsules suppress thyroid function via excessive iodine intake, with mechanism of iodine-induced hypothyroidism. Embedded post details iodine restriction reversibility of hypothyroidism in some patients, lipid peroxidation role, and Ray Peat commentary on excess iodine toxicity and autoimmune thyroiditis.
Source summary and thread relationship - @lowmegatron · 2026-02-10 original
Author discusses older papers on vitamin E for restless leg syndrome and leg cramps, sharing a quoted case series by Ayres and Mihan reporting relief in 26 cases with 300-400 IU doses, and notes a follow-up study of 76 cases.
Source summary and thread relationship - @lowmegatron · 2026-03-04 original
Author provides historical narrative of iodine's identification (1812) and thyroid use (1816); embeds extensive quoted content on iodine's adverse effects, importance of caution, mechanisms of iodine-induced hypothyroidism, and the distinction between iodine deficiency and excess.
Source summary and thread relationship - @lowmegatron · 2026-03-09 original
Author lists micronutrients, macronutrients, and lifestyle factors (sleep, stress) claimed to optimize thyroid hormones and prevent T3 suppression. Quotes lowmegatron on cortisol's anti-thyroid mechanisms.
Source summary and thread relationship - @lowmegatron · 2026-03-17 original
Vitamins E and C intake associated with 30-50% reduction in fatty liver disease risk/severity. Both reduce lipid peroxidation. Combination (E 600 IU/day + C 500 mg/day) as effective as ursodeoxycholic acid prescription medication.
Source summary and thread relationship - @lowmegatron · 2026-03-21 original
Author cautions against altering template meanings when adding value. Shares embedded post by lowmegatron on iron reduction and cancer risk, citing Ray Peat quotations on iron, vitamin E, coffee, unsaturated fats, vitamin C and copper.
Source summary and thread relationship - @lowmegatron · 2026-03-25 own thread
The post text is only links. Its quoted post by lowmegatron lists claimed ways to address endotoxin, including cascara sagrada, minocycline, aspirin, cocoa, coffee, DHEA, ginger, glycine, sleep, naringenin, orange juice, pregnenolone, progesterone, probiotics, sugar, taurine, several vitamins, mushrooms and zinc, and notes PUFA-rich high-fat diets may raise endotoxin.
Source summary and thread relationship - @lowmegatron · 2026-03-26 original
Ray Peat and peer-reviewed evidence on role of thyroid hormone, magnesium, and vitamin E in muscle cramping via ATP preservation and retention. Magnesium supplementation (4.5 mg Mg Pidolate 3×/day) effective for menstrual cramps across 6 cycles with progressive symptom reduction.
Source summary and thread relationship - @lowmegatron · 2026-03-31 original
Ray Peat quoted on T4 effectiveness as antithyroid substance, thyroid's role in pregnenolone production, and cholesterol requirements. Embedded post discusses neurosteroids, pregnenolone and progesterone for memory and anxiety via intranasal administration.
Source summary and thread relationship - @lowmegatron · 2026-04-03 original
Compilation of Ray Peat quotations on lipid peroxidation, linking disturbances in fat metabolism and peroxidation of polyunsaturated fatty acids to multiple degenerative diseases including Alzheimer's, liver disease, retinal degeneration, epilepsy, and circulatory problems. Describes mechanisms involving mitochondrial dysfunction and inflammation.
Source summary and thread relationship - @lowmegatron · 2026-04-09 original
Ray Peat advises against topical application of fat-soluble vitamins or steroid hormones to testicles, citing risk to gonadal lipid environment. Recommends arms or legs as alternative application sites for DHEA, pregnenolone, and progesterone.
Source summary and thread relationship - @lowmegatron · 2026-04-15 original
Bacterial endotoxin (LPS) lowers both TSH and thyroid hormones, creating misleading thyroid test results. Multiple dietary and supplemental compounds may reduce endotoxin burden or its effects.
Source summary and thread relationship - @lowmegatron · 2026-04-25 original
Ray Peat quote recounting personal experience with moles: avoided direct application due to cancerization risk; reports observed shrinking of moles within days when applying progesterone or DHEA (in vitamin E) 1 inch away, with steady shrinking over 7-10 days. Also describes increasing T3 thyroid hormone dosing to maintain normal daytime temperature and elevated resting pulse (95 bpm), and soaking in epsom salts/baking soda/salt baths for mole acceleration.
