Testosterone and Androgens
201 associated posts. These are attributed summaries; original text remains at the linked X post and in the local archive.
- @nootropicguy · 2025-10-02 original
Author lists a supplement stack, saying it will double testosterone in one month, with no supporting detail. The post ends with 'Do what you will with this information'.
Source summary and thread relationship - @nootropicguy · 2025-10-02 own thread
nootropicguy directs readers to a full thread on the ingredients in a testosterone-boosting product. He says it explains why the claimed boost is not surprising, and offers a discount code.
Source summary and thread relationship - @lowmegatron · 2025-10-06 original
The author says cocoa supports gut barrier integrity and lowers circulating endotoxin. The author lists conditions attributed to high endotoxin and quotes a finding of a 40% reduction in plasma endotoxin. The author advises choosing cocoa low in heavy metals. A PMCID is cited with a mouse emoji. The embedded post (lowmegatron) says metabolic endotoxemia causes obesity and diabetes in mice and humans.
Source summary and thread relationship - @lowmegatron · 2025-10-11 original
Author lists proposed antidepressant mechanisms of coffee. The embedded lowmegatron post says coffee intake is associated with lower melanoma risk and attributes skin cancer to lipid peroxidation of PUFAs from seed oils, pork and poultry fat rather than sun.
Source summary and thread relationship - @lowmegatron · 2025-10-12 original
Author presents mouse-study excerpts on Coca-Cola and Pepsi, reporting larger testes, higher serum testosterone and increased androgen receptor mRNA expression. The embedded quoted post links omega-6 intake to smaller testicles in young Spanish men.
Source summary and thread relationship - @lowmegatron · 2025-10-12 original
The author lists substances and practices that he claims lower or block serotonin, including aspirin, L-theanine, thiamine, glycine, taurine, T3, ginger, cyproheptadine, vitamin E, magnesium, DHEA, progesterone, testosterone/DHT, lysine, and avoiding seed oils. The quoted context is a Ray Peat line about serotonin overproduction and hibernation.
Source summary and thread relationship - @lowmegatron · 2025-10-13 original
The parent text only says '@CowsEatGrassBlg talks about this'. The embedded quoted post from lowmegatron cites a mouse study reporting that Coca-Cola and Pepsi increased testis mass, serum testosterone and androgen receptor mRNA expression.
Source summary and thread relationship - @lowmegatron · 2025-10-14 original
The author says aromatase inhibitors regenerate the thymus by reducing testosterone-to-estrogen conversion. They support this with a quoted passage on aging rats, which notes that testosterone alone probably does not explain age-related thymic atrophy. An embedded post by lowmegatron claims hypothyroidism shrinks the thymus and impairs immune function.
Source summary and thread relationship - @lowmegatron · 2025-10-15 original
The author promotes oysters for immunity on the claim that age-related relative zinc deficiency lowers immunity and that zinc acts as an aromatase inhibitor, which blocks estrogen-driven thymus loss. They quote two rodent-marked passages on zinc supplementation and estradiol-induced thymus shrinkage. The embedded post is lowmegatron's aromatase-inhibitor and thymus post.
Source summary and thread relationship - @lowmegatron · 2025-10-16 original
Author claims cortisol shrinks the thymus, lowering protective immunity and raising autoimmunity risk, with changes resembling aging, citing a quoted finding on lymphocyte loss after cortisol injection. The embedded post (lowmegatron) argues zinc, from sources like oysters, may protect the thymus and estrogen shrinks it.
Source summary and thread relationship - @lowmegatron · 2025-10-16 original
The author lists supplements, foods and habits they say protect against polyunsaturated fat (PUFA) and seed oil effects. The lists cover reducing lipid peroxidation, lowering free fatty acids and supporting glucuronidation and sulfation. The author also advises eating mostly saturated fats and avoiding high-PUFA oils. The embedded lowmegatron post has an overlapping saturated fat/PUFA list plus a note on olive oil.
Source summary and thread relationship - @lowmegatron · 2025-10-16 original
The author states that blocking the glucocorticoid receptor lowers glucose and insulin in obese, diabetic mice, and that receptor activation raises free fatty acids. They list interventions said to help lower cortisol. The embedded lowmegatron post quotes a suggestion that coffee's anti-diabetic effect involves inhibiting 11β-HSD1.
Source summary and thread relationship - @lowmegatron · 2025-10-18 original
The author claims hypothyroidism, including 'hidden' hypothyroidism with normal TSH and T4, lowers testosterone and raises prolactin in men. They say underfeeding and overtraining can downregulate T3. They describe mechanisms involving TRH, prolactin, GnRH, LH and STAR protein. The embedded lowmegatron post says stress causes hidden hypothyroidism that blood tests often miss.
Source summary and thread relationship - @lowmegatron · 2025-10-23 original
Author claims negative ion generators lower serotonin and histamine, and that oceans and waterfalls naturally produce negative ions. Bullets and a Ray Peat quote say positive ions raise serotonin and negative ions reduce brain serotonin and histamine. The embedded lowmegatron post lists substances and practices said to lower or block serotonin.
Source summary and thread relationship - @lowmegatron · 2025-11-01 original
The post claims hypothyroidism causes low sperm count, low testosterone, low libido and high prolactin, and that correcting it doubles testosterone, increases sperm count, lowers prolactin and improves libido. It quotes a study excerpt on hypothyroid men treated with thyroxine. An embedded earlier post claims hypothyroidism activates the sympathetic nervous system and raises stress hormones and blood pressure, reversible with thyroid hormone.
Source summary and thread relationship - @lowmegatron · 2025-11-05 original
The author claims pregnenolone increases deep sleep, which is essential for testosterone production in men. The post quotes study excerpts on 1 mg oral pregnenolone increasing slow wave sleep and on lower morning salivary testosterone when deep sleep was suppressed. The embedded post quotes a paper reporting decreased stage 3 and 4 sleep in hypothyroidism, possibly increased by desiccated thyroid.
Source summary and thread relationship - @lowmegatron · 2025-11-06 original
The post shares a Ray Peat quotation on minimizing the harmful effects of serotonin through diet, light and specific agents. The quoted lowmegatron post lists compounds and practices said to lower or block serotonin.
Source summary and thread relationship - @lowmegatron · 2025-11-09 original
The author lists claimed effects of high prolactin, its claimed causes (stress, serotonin, hypothyroidism, low zinc, seed oils, etc.) and things he says may lower it (zinc, DHT, coffee, aspirin, bright light, progesterone, thyroid optimization, etc.).
Source summary and thread relationship - @lowmegatron · 2025-11-10 original
The post quotes Ray Peat saying serotonin reuptake inhibitor antidepressants increase prolactin and were found to cause osteoporosis after prolonged use. The embedded lowmegatron post lists symptoms attributed to high prolactin, causes of high prolactin, and factors said to lower it.
Source summary and thread relationship - @lowmegatron · 2025-11-11 original
The post asks whether anyone uses cyproheptadine for insomnia and quotes Ray Peat saying it works extremely well at a much smaller dose than usually recommended (1 mg or less), while 4 mg sometimes makes people goofy the next day. The embedded lowmegatron post claims 1 mg pregnenolone increased slow-wave sleep and that deep sleep supports testosterone.
Source summary and thread relationship - @lowmegatron · 2025-11-11 original
The post claims aspirin can boost dopamine and may help in Parkinson's. It says aspirin increases tyrosine hydroxylase, which is needed to make dopamine, and that this was shown in lab-grown brain cells and live mice. The embedded lowmegatron post lists substances and practices claimed to lower or block serotonin.
Source summary and thread relationship - @lowmegatron · 2025-11-12 original
The author claims polyunsaturated fats such as linoleic and arachidonic acid interfere with vitamin D binding to DBP, while saturated fats do not. The embedded lowmegatron post lists strategies to protect against seed oils and polyunsaturated fats, including supplements, foods and fats to eat or avoid.
Source summary and thread relationship - @lowmegatron · 2025-11-17 original
The author quotes Ray Peat saying that with insufficient cholesterol the high postpartum progesterone is unlikely to be maintained, and that pro-inflammatory effects of serotonin and estrogen then predominate, causing depression, joint pain, anxiety and brain edema. The author adds that postpartum depression drugs (brexanolone, zuranolone) relate to allopregnanolone, a progesterone metabolite. They also lay out the cholesterol-to-allopregnanolone pathway and note its dependence on T3 and vitamin A. They cite a postpartum cholesterol and mood study (PMID 8845727). The embedded lowmegatron post quotes a thyroid study on T3, TSH and depression (PMID 9971866).
Source summary and thread relationship - @lowmegatron · 2025-11-18 original
The post states that in-utero acetaminophen exposure feminizes males. It supports this with quoted text from a mouse study (PMID 28559473) reporting fewer neurons in the sexually dimorphic nucleus of the preoptic area and altered sexual and territorial behavior in exposed male offspring. An embedded lowmegatron post claims finasteride in rats affected sexual behavior.
