Selenium, Zinc, Copper and Iron
172 associated posts. These are attributed summaries; original text remains at the linked X post and in the local archive.
- @lowmegatron · 2025-10-06 original
The author says thyroid hormones, specifically levothyroxine, help lower Hashimoto's antibodies and thyroid inflammation. Excerpts from three named papers are quoted in support. The author adds that levothyroxine plus TSH testing is usually not the best approach and that treatment focused on T3 activity will likely work even better.
Source summary and thread relationship - @lowmegatron · 2025-10-08 original
Author says light therapy plus supplements beat supplements alone in a Turkish human study of Hashimoto's, with higher T3, higher T3/T4 ratio, lower TPOAb and lower L-thyroxin dose. The post gives the laser protocol and comments on the supplements used.
Source summary and thread relationship - @lowmegatron · 2025-10-08 original
Author reports a Kosovo study in which three weeks of near-infrared light therapy added to selenium/vitamin D was followed by improved thyroid labs and reduced weight and waist measures in Hashimoto's. The post gives the light parameters and says weight fell further at 6 months.
Source summary and thread relationship - @lowmegatron · 2025-10-08 original
Author reports a Kosovan study in which three weeks of near-infrared light therapy plus supplements was followed by lower thyroid volume and improved thyroid labs in Hashimoto's. The post says the share of patients with normal thyroid volume rose from 17% to 96% at 6 months.
Source summary and thread relationship - @lowmegatron · 2025-10-09 own thread
lowmegatron claims light therapy outperformed selenium, vitamin D and iron in Hashimoto's. He reports T3 up 54%, T3/T4 ratio up 44%, TPOAb down 73%, and T4 needs down 50%.
Source summary and thread relationship - @lowmegatron · 2025-10-11 original
Author posts a checklist of factors for thyroid hormone T3: carbohydrates, calories, several vitamins and minerals, low stress, and moderate protein.
Source summary and thread relationship - @lowmegatron · 2025-10-13 original
The author promotes the Hypothyroid Masterclass, a video course with a support community, aimed at people whose thyroid labs are 'normal' but who feel hypothyroid. The post lists the course modules. The quoted post is only a link.
Source summary and thread relationship - @lowmegatron · 2025-10-14 original
The post quotes Ray Peat saying the skin test for iodine deficiency is unscientific because reductants convert iodine to colorless iodide. The embedded quoted post from lowmegatron quotes text linking excess iodide to autoimmune thyroiditis and adds a bracketed comment about selenium, vitamins C and E, and polyunsaturated fats.
Source summary and thread relationship - @lowmegatron · 2025-10-15 original
The author promotes oysters for immunity on the claim that age-related relative zinc deficiency lowers immunity and that zinc acts as an aromatase inhibitor, which blocks estrogen-driven thymus loss. They quote two rodent-marked passages on zinc supplementation and estradiol-induced thymus shrinkage. The embedded post is lowmegatron's aromatase-inhibitor and thymus post.
Source summary and thread relationship - @lowmegatron · 2025-10-16 original
Author claims cortisol shrinks the thymus, lowering protective immunity and raising autoimmunity risk, with changes resembling aging, citing a quoted finding on lymphocyte loss after cortisol injection. The embedded post (lowmegatron) argues zinc, from sources like oysters, may protect the thymus and estrogen shrinks it.
Source summary and thread relationship - @lowmegatron · 2025-10-16 original
The author lists supplements, foods and habits they say protect against polyunsaturated fat (PUFA) and seed oil effects. The lists cover reducing lipid peroxidation, lowering free fatty acids and supporting glucuronidation and sulfation. The author also advises eating mostly saturated fats and avoiding high-PUFA oils. The embedded lowmegatron post has an overlapping saturated fat/PUFA list plus a note on olive oil.
Source summary and thread relationship - @lowmegatron · 2025-10-17 original
The author says zinc helps regenerate the aging thymus and that zinc supplements reduce infection in older people, who tend to be low in zinc, citing PMID 17344507. The author notes copper intake must be adjusted with more zinc. The embedded lowmegatron post adds oysters as a zinc source, zinc as an aromatase inhibitor, and estrogen shrinking the thymus, citing animal data.
Source summary and thread relationship - @lowmegatron · 2025-10-21 original
The post advertises the Hypothyroid Masterclass, described as teaching practical testing, nutrition and dosing concepts with a support community, and lists its video modules. The embedded quoted post from lowmegatron contains only an emoji and a t.co link.
Source summary and thread relationship - @lowmegatron · 2025-10-25 original
Author says optimizing zinc levels can help prevent atherosclerosis by lowering lipid peroxidation and inflammation, noting a study used 45 mg/day zinc gluconate for six months and that high zinc should be balanced with copper. The quoted lowmegatron post claims zinc supplementation regenerates the aging thymus and reduces infection in older people.
Source summary and thread relationship - @lowmegatron · 2025-10-26 original
The post is only a thread title and link on selenium, thyroid hormones, autoimmunity and Hashimoto's. No substantive health claims are in the retrieved text.
Source summary and thread relationship - @lowmegatron · 2025-10-26 own thread
lowmegatron claims selenium is required for thyroid hormone conversion and that a deficiency can cause hypothyroid symptoms even without a diagnosis. He also claims selenium calms autoimmune thyroid processes (Hashimoto's, Graves', thyroid eye disease) and can speed normalization of thyroid hormones during extreme stress.