Source summary and thread relationship - @lowmegatron · 2026-04-28 original
Ray Peat quote on aspirin's anti-inflammatory actions and broad metabolic benefits in context of polyunsaturated fat toxicity; shares earlier aspirin-NAFLD post.
Source summary and thread relationship - @lowmegatron · 2026-05-07 original
lowmegatron says high-dose vitamin E can cause bleeding by interfering with vitamin K-dependent clotting proteins, and that increasing vitamin K can help. He cites a case report of a man taking vitamin E for hair loss, along with NSAIDs, who developed coagulopathy. He suggests that above 400 IU, and certainly above 1,000 IU, may be high dose, depending on the person.
Source summary and thread relationship - @lowmegatron · 2026-05-14 original
Quoted Ray Peat anecdote: hangnails disappeared after getting progesterone on hands in lab accident, never returned; nested anecdote about mole changes with progesterone/DHEA and T3 dosing.
Source summary and thread relationship - @lowmegatron · 2026-05-14 original
lowmegatron compiles Ray Peat quotes saying that copper is crucial for hair and skin color and for oxygen use and energy, that excess iron can block copper absorption, that cytochrome oxidase is copper-dependent and is restored by red light, thyroid and progesterone, and that T3 increases copper absorption.
Source summary and thread relationship - @lowmegatron · 2026-05-29 original
Post claims saturated fats protect against alcoholic liver disease while seed oils (polyunsaturated fats) promote it. Cites Ray Peat quotation and presents randomized controlled trial showing saturated fat improved survival over unsaturated fat in severe alcoholic hepatitis. Explains mechanisms via lipid peroxidation, gut microbiota, and gut barrier integrity. Embedded post details a specific RCT comparing butter to soybean oil.
Source summary and thread relationship - @lowmegatron · 2026-06-01 original
Practical tips for lowering prolactin and serotonin through thyroid optimization, nutrient status, dietary fat composition, light exposure, supplements, and specific compounds; includes embedded quote on cyproheptadine mechanism for SSRI sexual dysfunction.
Source summary and thread relationship - @lowmegatron · 2026-06-03 original
Ray Peat quote on intestinal inflammation from infection and undigested starches causing endotoxin-driven insulin resistance; comprehensive list of dietary and supplement interventions claimed to reduce endotoxin and associated inflammation.
Source summary and thread relationship - @lowmegatron · 2026-06-09 original
Oxidative stress is increased in hypothyroidism. Vitamin E, C, and taurine reduce oxidative stress markers and protect thyroid from fluoride-induced damage. In rodents, taurine supplementation reduced MDA (lipid peroxidation marker) elevated by hypothyroidism.
Source summary and thread relationship - @lowmegatron · 2026-06-09 original
Iodine balance is critical in hypothyroidism; excessive iodine can cause or worsen thyroid dysfunction. Studies show iodine restriction normalizes TSH and increases free T4 in subclinical hypothyroidism. High intake defined as >1000 μg/day or urine iodine exceeding reference range (8.6–41.3 μmol/g creatinine). Antioxidants (selenium, vitamin C, E) reduce oxidative stress from excess iodine but do not eliminate risk. Some individuals tolerate high-iodine protocols; others develop hypothyroidism or hyperthyroidism rapidly (Wolff-Chaikoff effect, Jod-Basedow phenomenon).
Source summary and thread relationship - @lowmegatron · 2026-06-10 original
lowmegatron claims that fasting causes hair loss by increasing fat burning. He cites rodent research in which fasting raises stress hormones and lipolysis, and free fatty acids cause hair follicle stem cell apoptosis, which topical vitamin E prevented in mice. He also cites human follicle explant results and notes that dramatic weight loss is linked to telogen effluvium.
Source summary and thread relationship - @lowmegatron · 2026-06-10 own thread
lowmegatron describes a human RCT of 49 people, with time-restricted eating (18-hour fasts), calorie restriction and normal eating groups. He reports hair regrowth was 18% slower with fasting, with shorter and thinner hairs. He presents increased fat oxidation and oxidative stress as the cause of hair stem cell death, which topical vitamin E mitigated in mice.
Source summary and thread relationship - @lowmegatron · 2026-06-11 original
lowmegatron says vitamin E helped hair follicle stem cells survive fasting. The quoted earlier post cites rodent work in which fasting raises cortisol and epinephrine, lipolysis and free fatty acids, and the free fatty acids cause stem-cell apoptosis. It also cites topical vitamin E preventing this in fasted mice, and a human follicle explant model.