Source summary and thread relationship - @lowmegatron · 2025-11-18 original
The post quotes Ray Peat as preferring Coca-Cola to Pepsi, because from mineral analyses he had seen Coke would have more botanical extracts. It also shows a quoted post from lowmegatron citing a mouse study, in which Coca-Cola or Pepsi was associated with higher testis mass, serum testosterone and androgen receptor mRNA expression.
Source summary and thread relationship - @lowmegatron · 2025-11-19 original
The author says that men on a long-term low-PUFA diet should master de-escalation. This is a reply-style remark to a quoted post, which jokes that very large testicles raise the risk of contusions during a fight. The exchange is largely humorous or social, and no mechanism or evidence is given.
Source summary and thread relationship - @lowmegatron · 2025-11-21 original
Author says cocaine amplifies endotoxin effects while magnesium protects. Slightly elevated endotoxin is said to cause depression, T2 diabetes, low testosterone, infertility and cardiovascular disease, while very high levels can be lethal. A quoted rat study reports worse survival with magnesium deficiency. The embedded post links endotoxin to diabetes and fatty liver, quoting Ray Peat and human studies.
Source summary and thread relationship - @lowmegatron · 2025-11-21 original
The post author says endotoxin raises cortisol and that chronically elevated cortisol can cause low testosterone, weight gain, insulin resistance, type 2 diabetes and depression. They quote a human endotoxin-administration study reporting dose-related rises in inflammatory markers, cortisol and norepinephrine. The embedded quoted post from lowmegatron says blocking the glucocorticoid receptor lowers glucose and insulin in obese diabetic mice. It also lists many things it says help lower cortisol.
Source summary and thread relationship - @lowmegatron · 2025-11-21 original
The post author says vitamin K protects against the testosterone reduction caused by bacterial endotoxin. They quote a rat study in which rats on a vitamin K-free diet had lower plasma testosterone after endotoxin than controls. The embedded quoted post from lowmegatron says endotoxin causes low testosterone and infertility in men.
Source summary and thread relationship - @lowmegatron · 2025-11-23 original
Ray Peat, quoted by the author, suggests pregnenolone avoids the risk of DHEA converting to estrogen when thyroid function is low. He says a small amount of Armour thyroid could quickly lower cholesterol and probably help testosterone, and recommends shellfish, low-fat fish, eggs, liver, cooked potatoes with butter or cream, fruit and cooked greens for nutrients.
Source summary and thread relationship - @lowmegatron · 2025-11-23 original
The post says thyroid hormone (T4) replacement roughly doubled free and total testosterone and halved prolactin in hypothyroid men. It quotes the study's conclusion that primary hypothyroidism can cause reversible hypogonadotrophic hypogonadism. The author adds that the men were still far from optimal and that more progress was possible. The embedded quoted post (lowmegatron) gives a Ray Peat quote on low testosterone and high cortisol.
Source summary and thread relationship - @lowmegatron · 2025-11-23 original
The post says hypothyroidism decreases testosterone and testicular weight. It quotes a rat study of experimentally induced hypothyroidism, which reported lower testosterone and body and testes weight with no change in LH and FSH. The embedded quoted post is the earlier human T4 replacement study post by lowmegatron.
Source summary and thread relationship - @lowmegatron · 2025-11-23 original
The post says subclinical hypothyroidism causes low testosterone and erectile dysfunction. It reports that men with TSH 4.5-10 and normal T4 had lower testosterone, higher prolactin and weaker sperm, and that two thirds reported ED. The post claims TSH above 2.0 should be a red flag but is usually ignored. The embedded quoted post is the earlier rat hypothyroidism post.
Source summary and thread relationship - @lowmegatron · 2025-11-23 original
The post shares a Ray Peat quote saying topical testosterone is safe if diet and thyroid function are good, but that pregnenolone and then DHEA should be tried first to normalize testosterone production. The embedded quoted post is the earlier subclinical hypothyroidism post by lowmegatron.
Source summary and thread relationship - @lowmegatron · 2025-11-25 original
The author asks 'Phthlate gut?' and lists health harms attributed to phthalates, including reduced testosterone, reproductive, neurodevelopmental, metabolic, respiratory and thyroid effects. The post quotes a human correlation finding on abdominal obesity and insulin resistance and a mouse study reporting weight gain and metabolic changes. The embedded post by lowmegatron claims phthalates are detoxed by glucuronidation and lists factors said to help or hinder it.
Source summary and thread relationship - @lowmegatron · 2025-11-27 original
The author cites a study excerpt claiming high prolactin reduces the conversion of testosterone to DHT by 5-alpha-reductase in men. He adds that hypothyroidism doubles prolactin in men. The quoted context says thyroid hormone doubled testosterone and halved prolactin in hypothyroid men treated with T4.
Source summary and thread relationship - @lowmegatron · 2025-11-27 original
The post asks whether supplements can safely raise serum androgens in men if diet is good, and answers with a Ray Peat quote. Peat says pregnenolone has favorable effects. He also says thyroid or aspirin can improve the androgen-to-cortisol/estrogen ratio, and that low-dose DHEA can help if thyroid function is good. An embedded post by lowmegatron links subclinical hypothyroidism to low testosterone and ED in men.
Source summary and thread relationship - @lowmegatron · 2025-11-28 original
The author asserts that polyester underwear makes men infertile and shrinks the testicles. The post quotes a paper proposing a theory that an electrostatic field from polyester underpants disturbs testicular function, with diminished spermatogenesis in dogs. The embedded earlier post reports an association between higher omega-6 intake and smaller testicular volume in young Spanish men.
Source summary and thread relationship - @lowmegatron · 2025-12-01 original
The author says endotoxin lowers testosterone by impairing cellular energy production, quoting mouse and Leydig cell mitochondria research. The embedded lowmegatron post says endotoxin raises cortisol and cites human study data.
Source summary and thread relationship - @lowmegatron · 2025-12-02 own thread
lowmegatron quotes study conclusions suggesting altered regulation of prolactin secretion in cluster headache periods and symptom-free intervals, and that sleep, estradiol, testosterone, medication, pain, and serotonergic and dopaminergic mechanisms are discussed.
Source summary and thread relationship - @lowmegatron · 2025-12-02 original
The author introduces a thread on lowering excess prolactin and lists conditions and symptoms attributed to high prolactin. The lowering methods themselves are not in the retrieved text.
Source summary and thread relationship - @lowmegatron · 2025-12-02 own thread
lowmegatron advises optimizing thyroid to lower prolactin. He claims low thyroid hormones increase TRH stimulation of prolactin and that subclinical hypothyroidism is associated with elevated prolactin. He quotes a study in which hypothyroid cases had lower total testosterone and free T4 and higher prolactin.
Source summary and thread relationship - @lowmegatron · 2025-12-02 own thread
lowmegatron reports that a Tribulus terrestris extract lowered prolactin by over 50% in four weeks in infertile men. The study used Androsten (250 mg dried extract per capsule).
Source summary and thread relationship - @lowmegatron · 2025-12-03 original
Author claims hypothyroidism lowers testosterone, shrinks testicles and causes male infertility. Author backs this with quotes from Ray Peat and Broda Otto Barnes, rodent experiments (PTU-induced hypothyroidism, rdw rats with thyroxine treatment), a Nigerian cross-sectional study of infertile men, and a prospective controlled study on sperm morphology. The embedded quoted post claims TSH/T4 and even T3 tests are limited and that T3-activating cells matter.
Source summary and thread relationship - @lowmegatron · 2025-12-05 original
The author claims zinc is overlooked in thyroid status and may independently contribute to hypothyroid hair loss. He cites studies on zinc preventing exercise-related drops in thyroid hormones, zinc opposing melatonin's thyroid suppression, and zinc raising T3. He speculates zinc helps T4-to-T3 conversion.
Source summary and thread relationship - @lowmegatron · 2025-12-20 original
The author argues that parathyroid hormone (PTH) and prolactin lower male libido and fertility. Quoted study excerpts describe PTH raising prolactin, cabergoline and metergoline lowering prolactin with improved sexual function or spermatogenesis, and higher prolactin in older men with low libido. The author also lists factors that raise PTH. The embedded post by lowmegatron says adequate calcium may help keep lead out of blood, especially in pregnancy.
Source summary and thread relationship - @lowmegatron · 2026-01-05 original
The post quotes Ray Peat linking lower parathyroid hormone (via calcium and vitamin D) to reduced obesity and related problems. It adds quoted PMID excerpts associating depression with low vitamin D and high PTH and describing neuropsychiatric symptoms in primary hyperparathyroidism. It lists factors that can raise PTH. An embedded lowmegatron post links PTH and prolactin to men's libido and fertility.
Source summary and thread relationship - @lowmegatron · 2026-01-08 original
States hypothyroidism can cause low testosterone in men via prolactin elevation and free testosterone drop, reversible by optimizing TSH and T3.
Source summary and thread relationship - @lowmegatron · 2026-01-10 own thread
lowmegatron claims vitamin C lowers stress-induced cortisol release, quoting studies on ascorbic acid inhibiting cortisol secretion after ACTH and on vitamin C in women with functional hypercortisolemia or elevated DHEA-S. He says he prefers vitamin C from foods such as fruit, juice and acerola powder.
Source summary and thread relationship - @lowmegatron · 2026-01-10 own thread
lowmegatron says DHEA may also lower 11β-HSD1 and local cortisol generation. The post quotes a study (PMID 15613680) on DHEA, blood glucose and insulin sensitivity in obese rodents and humans. The author adds an opinion that low doses (no more than 5 mg, 3 times a day) are probably best because DHEA can otherwise increase estrogen.
Source summary and thread relationship - @lowmegatron · 2026-01-10 own thread
lowmegatron claims creatine reduces stress-induced increases in cortisol. The quoted study says more than 5 days of creatine combined with resistance exercise was sufficient to increase testosterone and decrease cortisol concentrations.
Source summary and thread relationship - @lowmegatron · 2026-01-12 original
DHEA improves insulin sensitivity and reduces abdominal fat through decreased local cortisol production via 11β-HSD1 inhibition; coffee, vitamin D, and aspirin share this mechanism.
Source summary and thread relationship - @lowmegatron · 2026-01-12 own thread
lowmegatron quotes a randomized trial in which elderly women and men took 50 mg/day DHEA or placebo for 6 months. The quote says DHEA reduced abdominal fat and improved the insulin sensitivity index.
Source summary and thread relationship - @lowmegatron · 2026-01-12 own thread
lowmegatron quotes a paper reporting that in 3T3-L1 adipocytes DHEA downregulated 11β-HSD1 and reduced its oxoreductase activity, comparably to rosiglitazone but not additively. The authors propose that some of DHEA's anti-diabetic effects may come from inhibiting local glucocorticoid amplification in adipose tissue.
Source summary and thread relationship - @lowmegatron · 2026-01-12 own thread
lowmegatron quotes a paper stating that 50 mg DHEA replacement improved glucose tolerance in participants who initially had abnormal glucose tolerance.
Source summary and thread relationship - @lowmegatron · 2026-01-12 own thread
lowmegatron quotes a rat study in which animals fed a high-fat diet plus 0.3% DHEA were largely protected against increased visceral fat. The quote concludes DHEA protects against visceral fat accumulation and muscle insulin resistance in these rats.
Source summary and thread relationship - @lowmegatron · 2026-01-12 own thread
lowmegatron states that high doses of DHEA can be estrogenic. He says he thinks 5 mg or less up to 3 times daily topically is safer and points to old Haidut discussions on the raypeatforum for details.
Source summary and thread relationship - @lowmegatron · 2026-01-12 original
The author claims low thyroid hormone can lower androgens, neurosteroids and other steroids derived from pregnenolone, such as DHT, DHEA, testosterone, progesterone and allopregnanolone. He says T3 regulates StAR, which shuttles cholesterol into mitochondria. The quoted context claims hypothyroidism can cause low testosterone with raised prolactin.
Source summary and thread relationship - @lowmegatron · 2026-01-23 original
Endotoxin from intestinal bacteria suppresses thyroid hormones and testosterone production through multiple mechanisms, with supporting evidence from human and animal studies.
Source summary and thread relationship - @lowmegatron · 2026-01-23 original
Polyunsaturated fat-driven lipid peroxidation damages testicular function and fertility; protective measures include vitamin E, coconut oil, and antioxidants from citrus.
Source summary and thread relationship - @lowmegatron · 2026-01-27 original
Knowledge claim on vitamin A's role in neurosteroid production for mood and mental health; Ray Peat quotation on vitamin A activation of steroid-forming enzymes; connection to allopregnanolone pathway.
Source summary and thread relationship - @lowmegatron · 2026-01-28 original
Thyroid hormone doubles testosterone in hypothyroid men, with both free and total testosterone doubling, prolactin dropping significantly, while men remained hypothyroid (TSH 5.3) on average. Study link provided but not accessible in retrieved text.
Source summary and thread relationship - @lowmegatron · 2026-01-28 original
Ray Peat quoted on T3 effects on aromatase inhibition and testosterone efficacy in men. Claims T3 lowers aromatase; elevated aromatase from stress lowers testosterone and increases estrogen. Discusses how T3, aspirin, pregnenolone, or progesterone inhibit aromatase and improve testosterone effectiveness.
Source summary and thread relationship - @lowmegatron · 2026-02-01 original
Bacterial endotoxin lowers testosterone through direct testicular effects (the 'GELDING effect'); vitamin K protects against endotoxin-induced testosterone reduction.
Source summary and thread relationship - @lowmegatron · 2026-02-04 original
Vitamin C 1g/day reduces cortisol by 20-40% and DHEA-S by 30-40% in response to chronic stress; cited study supports use in female patients with elevated cortisol or DHEA-S.
Source summary and thread relationship - @lowmegatron · 2026-02-05 original
Ray Peat quotation on stress hormones (elevated cortisol, decreased DHEA/progesterone/testosterone) driving inflammation, degeneration and depression as a protective shutdown response. Embedded post on hypothyroidism-cortisol relationship, TSH thresholds, T3 effects on cortisol metabolism enzymes, sympathetic activation and blood pressure.
Source summary and thread relationship - @lowmegatron · 2026-02-12 original
The author explains 5α-reductase-2 deficiency, in which testosterone is made but conversion to DHT is impaired, leading to atypical genital development and sparse facial and body hair. He says it is usually genetic but can also be caused by hypothyroidism. He cites a report of children with severe untreated hypothyroidism whose urine steroid patterns mimicked the deficiency and reversed completely on thyroid replacement. The quoted conclusion urges excluding hypothyroidism in DSD workups.
Source summary and thread relationship - @lowmegatron · 2026-02-15 original
T3, aspirin, and pregnenolone or progesterone inhibit aromatase and enhance testosterone effectiveness; mechanism involves reducing estrogen excess from stress-induced aromatase elevation.
Source summary and thread relationship - @lowmegatron · 2026-02-16 original
Ray Peat passage discussing polyunsaturated fat toxicity in high-fat diet using Eskimo diet example; explains mechanism of thyroid hormone promotion in traditional Eskimo diet through consumption of organ meats (thyroid gland, brain) containing cholesterol and steroid hormone precursors; contrasts with negative effects of polyunsaturated fat on thyroid function.
Source summary and thread relationship - @lowmegatron · 2026-02-19 original
Author claims hypothyroid men have lower libido, larger prostates, lower testosterone, and lower sexual satisfaction. Cites study finding prevalence of hypogonadism 13.8% in hypothyroid patients vs. 6.5% in normal thyroid function group. Includes embedded quote on how hypothyroidism causes elevated prolactin and dropped free testosterone, correctable by restoring thyroid levels.
Source summary and thread relationship - @lowmegatron · 2026-02-26 original
Endotoxin may cause low testosterone in obese men through inflammation; men with higher blood endotoxin levels have lower testosterone; endotoxin injection into healthy men lowers testosterone; adiposity correlates with endotoxin and inflammation and inversely with testosterone.
Source summary and thread relationship - @lowmegatron · 2026-03-03 original
Zinc protects against stress-induced decrements in thyroid hormones and testosterone and improves weight loss, inflammation, and insulin sensitivity in obese people in caloric deficit. Two studies quoted on zinc supplementation effects. Embedded quoted post details high-dose zinc effects on T3, reverse T3, and thyroid hormone conversion in zinc-deficient people.
Source summary and thread relationship - @lowmegatron · 2026-03-06 original
Ray Peat quotation describes high metabolic rate in young people converting cholesterol into pregnenolone, DHEA, and progesterone to maintain low blood cholesterol; age-related decline in metabolic rate increases cholesterol as a regulatory process supporting synthesis of protective neurosteroids. Embedded post cites clinical evidence that thyroid is the only thing safely lowering cholesterol and that thyroid dysfunction impacts lipid profiles.
Source summary and thread relationship - @lowmegatron · 2026-03-09 original
Author explains low thyroid hormone reduces energy to non-essential functions including testosterone and fertility in men; compares T4 (levothyroxine) versus T3 (liothyronine) therapy; notes downstream conversion and uptake issues. Quotes three studies on hypothyroidism, testosterone, sexual function, and spermatogenesis.
Source summary and thread relationship - @lowmegatron · 2026-03-12 original
Testosterone supplementation reduces thyroid antibodies (TPOAb and TgAb) in men with low testosterone and Hashimoto's disease. Selenium alone also reduces antibodies but testosterone produces greater reduction.
Source summary and thread relationship - @lowmegatron · 2026-03-14 original
Author lists interventions reported to lower thyroid antibodies (TPOAb, TGAb) with effect sizes, including near-infrared light, vitamin D, selenium, vitamin C, testosterone in deficient men, and levothyroxine; notes LDN, gluten removal, and dairy removal help a minority.
Source summary and thread relationship - @lowmegatron · 2026-03-16 original
Author quotes Ray Peat on thyroid hormone's role in regulating adrenaline, serotonin, and estrogen; discusses methylene blue as electron-carrier substitute for thyroid hormone in treating depression and dementia; embeds lowmegatron post linking hypothyroidism to dementia risk, especially in patients on thyroid medication.