Source summary and thread relationship - @lowmegatron · 2026-06-15 original
Two clinical and animal studies: saturated fat (clarified butter) improved survival in severe alcoholic hepatitis patients versus unsaturated fat; saturated fat and vitamin E reversed experimental alcoholic liver injury in mice, while medium-chain triglycerides also reduced severity.
Source summary and thread relationship - @lowmegatron · 2026-06-16 original
Vitamin E protects thyroid by inhibiting oxidative stress and lipid peroxidation. Higher intake associated with lower subclinical hypothyroidism and thyroiditis risk in men; higher vitamin E status associated with lower TSH and higher T4 in Hashimoto's women.
Source summary and thread relationship - @lowmegatron · 2026-06-18 original
Ray Peat letter to editor on vitamin A toxicity myths and proposed mechanism via temporary thyroid suppression from unsaturated oils; claims historical rumors of vitamin A blindness were unsubstantiated and vitamin E protective role.
Source summary and thread relationship - @lowmegatron · 2026-06-24 original
Reports vitamin C and E efficacy for restless leg syndrome comparable to pharmaceutical treatments; cites studies showing 10-point IRLS score improvements and effectiveness at low doses including acerola powder.
Source summary and thread relationship - @lowmegatron · 2026-06-25 original
Extended Ray Peat quotation on sunlight, skin cancer, and melanoma, emphasizing melanoma's link to estrogen and estrogenic pollutants rather than sun exposure, and protective roles of antioxidants and saturated fats; embedded quote from Jimmy Dore on basal cell carcinoma mortality.
Source summary and thread relationship - @lowmegatron · 2026-06-26 original
Tocotrienols (vitamin E variant, not thyroid hormone) suppress mast cell degranulation and reduce histamine release in mice through suppression of protein kinase C (PKC) activity, reducing allergic dermatitis. Embedded quote discusses idiopathic urticaria, thyroid hormone supplementation effects on thyroid antibodies and allergies.
Source summary and thread relationship - @lowmegatron · 2026-07-01 original
List of compounds and conditions that lower or elevate histamine; embedded post by lowmegatron reporting personal experience with PEA for histamine symptoms and citing clinical/veterinary/animal evidence for PEA in mast cell disorders.
Source summary and thread relationship - @lowmegatron · 2026-07-03 original
lowmegatron says stinging nettles are a source of serotonin and histamine. He quotes text that nettle sting fluid contains formic acid, leukotrienes, acetylcholine, histamine and serotonin, with estimated serotonin per sting. The quoted parent lists things he says lower or raise histamine.
Source summary and thread relationship - @jamesbondwisdom · 2026-07-08 original
The author claims pumpkin seed oil, 400mg daily, raised hair count 40% vs 10% placebo in a 2014 double-blind trial, via 5-alpha reductase inhibition and androgen receptor effects, without affecting testosterone or sexual function. He also cites tocopherols, zinc and fatty acids, and suggests oral plus topical use, comparing with finasteride costs and side effects.
Source summary and thread relationship - @lowmegatron · 2026-07-10 original
Ray Peat quoted on nutrient needs during stress, including vitamins A, C, E, pantothenic acid, and minerals magnesium, calcium, potassium, zinc, and sodium for different stress stages. Embedded post by lowmegatron discusses thyroid hormone T3/T4 as anti-stress substances and their protective effect against stress-induced gastric ulcers in animal research.
Source summary and thread relationship - @lowmegatron · 2026-07-15 original
lowmegatron presents a case report, cited as 'Reversible Hair Loss due to Levothyroxine Overdose', of an infant with congenital hypothyroidism who developed diffuse non-scarring hair loss 15-20 days after starting levothyroxine. Hair regrew after the dose was reduced. The author concludes that overdose may cause hair loss. The author also gives a best-guess reading of the FT3 and FT4 levels because the assay ranges are not stated.
Source summary and thread relationship - @lowmegatron · 2026-07-15 original
Ray Peat anecdote: two moles appeared and grew during summer beer consumption, then shrank and disappeared when beer stopped; attributed to estrogen content. Embedded Ray Peat quote on topical progesterone/DHEA and increased T3 causing mole shrinkage, and epsom salt baths.