Source summary and thread relationship - @lowmegatron · 2026-03-25 own thread
The post text is only links. Its quoted post by lowmegatron lists claimed ways to address endotoxin, including cascara sagrada, minocycline, aspirin, cocoa, coffee, DHEA, ginger, glycine, sleep, naringenin, orange juice, pregnenolone, progesterone, probiotics, sugar, taurine, several vitamins, mushrooms and zinc, and notes PUFA-rich high-fat diets may raise endotoxin.
Source summary and thread relationship - @lowmegatron · 2026-04-01 original
Boswellia resin and Boswellic acids (especially Acetyl-11-keto-ß-boswellic acid) have anti-inflammatory and anti-cancer properties through 5-LOX and COX inhibition, reducing polyunsaturated fat-derived inflammatory molecules. Relevant to cancer prevention, arthritis, Crohn's disease, asthma, and bronchitis.
Source summary and thread relationship - @lowmegatron · 2026-04-06 original
Ray Peat quotation on thyroid hormone and vitamin A roles in converting cholesterol to pregnenolone, steroid hormone synthesis, and compensatory cholesterol mechanisms during stress-induced thyroid suppression.
Source summary and thread relationship - @lowmegatron · 2026-04-09 original
Ray Peat advises against topical application of fat-soluble vitamins or steroid hormones to testicles, citing risk to gonadal lipid environment. Recommends arms or legs as alternative application sites for DHEA, pregnenolone, and progesterone.
Source summary and thread relationship - @lowmegatron · 2026-04-12 original
Brief dismissal of Ray Peat-attributed claims about body odor and hygiene, stating one should shower daily and use hygiene practices. Embedded quoted post contains detailed personal narrative about extreme hygiene experimentation.
Source summary and thread relationship - @lowmegatron · 2026-04-15 original
Bacterial endotoxin (LPS) lowers both TSH and thyroid hormones, creating misleading thyroid test results. Multiple dietary and supplemental compounds may reduce endotoxin burden or its effects.
Source summary and thread relationship - @lowmegatron · 2026-04-19 original
Thread introduction listing health effects of high prolactin including fatigue, anxiety, infertility, low libido, depression, weight gain, amenorrhea, osteoporosis, gynecomastia, prostate growth, vaginal dryness, sexual dysfunction, low LH/FSH, sleep disturbances, and migraines. Post is repost of @lowmegatron's original thread on lowering excess prolactin.
Source summary and thread relationship - @lowmegatron · 2026-04-20 original
Study of Spanish men found inverse relationship between omega-6 fatty acid intake and testicular volume. Quoted account raises hypothesis about vitamin E/PUFA ratio and infertility.
Source summary and thread relationship - @lowmegatron · 2026-04-22 original
lowmegatron claims that nearly 40% of Americans take drugs that can cause depression, which he calls a low estimate. He lists drug classes said to be identified in JAMA, including antidepressants, ethinyl estradiol, estradiol, finasteride, antihypertensives, sedatives, analgesics, acid reducers, anticonvulsants and corticosteroids.
Source summary and thread relationship - @lowmegatron · 2026-04-22 original
Calcium deficiency increases aromatase enzyme and estrogen in male rodents; vitamin K2 (MK-4) blocks elevated estrogen and bone loss; calcium plus training increases free testosterone 25% versus 4% for training alone; elevated aromatase and prolactin suppress testosterone.
Source summary and thread relationship - @lowmegatron · 2026-04-24 original
Lita Lee quote on pregnenolone as major anti-aging steroid; claims adequate thyroid converts LDL cholesterol to pregnenolone which opposes cortisol toxicity, prevents panic attacks, and converts to progesterone/DHEA as needed. States pregnenolone increases mental focus and prevents cognitive decline. Embedded Ray Peat quote on pregnenolone and progesterone's rapid water-retention effects via estrogen opposition.
Source summary and thread relationship - @lowmegatron · 2026-04-24 original
Reports 1990s animal research finding pregnenolone several hundred times more potent than tested memory enhancers, with mechanism via transcription facilitation. Cites human studies showing pregnenolone improves memory and pregnenolone augmentation improves attention/working memory in schizophrenia patients. Embedded post on thyroid hormone correlation with memory in depressed patients, showing levothyroxine treatment resolved multiple symptoms including failing memory.
Source summary and thread relationship - @lowmegatron · 2026-04-25 original
Ray Peat quote recounting personal experience with moles: avoided direct application due to cancerization risk; reports observed shrinking of moles within days when applying progesterone or DHEA (in vitamin E) 1 inch away, with steady shrinking over 7-10 days. Also describes increasing T3 thyroid hormone dosing to maintain normal daytime temperature and elevated resting pulse (95 bpm), and soaking in epsom salts/baking soda/salt baths for mole acceleration.
Source summary and thread relationship - @lowmegatron · 2026-04-25 original
Reports pregnenolone activates emotional regulation brain circuits, reducing negative-circuit activation linked to anxiety. Explains mechanism via conversion to allopregnanolone, noting allopregnanolone was prescribed for postpartum depression at ~40,000 USD (synthetic analog at 15,000+ USD), while pregnenolone costs dollars. Cites research using 400 mg oral pregnenolone dose. Attributes Ray Peat quote on thyroid hormone and vitamin A role in cholesterol-to-pregnenolone conversion. Recommends Balanced Body Mind (UK) and Raena (US) pregnenolone brands without disclosed affiliation.
Source summary and thread relationship - @lowmegatron · 2026-04-27 original
Higher progesterone levels in women and higher testosterone and progesterone in men predict lower stress response. Study measured ACTH and cortisol response to Trier Social Stress Test (TSST). Progesterone inhibits HPA axis reactivity in women; testosterone inhibits it in men. Women studied during follicular phase.
Source summary and thread relationship - @lowmegatron · 2026-04-28 original
Low testosterone twice as likely in hypothyroid men; thyroid supplementation doubles free/total testosterone and halves prolactin; sexual dysfunction reversible with thyroid correction.
Source summary and thread relationship - @lowmegatron · 2026-04-28 original
lowmegatron claims he can tell estrogen:progesterone and serotonin:DHT balance from text alone. The quoted post claims that fat distribution reflects hormones, and that claim belongs to the quoted author, not to lowmegatron.
Source summary and thread relationship - @lowmegatron · 2026-05-08 original
Author quotes Ray Peat on thyroid hormone T3 decline with aging and impact on steroid hormone production (pregnenolone and progesterone); presents human study showing pregnenolone reduces stress-induced alcohol cravings.
Source summary and thread relationship - @lowmegatron · 2026-05-14 original
Quoted Ray Peat anecdote: hangnails disappeared after getting progesterone on hands in lab accident, never returned; nested anecdote about mole changes with progesterone/DHEA and T3 dosing.
Source summary and thread relationship - @lowmegatron · 2026-05-21 original
PCOS is nearly 3 times more likely in autoimmune thyroid disease (primarily Hashimoto's). Women with PCOS are about 3 times as likely to have subclinical hypothyroidism, with odds increasing when TSH ≥4 mIU/L. Ray Peat is quoted that PCOS can be produced in animals by thyroidectomy due to impaired ovarian progesterone synthesis.
Source summary and thread relationship - @lowmegatron · 2026-05-22 original
DHEA increases 11β-HSD2 enzyme activity, which locally inactivates cortisol to cortisone at the tissue level, independent of blood cortisol levels. This reduces cortisol's receptor activation in tissues. Elevated tissue-level cortisol, even with normal blood levels, contributes to insulin resistance, visceral fat, dyslipidemia, hypertension, cardiovascular disease, neurodegeneration, depression, anxiety, sleep impairment, immune suppression, poor wound healing, osteoporosis, muscle wasting, hormone dysregulation, and skin deterioration. Optimal DHEA dosing is 3-5 mg, 1-3 times daily. Higher doses become estrogenic; topical application combined with pregnenolone maximizes anti-cortisol effects while minimizing estrogen conversion. Coffee, aspirin, and vitamin D reduce activity of the related 11β-HSD1 enzyme.
Source summary and thread relationship - @lowmegatron · 2026-05-22 original
Sharing a Ray Peat quotation on thyroid hormone (T3) converting cholesterol into pregnenolone, progesterone, and DHEA, with embedded secondary post discussing the same mechanism and additional claims about pregnenolone anti-aging effects.
Source summary and thread relationship - @lowmegatron · 2026-05-25 original
Progesterone stabilizes mast cells by inhibiting histamine secretion, which may explain reduced inflammatory symptoms during pregnancy. Quotation cites rat peritoneal mast cell study showing progesterone inhibits histamine secretion triggered immunologically or by substance P.
Source summary and thread relationship - @lowmegatron · 2026-05-26 original
Hypothyroidism is an overlooked cause of hiatal hernia. Reduced thyroid hormone and elevated stress hormones (cortisol in relation to testosterone and DHEA) weaken connective tissues. Research shows hypothyroidism is an early sign of hiatal hernia and gastroesophageal reflux disease (GERD), associated with gastrointestinal motor-evacuatory disturbances rather than acid exposure. Severe hypothyroidism causes esophageal peristalsis disturbances, myxedema-related oropharyngeal dysphagia, and hiatal hernia.
Source summary and thread relationship - @lowmegatron · 2026-06-01 original
Practical tips for lowering prolactin and serotonin through thyroid optimization, nutrient status, dietary fat composition, light exposure, supplements, and specific compounds; includes embedded quote on cyproheptadine mechanism for SSRI sexual dysfunction.
Source summary and thread relationship - @lowmegatron · 2026-06-01 original
Explanation of reverse T3 elevation as stress marker; cortisol and other counterregulatory hormones shift T4 conversion toward rT3 while raising free fatty acids that impair thyroid function; lists interventions to lower cortisol and suggests T3:T4 ratio optimization in levothyroxine users.
Source summary and thread relationship - @lowmegatron · 2026-06-01 original
Evidence-based review of cortisol's role in glucose dysregulation in diabetes; cites clinical and animal studies showing cortisol effects on blood sugar, insulin resistance, and reversal with glucocorticoid receptor blockade; discusses mechanisms and dietary strategies affecting cortisol.
Source summary and thread relationship - @lowmegatron · 2026-06-02 original
Explanation of two-enzyme system (11β-HSD1 and 11β-HSD2) controlling tissue cortisol activation and inactivation; notes thyroid hormone T3 influences balance toward inactivation; contrasts pharmaceutical research with clinician ignorance of T3 assessment; lists multiple interventions affecting enzyme balance.
Source summary and thread relationship - @1immortals1 · 2026-06-09 original
Personal account of raising testosterone from 280 ng/dL (at age 26, below reference range for healthy males starting at 600) to 687 ng/dL in 90 days through four lifestyle changes: eliminating seed oils, 30 minutes morning sunlight exposure, sleeping in pitch-black room at consistent time, and 3 minutes cold water at end of showers. No supplements costing more than $15 used. Doctor initially disbelieved and retested results.
Source summary and thread relationship - @1immortals1 · 2026-06-16 original
Chronic mouth breathing impairs facial development, sleep quality, focus and testosterone by bypassing nasal filtration and nitric oxide production. Nasal breathing activates parasympathetic nervous system. Mouth taping at night is presented as zero-cost intervention.
Source summary and thread relationship - @1immortals1 · 2026-06-17 original
Tongkat ali is the only natural supplement with clinical evidence of raising testosterone in healthy men; author recommends 200-400mg daily of standardized extract and criticizes the supplement industry's profit motives.
Source summary and thread relationship - @1immortals1 · 2026-06-19 original
Red light and near-infrared light (630-850nm) penetrates skin and increases ATP production via cytochrome c oxidase in mitochondria. Lists multiple claimed health benefits including wound healing, pain reduction, testosterone increase, skin improvements, muscle recovery, and thyroid function. Contrasts low-cost bulb options with expensive commercial panels.
Source summary and thread relationship - @1immortals1 · 2026-06-20 original
Shilajit, a mineral-dense resin from Himalayan rocks formed from compressed plant matter over centuries, contains 85+ minerals in bioavailable form and has been used in Ayurvedic medicine for 3,000 years. Contains fulvic acid for nutrient transport, increases mitochondrial CoQ10, shown to increase testosterone 23.5% in clinical study, improves sperm count and motility, reduces altitude fatigue, and enhances other supplement absorption.
Source summary and thread relationship - @lowmegatron · 2026-06-22 original
lowmegatron says accidental exposure to owners' transdermal estradiol gel caused hair loss in dogs. The quoted case reports describe the alopecia resolving after the exposure stopped.
Source summary and thread relationship - @1immortals1 · 2026-06-22 original
Ashwagandha is an adaptogen that modulates cortisol regulation and stress resilience. Specific clinical benefits include cortisol reduction, improved VO2 max, testosterone increase, anxiety reduction, sleep quality improvement, and cognitive enhancement. Recommends 600mg KSM-66 extract daily taken in evening, paired with magnesium threonate.
Source summary and thread relationship - @1immortals1 · 2026-06-23 original
Vitamin D deficiency (42% of American adults, >70% in northern latitudes in winter) is a hormone precursor regulating >1000 genes. Deficiency correlates with depression, 2x all-cause mortality risk, reduced testosterone, impaired immune function, poor calcium absorption, and reduced insulin sensitivity. Standard dosing inadequate; 5,000-10,000 IU daily for 8-12 weeks recommended for deficiency, then 4,000-5,000 IU maintenance. Take with fat and pair with K2.
Source summary and thread relationship - @1immortals1 · 2026-06-25 original
Boron supplementation at 10mg daily for 7 days is described as increasing free testosterone by 28% and decreasing estradiol by 39%, with additional improvements in SHBG, inflammatory markers, and vitamin D; dietary sources and supplementation recommendations provided.
Source summary and thread relationship - @lowmegatron · 2026-06-25 original
lowmegatron quotes Ray Peat on graying hair. Peat says he has seen DHEA correct it quickly, that melanin-producing enzymes need copper, and that shellfish is a good source of copper with less iron. The quote also recommends low DHEA doses and warns that excess DHEA may convert to estrogen or testosterone in people deficient in progesterone, pregnenolone or thyroid.
Source summary and thread relationship - @lowmegatron · 2026-06-26 original
Testosterone replacement therapy lowers thyroid antibodies (TPOAb and TgAb) and raises thyroid secretory capacity in men with low testosterone and Hashimoto's thyroiditis. TPOAb decreased 31%, TgAb decreased 23%. This is the first study demonstrating a protective effect of exogenous testosterone on thyroid autoimmunity.
Source summary and thread relationship - @1immortals1 · 2026-06-26 original
Vitamin K2 is essential when supplementing vitamin D and calcium because without it, calcium deposits in arteries and soft tissues instead of bones and teeth. K2 activates osteocalcin and matrix GLA protein which direct calcium to proper locations. High K2 intake associated with reduced cardiovascular mortality and arterial calcification; improves bone density and may enhance insulin sensitivity and testosterone.
Source summary and thread relationship - @1immortals1 · 2026-06-27 original
Substantive explanation of rhodiola rosea as Soviet-era adaptogen used by Olympic athletes and cosmonauts; details purported mechanisms (effort reduction, endurance, cortisol/testosterone ratio, cognition, burnout reduction, antidepressant effects) with dosing recommendation.
Source summary and thread relationship - @jamesbondwisdom · 2026-06-29 original
jamesbondwisdom claims that hair loss is follicle miniaturization, not death. In his account, DHT binds androgen receptors and gradually shrinks susceptible follicles, which stay alive and can be recovered while vellus hairs are visible. He says DHT-blocking or follicle-stimulating treatments can reverse this, and that the transplant industry benefits from people thinking their hair is dead.
Source summary and thread relationship - @lowmegatron · 2026-06-29 original
lowmegatron says lavender and tea tree oils may cause gynecomastia. He quotes a report of three prepubertal boys whose breast enlargement coincided with topical products containing these oils and resolved after stopping. The quoted text also describes in vitro weak estrogenic and antiandrogenic activity, and notes that the effect on girls and women is unknown.
Source summary and thread relationship - @lowmegatron · 2026-06-29 original
Author presents Ray Peat quotes and citations on estrogen's adverse cardiovascular effects in men, including discussion of the Coronary Drug Project trial and elevated serum estradiol in men with heart disease.
Source summary and thread relationship - @jamesbondwisdom · 2026-06-29 original
jamesbondwisdom argues that finasteride blocks 5-alpha reductase and reduces DHT, and regrows hair. He warns of systemic effects on libido, erectile function and mood, cites persistent post-finasteride syndrome, and claims company-funded studies report lower side-effect rates than independent surveys. He suggests topical options and saw palmetto as less effective but local alternatives.
Source summary and thread relationship - @lowmegatron · 2026-06-29 original
Progesterone and testosterone protect against histamine while estrogen increases histamine formation and actions. Post includes Ray Peat quote and research on mast cell regulation. Embedded quote from lowmegatron describes personal PEA use for suspected histamine symptoms and reviews PEA evidence across multiple conditions.
Source summary and thread relationship - @1immortals1 · 2026-06-30 original
Ashwagandha with KSM66 extract reduces cortisol by up to 30% in 60 days at 600 mg daily. Multiple effects documented: improved sleep quality, increased testosterone in men, improved VO2 max, reduced stress and anxiety. Author emphasizes biochemical intervention before meditation.
Source summary and thread relationship - @1immortals1 · 2026-07-01 original
Author explains vitamin D as a hormone precursor, cites prevalence of deficiency (42% of American adults), describes mechanisms of vitamin D regulation across multiple body systems, and provides supplementation recommendations (4000-5000 IU daily, D3 form, optimal 40-60 ng/mL).
Source summary and thread relationship - @jamesbondwisdom · 2026-07-02 original
jamesbondwisdom claims that a study of 76 men found 400 mg daily pumpkin seed oil raised hair count by 40% versus 10% for placebo over 24 weeks. He attributes this to 5-alpha reductase inhibition and presents it as a cheap alternative to finasteride.
Source summary and thread relationship - @jamesbondwisdom · 2026-07-03 original
jamesbondwisdom retweets his own truncated post claiming that a study showed pumpkin seed oil increased hair count by 40% in 24 weeks. The rest is cut off.