Source summary and thread relationship - @lowmegatron · 2026-07-20 original
Pregnenolone topical and oral application for anti-aging effects with mixed results. Ray Peat describes dramatic symptom resolution from pregnenolone during 1983 health crisis with multiple conditions (arterial inflammation, dental abscesses, asthma, migraines, colitis). Notes many pregnenolone products contaminated with estrogenic impurities; recommends BodyBalancedMind (UK) and mentions Raena as trusted brands.
Source summary and thread relationship - @lowmegatron · 2026-07-23 original
lowmegatron argues that extreme caloric restriction and intermittent fasting cause hair loss. In his account, stress hormones raise lipolysis, and free fatty acids and fat oxidation kill hair follicle stem cells. Topical vitamin E prevented this in fasted mice. He cites an 18% slower hair growth in a human trial of 18-hour fasting.
Source summary and thread relationship - @lowmegatron · 2026-07-25 own thread
Quotes Ray Peat saying that in degenerative disease, direct supplementation of protective substances plus protective vitamins (especially E) and minerals (especially magnesium) is more appropriate.
Source summary and thread relationship - @lowmegatron · 2026-07-25 own thread
Quotes Ray Peat claiming many women with abnormal Pap smears, including biopsy-indicated carcinoma in situ, returned to normal in two months on a diet with protein, magnesium chloride, vitamins A, E, C and B-vitamins, thyroid and progesterone as needed, and liver twice weekly.
Source summary and thread relationship - @lowmegatron · 2026-07-25 own thread
Quotes Ray Peat saying men diagnosed with scleroderma reported symptom regression with thyroid, magnesium, epsom salt baths, topical progesterone and vitamin E; he suspects mitochondrial CO2 removes calcium. The quoted context is the author's own post on making magnesium bicarbonate water from magnesium hydroxide and carbonated water.
Source summary and thread relationship - @lowmegatron · 2026-07-25 original
Adelle Davis quotation on calcium deposits in soft tissues: low dietary calcium worsens deposits; adequate calcium and magnesium necessary for improvement in arthritis, calcification disorders; vitamin E prevents calcium oxalate kidney stone formation through lipid peroxidation reduction. Supporting factors include calcium-to-phosphate ratio, vitamin D, magnesium, and vitamin K.
Source summary and thread relationship - @1immortals1 · 2026-08-05 original
Comprehensive explanation of astaxanthin's antioxidant mechanism and comparative efficacy versus other antioxidants, with mechanistic details of cell membrane spanning, and multiple health benefit claims with dose recommendations.
Source summary and thread relationship - @lowmegatron · 2026-08-11 original
Saturated fat, particularly clarified butter, improves survival in severe alcoholic hepatitis and reduces alcoholic liver disease. Saturated fat is resistant to peroxidation unlike polyunsaturated fat, reducing inflammation, improving gut barrier function, and preventing thyroid hormone interference.
Source summary and thread relationship - @1immortals1 · 2026-08-16 original
Explanation of how supplement softgels containing seed oils as carriers undermine health benefits by delivering large doses of inflammatory omega-6 alongside modest omega-3 or other actives; describes mechanisms through oxidized linoleic acid metabolites (OXLAMs), identifies affected supplement types, and recommends alternative carriers.
Source summary and thread relationship - @lowmegatron · 2026-08-17 original
Author quotes Ray Peat discussing crude vitamin E's stamina-increasing effect from long-chain saturated fats and waxy materials, later identified as policosanol, with discussion of Cuban research and historical suppression. Embedded quote discusses policosanol's upregulation of Klotho anti-aging protein in cancer cells.
Source summary and thread relationship - @lowmegatron · 2026-08-17 own thread
lowmegatron quotes conclusions from a study of wheat germ oil with conditioning exercise in middle-aged men. It reportedly improved treadmill endurance, cardiovascular measures, reaction speed and lowered systolic blood pressure, and did not depress BMR the way vitamin E is known to, producing a slight rise instead.
Source summary and thread relationship - @lowmegatron · 2026-08-20 original
Author argues creatine lowers lipofuscin (aging pigment from polyunsaturated fat damage) and discusses mechanisms involving antioxidants, diet composition, hormone ratios, and protein turnover, citing animal studies and quotes from Ray Peat on lipofuscin formation and proteolytic enzyme inhibition.