Source summary and thread relationship - @lowmegatron · 2026-07-03 original
lowmegatron claims vitamin K2 can improve insulin sensitivity. He cites PCOS women taking 90 µg MK-7 for 8 weeks who had lower HOMA-IR, and men taking 30 mg MK-4 for 4 weeks who had better insulin sensitivity, possibly via carboxylated osteocalcin. The quoted parent discusses hypothyroidism and insulin resistance.
Source summary and thread relationship - @1immortals1 · 2026-07-05 original
Author explains zinc's role in testosterone production and male health, discusses prevalence of deficiency due to modern diet and lifestyle factors, distinguishes bioavailable zinc forms, recommends dosing and duration, and warns against copper depletion from excessive intake.
Source summary and thread relationship - @lowmegatron · 2026-07-05 own thread
lowmegatron quotes a passage claiming that natural steroids derived from pregnenolone, progesterone or DHEA help with water retention, edema and heart failure. The quote says this is because they antagonize aldosterone, which it claims causes inflammation and water retention.
Source summary and thread relationship - @1immortals1 · 2026-07-06 original
Vitamin D as a secosteroid hormone regulating 1,000+ genes; claimed deficiency in 80% of global population; linked to low energy, brain fog, respiratory infection risk, testosterone, serotonin, all-cause mortality, calcium absorption, systemic inflammation; recommendation of 4,000-5,000 IU daily with K2.
Source summary and thread relationship - @1immortals1 · 2026-07-07 original
Ashwagandha as stress hormone regulator; claims 30% cortisol reduction in 60 days via 600mg KSM-66 extract daily; effects on testosterone, VO2 max, anxiety, sleep, memory; mechanism via cortisol-hippocampus pathway; contrasts with pharmaceutical alternatives (SSRIs, sleep aids).
Source summary and thread relationship - @lowmegatron · 2026-07-08 original
Dose-response meta-analysis of coffee consumption and type 2 diabetes risk: 8% reduction with 1 cup daily, increasing to 33% reduction at 6 cups daily. Both caffeinated and decaffeinated coffee associated with risk reduction. Embedded post by lowmegatron lists antidepressant mechanisms: dopamine boost, cortisol reduction, inflammation decrease, testosterone increase, gut barrier strengthening, endotoxin reduction, prolactin reduction, energy increase.
Source summary and thread relationship - @jamesbondwisdom · 2026-07-08 original
The author claims saw palmetto inhibits both 5-alpha reductase types, reduces serum DHT 30-40%, and gives comparable results to finasteride without sexual side effects. He recommends 320mg standardized extract daily and says dermatologists ignore it because it is unpatentable.
Source summary and thread relationship - @1immortals1 · 2026-07-08 original
Author promotes tongkat ali supplement as testosterone booster with specific clinical evidence. Claims it increases free testosterone 37% in 4 weeks via SHBG reduction without suppressing natural production. Provides mechanism, cites one human study, lists effects on cortisol, sperm quality, and lean mass. Recommends 200mg daily standardized extract (2% eurycomanone, LJ100 brand), cycling protocol.
Source summary and thread relationship - @1immortals1 · 2026-07-10 original
Author explains morning sunlight exposure (10 minutes within 30 minutes of waking) as natural regulation of circadian rhythm through the suprachiasmatic nucleus (SCN), controlling cortisol, melatonin, testosterone, growth hormone, and body temperature. Contrasts effectiveness against supplements and sleep industry products, emphasizing outdoor light intensity requirements.
Source summary and thread relationship - @1immortals1 · 2026-07-13 original
Boron supplementation increases free testosterone by 28% within 7 days and decreases free estradiol by 39% through SHBG reduction. Mechanism: boron reduces sex hormone binding globulin, freeing already-produced testosterone. Additional benefits: reduces inflammatory biomarkers, improves vitamin D metabolism, enhances magnesium absorption, supports bone density. Average diet provides 1-3 mg; studies used 6-10 mg daily at cost of $0.03-0.04/day.
Source summary and thread relationship - @1immortals1 · 2026-07-14 original
Shilajit is a Himalayan resinous substance containing fulvic acid and 85+ minerals in ionic form; claimed to increase testosterone 20-23.5%, CoQ10 27%, improve energy through enhanced ATP production, provide adaptogenic stress modulation, and improve nutrient bioavailability. Recommended purified resin form at $30-40/jar.
Source summary and thread relationship - @lowmegatron · 2026-07-15 original
lowmegatron presents a case report, cited as 'Reversible Hair Loss due to Levothyroxine Overdose', of an infant with congenital hypothyroidism who developed diffuse non-scarring hair loss 15-20 days after starting levothyroxine. Hair regrew after the dose was reduced. The author concludes that overdose may cause hair loss. The author also gives a best-guess reading of the FT3 and FT4 levels because the assay ranges are not stated.
Source summary and thread relationship - @lowmegatron · 2026-07-15 original
Ray Peat anecdote: two moles appeared and grew during summer beer consumption, then shrank and disappeared when beer stopped; attributed to estrogen content. Embedded Ray Peat quote on topical progesterone/DHEA and increased T3 causing mole shrinkage, and epsom salt baths.
Source summary and thread relationship - @jamesbondwisdom · 2026-07-20 original
jamesbondwisdom claims that saw palmetto 320mg daily blocks 5-alpha reductase and improved hair growth in 38% of patients in a 24-month study. He says finasteride reached 68% but had sexual side effects. He also claims it reduces DHT by about 32% and he gives dosing and costs.
Source summary and thread relationship - @1immortals1 · 2026-07-20 original
Tongkat ali herbal supplement has multiple human clinical trials showing simultaneous increases in testosterone (37% in 4 weeks), reduction in cortisol (16%), and improved body composition without diet/exercise changes. Mechanism attributed to HPG axis support via eurypeptides enhancing Leydig cell function. Contains dosing recommendation and price estimate.
Source summary and thread relationship - @lowmegatron · 2026-07-20 original
Pregnenolone topical and oral application for anti-aging effects with mixed results. Ray Peat describes dramatic symptom resolution from pregnenolone during 1983 health crisis with multiple conditions (arterial inflammation, dental abscesses, asthma, migraines, colitis). Notes many pregnenolone products contaminated with estrogenic impurities; recommends BodyBalancedMind (UK) and mentions Raena as trusted brands.
Source summary and thread relationship - @jamesbondwisdom · 2026-07-21 original
jamesbondwisdom claims stinging nettle root extract blocks DHT through three mechanisms (5-alpha-reductase inhibition, SHBG binding, and aromatase inhibition) and also reduces inflammation and oxidative damage. The post compares it with finasteride, saw palmetto and minoxidil and suggests 300-600mg daily of standardized root extract, not leaf.
Source summary and thread relationship - @1immortals1 · 2026-07-21 original
Knowledge comparison of KSM-66 ashwagandha extract versus generic ashwagandha, detailing study results on cortisol, testosterone, VO2 max, sleep, anxiety, and muscle gain; recommends 600mg daily at $15-20/month for KSM-66 versus $8/month generic alternative.
Source summary and thread relationship - @lowmegatron · 2026-07-23 original
Author shares post describing chronic hyperventilation reducing testicular size through CO2 retention loss, sympathetic tone increase, and pelvic floor tension; proposes addressing root causes via cellular respiration support and breathing technique.
Source summary and thread relationship - @1immortals1 · 2026-07-23 original
Vitamin D is a secosteroid hormone regulating over 1,000 genes; deficiency is associated with depression, low testosterone, immune dysfunction, and increased mortality; most people are deficient and treated symptomatically instead. Author recommends testing and supplementation with 4,000-5,000 IU daily with vitamin K2.
Source summary and thread relationship - @jamesbondwisdom · 2026-07-25 original
jamesbondwisdom claims 60% of men with hair loss have untested zinc deficiency, that zinc inhibits 5-alpha-reductase, and that coffee and phytates impair absorption. He advises testing serum zinc (above 80 mcg/dL for hair) and suggests 30mg daily of zinc picolinate or other well-absorbed forms.
Source summary and thread relationship - @jamesbondwisdom · 2026-07-29 original
jamesbondwisdom claims saw palmetto inhibits 5-alpha reductase like finasteride, reducing DHT by about 32% with essentially no sexual side effects. He cites improved hair quality in 60% of participants and says it can be stacked with pumpkin seed oil. He recommends 320mg daily and says it is unpromoted because it yields no pharmaceutical revenue.
Source summary and thread relationship - @jamesbondwisdom · 2026-07-30 original
jamesbondwisdom claims 400mg/day pumpkin seed oil raised hair count 40% at 24 weeks versus 10% for placebo in a randomized double-blind trial. He attributes it to phytosterols inhibiting 5-alpha reductase, claims zero sexual side effects, and gives a dosing and stacking protocol.
Source summary and thread relationship - @1immortals1 · 2026-07-30 original
42% of American adults and >70% of northern latitude residents in winter are vitamin D deficient. Vitamin D is hormone precursor regulating >1,000 genes affecting immunity, mood, testosterone, bone density. Deficiency associated with 2× all-cause mortality risk. Typical physician dose (1,000 IU) is maintenance only; deficiency below 30 ng/mL requires 5,000–10,000 IU daily for 8–12 weeks, then 4,000–5,000 IU maintenance. Vitamin K2 (MK-7, 100–200 mcg) directs calcium to bone; D without K2 risks cardiovascular calcification.
Source summary and thread relationship - @lowmegatron · 2026-07-30 original
Author lists interventions shown to lower thyroid antibodies in autoimmune thyroiditis, citing multiple peer-reviewed studies. Cautions that selenium and vitamin D optimization requires measurement, not blind supplementation.
Source summary and thread relationship - @1immortals1 · 2026-07-31 original
Author explains ashwagandha's cortisol-regulating and testosterone-boosting effects, emphasizing that clinical benefits require KSM-66 extract at 5% withanolides, not generic ashwagandha powder, and recommending 600 mg daily with cycling.
Source summary and thread relationship - @1immortals1 · 2026-08-02 original
Author claims tongkat ali is the only natural supplement with repeated clinical proof of raising testosterone in healthy men, not merely supporting levels. Cites mechanism (reduced SHBG and cortisol via hypothalamic-pituitary-gonadal axis) and six documented effects including 37% testosterone increase in 4 weeks at 200mg. Contrasts with multi-ingredient proprietary blends lacking clinical validation. Recommends 200-400mg standardized extract daily with breakfast, 100:1 or 200:1 extraction ratio, minimum 2% eurycomanone, cycling 5 days on 2 days off.
Source summary and thread relationship - @1immortals1 · 2026-08-03 original
Author suggests prison inmates' muscle gains are driven by psychological competitive/dominance behaviors elevating testosterone rather than dietary protein intake, dubbing these 'natural steroids.' Embedded quoted post by @Devsthetix asks how incarcerated people gain muscle mass without adequate protein.
Source summary and thread relationship - @lowmegatron · 2026-08-05 original
Mechanism by which thyroid hormone determines cavity susceptibility through effects on saliva quality and salivary gland function, with multiple animal and human study citations.
Source summary and thread relationship - @jamesbondwisdom · 2026-08-06 original
The author claims saw palmetto partially blocks 5-alpha reductase like finasteride but with no sexual side effects in trials. He gives 38% vs 68% improvement figures, finasteride side effects of up to 3.8%, a stack with pumpkin seed oil and nettle root, and a 320mg dose.
Source summary and thread relationship - @1immortals1 · 2026-08-06 original
Describes cistanche tubulosa herb mechanisms and historical use, citing modern clinical evidence for testosterone increase, sexual function, lifespan extension, BDNF upregulation, microbiome benefit, and zero toxicity. Provides dosage recommendation and price point.
Source summary and thread relationship - @jamesbondwisdom · 2026-08-07 original
The author claims sleeping under 7 hours accelerates hair loss. He cites lower growth hormone and testosterone, higher cortisol, more scalp inflammation and less melatonin, and advises 8 hours in a cool dark room.
Source summary and thread relationship - @1immortals1 · 2026-08-07 original
8-second sprint intervals on stationary bike produce 530% increase in growth hormone in single session via fast-twitch muscle fiber recruitment; 20 minutes 3x weekly yields superior hormonal and body composition results compared to longer steady-state cardio.
Source summary and thread relationship - @lowmegatron · 2026-08-08 original
Hypothyroid men have lower libido, lower sperm count, higher prolactin, and twice the prevalence of clinical hypogonadism (13.8% vs 6.5%); mechanism involves T3-mediated STAr protein expression in Leydig cells limiting cholesterol transport for testosterone synthesis; T3 addition to T4 therapy improves sexual desire in biochemically euthyroid men with persistent symptoms.
Source summary and thread relationship - @lowmegatron · 2026-08-08 original
Ray Peat anecdote on muscle gain inability in hypothyroidism; notes low testosterone and high cortisol shift body composition from muscle to fat; mentions thyroid hormone excess also causes muscle wasting.
Source summary and thread relationship - @1immortals1 · 2026-08-09 original
Morning sunlight exposure regulates circadian rhythm via photosensitive retinal ganglion cells signaling to suprachiasmatic nucleus; 2-10 minutes direct eye exposure within 30 minutes of waking sets cortisol, melatonin, testosterone and growth hormone timing for 24 hours; evening darkness reinforces the signal.
Source summary and thread relationship - @lowmegatron · 2026-08-10 original
Hypothyroid men have lower libido, lower sperm count, and higher prolactin; they are twice as likely to have clinically low testosterone. T3 enhances testosterone biosynthesis via STAr protein expression in Leydig cells. Correcting hypothyroidism can double testosterone and halve prolactin. Subclinical hypothyroidism (TSH 4.5–10) also causes sexual dysfunction. Adding T3 to T4 therapy improves sexual desire.
Source summary and thread relationship - @lowmegatron · 2026-08-10 original
Pregnenolone may help reduce alcohol cravings and anxiety in alcohol use disorder. A Ray Peat anecdote describes an alcoholic man whose anxiety and depression lifted after taking pregnenolone, describing it as 'the feeling I've been trying to get from alcohol, but it never worked.' Alcohol's calming effects are mediated through pregnenolone, DHEA, allopregnanolone, and progesterone. A human study (2023) found pregnenolone (300–500 mg/day) reduces stress-induced and alcohol cue-induced craving and normalizes HPA axis function. Author recommends Balancedbodymind, Raena, and Forefront Health pregnenolone brands, cautioning that many brands produce bad effects.
Source summary and thread relationship - @lowmegatron · 2026-08-12 own thread
The author claims vitamin C lowers stress-induced cortisol release and cites two PMIDs: excess vitamin C inhibits cortisol secretion after ACTH, and vitamin C was used in women with functional hypercortisolemia or elevated DHEA-S. The author prefers food sources such as fruit, juice and acerola powder.
Source summary and thread relationship - @lowmegatron · 2026-08-12 own thread
The author claims DHEA may lower 11β-HSD1 and local cortisol generation, quoting a paper suggesting some antidiabetic DHEA effects come from inhibiting glucocorticoid amplification in adipose tissue. The author suggests low doses (no more than 5 mg, 3x a day) because higher doses can increase estrogen.
Source summary and thread relationship - @lowmegatron · 2026-08-12 own thread
The author claims creatine reduces stress-induced cortisol increases. Quotes a study suggesting more than 5 days of creatine with resistance exercise increased testosterone and decreased cortisol concentrations.
Source summary and thread relationship - @lowmegatron · 2026-08-16 original
Ray Peat quote on bowel inflammation treatment including multiple interventions; followed by discussion of lidocaine gel for ulcerative colitis with multiple clinical study summaries showing rapid symptom relief, mucosal healing, and lymphocyte depletion with 83% response rate in larger trial.
Source summary and thread relationship - @lowmegatron · 2026-08-17 original
Author lists interventions claimed to decrease chronically elevated cortisol, including light exposure, dietary fats, micronutrients, supplements, and lifestyle factors. Quoted source discusses mold-induced stress lowering thyroid hormone T3 conversion and successful T3 supplementation in four patients previously unresponsive to levothyroxine.
Source summary and thread relationship - @lowmegatron · 2026-08-18 original
Author claims pregnenolone synthesis from cholesterol depends on thyroid hormone, and hypothyroidism throttles this conversion, lowering sex hormones and increasing pain, depression, and anxiety. Cites study showing lower DHEA, DHEA-S, and pregnenolone sulfate in hypothyroid patients.
Source summary and thread relationship - @jamesbondwisdom · 2026-08-18 original
The author recounts James Hamilton's 1942 observations that castrated men did not develop pattern baldness and that testosterone triggered loss in genetically predisposed men. He concludes that DHT acting on vulnerable follicles causes male pattern baldness and that finasteride, saw palmetto and ketoconazole target this mechanism.
Source summary and thread relationship - @lowmegatron · 2026-08-19 original
Pregnenolone increases deep sleep by converting to progesterone and allopregnanolone, exerting anti-cortisol and pro-GABA effects. Studies show pregnenolone increases slow-wave sleep, improves sleep efficiency, and reduces intermittent wakefulness. Progesterone restores normal sleep when disturbed without inhibiting deep sleep like hypnotic drugs. Achieving maximum plasma allopregnanolone requires 1,600 mg progesterone daily.
Source summary and thread relationship - @jamesbondwisdom · 2026-08-19 original
The author tells the story of Julianne Imperato-McGinley's 1974 study of guevedoces in the Dominican Republic, who lack 5-alpha reductase, have normal testosterone and reportedly never go bald. He says this led Merck to develop finasteride, which shows baldness depends on one blockable enzyme step.
Source summary and thread relationship - @jamesbondwisdom · 2026-08-20 original
The author claims DHT drives beard growth yet causes scalp follicle miniaturization in genetically predisposed men, which he calls the androgen paradox. He says effective treatments target DHT rather than testosterone.
Source summary and thread relationship - @1immortals1 · 2026-08-20 original
Author reports vitamin D supplementation raised testosterone 25% (and free testosterone 20%) in a year-long placebo-controlled trial, explains direct mechanism via vitamin D receptors on testis, pituitary, and hypothalamus, and recommends checking vitamin D levels before buying testosterone boosters.