Source summary and thread relationship - @lowmegatron · 2026-08-26 original
Individual differences in alcohol response depend on thyroid activity; alcohol has antioxidant effects but can cause hypoglycemia and pro-oxidative effects. Polyunsaturated fat (PUFA) increases alcohol's oxidative damage through iron-fat reactions. Saturated fat (clarified butter/MCT) reverses alcoholic liver injury better than unsaturated fat through reduced lipid peroxidation and gut barrier tightening. Saturated fat is not peroxidizable and reduces PUFA peroxidation. Thyroid hormone aids liver regeneration.
Source summary and thread relationship - @lowmegatron · 2026-09-01 original
Iron destroys vitamin E in animal feed and caused female rat infertility; wheat germ oil (vitamin E source) reversed iron-induced sterility. Author attributes Ray Peat quote and includes embedded discussion of policosanols and crude vitamin E historical research.
Source summary and thread relationship - @lowmegatron · 2026-09-01 original
Anemia has multiple causes; hemolytic anemia from vitamin E deficiency is common in premature infants and responsive to vitamin E treatment. Iron supplementation alone may worsen hemolytic anemia if vitamin E deficiency is present because iron destroys vitamin E.
Source summary and thread relationship - @lowmegatron · 2026-09-01 original
Commercial laboratory animal diets in 1940s caused sudden neurogenic disease (tremors, forced movements, head retraction, weakness) in chicks due to iron salts destroying added vitamin E. Vitamin E supplementation (0.2mg alpha-tocopherol daily) prevented disease.
Source summary and thread relationship - @lowmegatron · 2026-09-02 original
Ray Peat quote: Thyroid tends to lower cholesterol by converting it into pregnenolone and other steroids. Embedded quote discusses pregnenolone's effects on skin aging and health; Ray Peat personal account of pregnenolone's dramatic symptom relief from inflammatory conditions and associated facial rejuvenation.
Source summary and thread relationship - @lowmegatron · 2026-09-03 original
List of interventions for high histamine including thyroid correction, DAO enzyme, micronized PEA, progesterone, B vitamins, magnesium, L-theanine, copper, vitamins C and E, low PUFA diet, and hypoglycemia avoidance; author notes context-dependent efficacy. Embedded quote details personal PEA experimentation with symptom reduction and extensive research on PEA mechanisms in mast cell modulation.
Source summary and thread relationship - @1immortals1 · 2026-09-04 original
Astaxanthin is the only antioxidant that spans both water-soluble and fat-soluble layers of cell membranes, protecting cells from both sides simultaneously; has 6000x antioxidant capacity vs vitamin C and 550x vs vitamin E; crosses blood-brain and blood-retinal barriers. Supports endurance, skin health, inflammation reduction, sperm quality, and eye/brain health.
Source summary and thread relationship - @lowmegatron · 2026-09-15 original
General health optimization guidance recommending 'basic' nutrient coverage before exotic interventions. Lists common deficient micronutrients: magnesium, potassium, selenium, vitamins D, C, E, K1/2, thiamine. Advises testing and dietary sources before supplementation. Cites foundational lifestyle: sunlight, sleep, walking. Embedded quote discusses interventions that lower thyroid antibodies.
Source summary and thread relationship - @lowmegatron · 2026-09-18 original
Critically ill patients received intravenous soybean oil (Intralipid 82-90% calories) for decades; SMOFlipid, available since early 2000s, reduces soybean oil to 27% of calories. SMOFlipid composition provided with added vitamin E and egg yolk phospholipid.
Source summary and thread relationship - @jamesbondwisdom · 2026-09-24 original
The author claims jojoba oil is a liquid wax ester resembling human sebum. It is said to dissolve sebum plugs, regulate oil production, deliver nutrients to the follicle, be non-comedogenic, and provide SPF 4 to 6. The post gives usage directions and price comparisons against scalp detox products.
Source summary and thread relationship - @1immortals1 · 2026-09-25 original
Vitamin D requires four cofactors (magnesium, vitamin K2, vitamin A, dietary fat) for proper activation and cellular function; 80% of vitamin D users lack cofactors resulting in normal blood levels with absent cellular effects; complete stack recommended.
Source summary and thread relationship - @jamesbondwisdom · 2026-09-27 original
The author claims argan oil has the highest vitamin E content of any plant oil and reduced hair breakage by 78% in 3 months in a clinical evaluation. Other claims: it repairs the hair cortex, protects from heat up to 230°C, reduces frizz, and supplies squalene. The post gives a usage routine, a price, and a comparison with salon treatments.
Source summary and thread relationship