Source summary and thread relationship - @1immortals1 · 2026-08-23 original
Ashwagandha root extract reduces cortisol 27% and raises testosterone 15% in controlled trials; mechanism involves cortisol-testosterone competition for shared precursor resources; extract improves sleep, muscle gain, and strength in clinical studies.
Source summary and thread relationship - @lowmegatron · 2026-08-25 original
TRH increases blood pressure, resting pulse, and prolactin, which can lower testosterone and progesterone. TRH rises when thyroid hormones are low and stimulates TSH. When the thyroid does not adequately respond, TRH remains elevated. The embedded quoted post describes a patient's experience with T3 supplementation improving sleep quality and reducing nocturnal symptoms.
Source summary and thread relationship - @lowmegatron · 2026-08-28 original
Thyroid hormone accelerates alcohol detoxification and affects neurosteroid production (pregnenolone, DHEA, progesterone, allopregnanolone), which mediate anxiety relief and intoxication effects. Hyperthyroidism markedly increases ethanol metabolism rate.
Source summary and thread relationship - @1immortals1 · 2026-08-29 original
Nigella sativa (black seed) contains thymoquinone, which modulates NF-κB and shows effects across inflammation, metabolism, liver function, immune response, and infection. Over 1000 peer-reviewed studies document anti-inflammatory activity comparable to ibuprofen, blood sugar reduction comparable to metformin, liver protection, immune modulation and antimicrobial effects. Recommended 1 teaspoon cold-pressed black seed oil daily at $12/month; not patentable so not adopted by pharmaceutical medicine.
Source summary and thread relationship - @1immortals1 · 2026-08-30 original
Boron supplementation increased free testosterone by 28% and decreased free estrogen by 39% in one week clinical trial by reducing SHBG production and shifting estrogen metabolism to weaker forms.
Source summary and thread relationship - @1immortals1 · 2026-08-30 original
Tongkat Ali (Eurycoma longifolia) reduced cortisol by 16% and increased testosterone by 37% in a 4-week trial by lowering cortisol and SHBG, not by increasing testosterone production.
Source summary and thread relationship - @lowmegatron · 2026-09-02 original
Ray Peat quote: Thyroid tends to lower cholesterol by converting it into pregnenolone and other steroids. Embedded quote discusses pregnenolone's effects on skin aging and health; Ray Peat personal account of pregnenolone's dramatic symptom relief from inflammatory conditions and associated facial rejuvenation.
Source summary and thread relationship - @jamesbondwisdom · 2026-09-03 original
The author claims stinging nettle root blocks DHT via 5-alpha reductase inhibition, SHBG effects and beta-sitosterol, calls it comparable to finasteride for prostate symptoms, and suggests 300–600 mg root extract daily, naming NOW Foods and Swanson.
Source summary and thread relationship - @1immortals1 · 2026-09-05 original
Zinc is required for 300+ enzymatic reactions including testosterone production, immune function, DNA synthesis, wound healing, and neurotransmitter regulation; ~2 billion people globally are zinc deficient with no body storage reserves. RDA 11 mg prevents deficiency; functional practitioners recommend 15-30 mg for optimization in athletes and plant-based dieters.
Source summary and thread relationship - @lowmegatron · 2026-09-07 original
Author warns against attributing negative effects to pregnenolone itself; cites Ray Peat quote attributing adverse reactions to product impurity decline since 2013. Embedded post by dannyroddy discusses pregnenolone quality degradation and suggests progesterone and DHEA alternatives.
Source summary and thread relationship - @lowmegatron · 2026-09-07 original
Bioidentical progesterone reduces anxiety and increases pro-social and exploratory behaviors in mice via increased allopregnanolone (5α-reductase metabolite); synthetic progestin (MPA) does not produce this effect because it does not serve as substrate for 5α-reductase. Neurosteroid effects may be relevant to sex differences in neuropsychiatric and neurodegenerative disorders. Embedded post discusses thyroid hormone's role in alcohol detoxification and neurosteroid production.
Source summary and thread relationship - @jamesbondwisdom · 2026-09-08 original
jamesbondwisdom recounts Hamilton's 1942 observations of castrated men to argue that pattern baldness requires androgens/DHT. He says genetics determine susceptibility, that follicles are suppressed rather than dead, and that DHT blockers follow from this work. He criticizes the transplant industry as unnecessary. These are source claims.
Source summary and thread relationship - @lowmegatron · 2026-09-09 original
Hypothyroidism lowers pregnenolone and downstream steroid hormones (DHEA, testosterone, estrogen) with implications for mood, mental illness, reproduction, libido, dementia risk, substance abuse, aging, appearance, and muscle mass. StAR protein shuttles cholesterol into mitochondria to make pregnenolone; thyroid hormone T3 regulates StAR. Study shows serum ADIOLS, ADIOL, DHEAS, DHEA, and pregnenolone sulfate are decreased in hypothyroidism. Embedded quoted account lists hormones derived from pregnenolone.
Source summary and thread relationship - @1immortals1 · 2026-09-10 original
DHEA (dehydroepiandrosterone) declines 2-3% annually starting in late twenties; by 40, individuals have 50% of peak levels; by 70, 10-20%. DHEA is the precursor for testosterone, estrogen, and 50+ other hormones. Decline (adrenopause) causes fatigue, reduced recovery, declining libido, muscle loss, mood changes. Journal of Clinical Endocrinology study: DHEA supplementation in adults over 40 improved bone density, skin thickness, sexual function, and wellbeing within 6 months; improvements reversed upon cessation. Recommended dose: 25mg daily for women, 50mg for men, taken in morning. Cost approximately $8 for 3-month supply ($0.09/day).
Source summary and thread relationship - @jamesbondwisdom · 2026-09-10 original
jamesbondwisdom claims fenugreek, as topical paste or oral extract, reduced hair fall 83.3% in 6 months. He attributes this to diosgenin inhibiting 5-alpha reductase, plus phytoestrogens, mucilage, lecithin and nicotinic acid. He compares it favorably with finasteride on cost and sexual side effects and gives a protocol. These are source claims.
Source summary and thread relationship - @lowmegatron · 2026-09-11 own thread
lowmegatron says that in the 1930s G. K. Wharton reported improvements in a long list of symptoms (migraine, menstrual irregularities, dry skin and hair, acne, fatigue, low libido and others) in cases of hypothyroidism that the standards of the day did not recognize. The parent posts discuss Barnes, NDT and basal temperature, but this post does not itself mention them.
Source summary and thread relationship - @jamesbondwisdom · 2026-09-15 original
The author claims spearmint tea twice daily lowered free testosterone by 30% in 30 days in women with elevated androgens. The post attributes this to rosmarinic acid inhibiting 5-alpha-reductase and modulating SHBG. It compares the tea favorably with finasteride on cost and side effects and gives brewing and dosing instructions. It also claims benefits for scalp oiliness and PCOS and says hair changes appear at 8 to 12 weeks.
Source summary and thread relationship - @1immortals1 · 2026-09-18 original
Cistanche tubulosa described as traditional Chinese imperial herb for sexual vitality and longevity; mechanisms, human and animal study results, and longevity claims presented; specific extract dosing and purchasing recommendations provided with price estimates and retailer names.
Source summary and thread relationship - @jamesbondwisdom · 2026-09-19 original
The author claims pygeum africanum bark extract blocks DHT via 5-alpha reductase inhibition and receptor blocking comparably to finasteride, with no sexual side effects, and that it was sidelined because it cannot be patented. Gives dosing and brands.
Source summary and thread relationship - @1immortals1 · 2026-09-19 original
The author claims supplementing zinc without copper depletes copper and can cause deficiency (anemia, connective tissue, neurological problems, early graying), and proposes copper supplementation at roughly a 15:1 zinc:copper ratio. Mentions zinc's benefit for testosterone only in passing.
Source summary and thread relationship - @1immortals1 · 2026-09-26 own thread
1immortals1 asks readers to follow for more on maca, natural libido support, energy, and the science behind supplements.
Source summary and thread relationship - @1immortals1 · 2026-09-29 original
1immortals1 claims stinging nettle root lignans displace testosterone from SHBG, raising free testosterone without raising total. The post also says it inhibits aromatase and reduces prostate inflammation, and that standard total-testosterone tests miss high SHBG. It contrasts nettle root with TRT costs and recommends 300-600mg of root extract daily.
Source summary and thread relationship - @1immortals1 · 2026-09-29 own thread
1immortals1 asks readers to follow for more hormone and health breakdowns like the parent post. The post itself names no specific hormone.
Source summary and thread relationship - @1immortals1 · 2026-09-29 original
DIM (diindolylmethane) from cruciferous vegetables shifts estrogen metabolism from harmful (16α-hydroxyestrone) to protective (2-hydroxyestrone) pathway; author recommends 100–200mg daily ($0.20/day) as modulation alternative to pharmaceutical aromatase inhibitors.
Source summary and thread relationship - @1immortals1 · 2026-09-29 own thread
1immortals1 asks readers to follow for more on male hormones, estrogen, and how they can affect the body.
Source summary and thread relationship