Source summary and thread relationship - @lowmegatron · 2025-10-26 own thread
lowmegatron describes a 3-month study of 70 women with Hashimoto's antibodies, all on T4. Half received 200 mcg sodium selenite daily and half a placebo. He reports normal antibodies in 25% of the selenium group versus 6% of the placebo group, and a 34% versus 12% fall in TPO antibodies. Thyroid hormones were unchanged. He calls this a '4x remission rate' and quotes the authors' conclusion.
Source summary and thread relationship - @lowmegatron · 2025-10-26 own thread
lowmegatron describes a case study of a woman with Hashimoto's given 50-100 mcg of selenium daily for 14 months. He says 50 mcg had little effect, while 100 mcg cut TPO antibodies by 76%, and that her antibodies rose after supplementation stopped.
Source summary and thread relationship - @lowmegatron · 2025-10-26 own thread
lowmegatron argues selenium's thyroid benefits likely come mainly from immune modulation and effects on reactive oxygen species in the gland, and says it may reduce postpartum thyroiditis. He quotes a review saying supplementation lowers anti-thyroid antibodies in Hashimoto's and in pregnant women with anti-TPO antibodies.
Source summary and thread relationship - @lowmegatron · 2025-10-26 own thread
lowmegatron claims selenium may help autoimmune hyperthyroidism. He says patients given antioxidants including selenium alongside anti-thyroid drugs reached normal hormone levels faster, and that Graves' status correlates with blood selenium. He cites a Graves' orbitopathy trial of 200 μg/day sodium selenite with improved quality of life (over 70% vs 22%) and orbital lesions (61% vs 35%).
Source summary and thread relationship - @lowmegatron · 2025-10-26 own thread
lowmegatron states that supplementing selenium at 500 mcg/day during acute stress, such as a surgical ICU stay, speeds recovery of normal T4 and T3 levels.
Source summary and thread relationship - @lowmegatron · 2025-10-26 own thread
lowmegatron claims that combining selenium and myo-inositol reduces thyroid antibodies, lowers TSH and raises thyroid hormones in hypothyroid people, and that it appeared to normalize TSH in a hyperthyroid patient. He also says low selenium and myo-inositol may predispose to hypothyroidism. He gives food amounts he says supply the study doses (83 μg selenium; 600 mg myo-inositol).
Source summary and thread relationship - @lowmegatron · 2025-10-31 original
The author quotes Ray Peat saying hair binds copper from air and water, so hair mineral tests are invalid, and that toenails are better. Peat recommends weekly shellfish to keep copper adequate. The quoted context is a Peat remark that zeolite in stomach acid can itself be a source of toxins.
Source summary and thread relationship - @lowmegatron · 2025-11-01 original
The post reproduces a long Ray Peat passage claiming caffeine and coffee are protective and nutrient-like, with effects on the thyroid, liver, cancer, progesterone, Parkinson's disease, iron and cell death. An embedded post from lowmegatron cites a prospective cohort study linking higher coffee intake to lower gout risk.
Source summary and thread relationship - @lowmegatron · 2025-11-01 original
The author quotes Ray Peat saying hair mineral analysis mainly reflects what the hair is washed with, that toenails are more representative, and that whole blood including blood cells is more reliable. He adds an image from PMID 26711619 showing about 3x more calcium and 4x more magnesium in hair washed with hard versus soft water.
Source summary and thread relationship - @lowmegatron · 2025-11-01 original
The post contains only a t.co link and a quoted earlier post from lowmegatron. The quoted post carries Ray Peat's statements that HTMA reflects hair washing rather than body minerals. The sharing account adds no visible commentary.
Source summary and thread relationship - @nootropicguy · 2025-11-02 own thread
nootropicguy lists 'honorable mentions' for ADHD beyond Adderall: zinc (30mg claimed to cut stimulant dose by 37%), a 36-in-1 micronutrient (benefit in 3 human trials), magnesium (claims up to 95% of ADHD kids are deficient), vitamin D (modest add-on benefit in 4 trials) and phosphatidylserine (small benefit at 200mg/day).
Source summary and thread relationship - @lowmegatron · 2025-11-09 original
The author lists claimed effects of high prolactin, its claimed causes (stress, serotonin, hypothyroidism, low zinc, seed oils, etc.) and things he says may lower it (zinc, DHT, coffee, aspirin, bright light, progesterone, thyroid optimization, etc.).
Source summary and thread relationship - @lowmegatron · 2025-11-09 original
The author states that cortisol, adrenaline and glucagon inhibit thyroid hormone conversion, and lists common causes: chronic caloric restriction, low carbohydrate, poor sleep, low magnesium/potassium/calcium/sodium, and fasting. The quoted post (lowmegatron) cites Ray Peat saying stress can block T4-to-T3 conversion.
Source summary and thread relationship - @lowmegatron · 2025-11-10 original
The post quotes Ray Peat saying serotonin reuptake inhibitor antidepressants increase prolactin and were found to cause osteoporosis after prolonged use. The embedded lowmegatron post lists symptoms attributed to high prolactin, causes of high prolactin, and factors said to lower it.
Source summary and thread relationship - @lowmegatron · 2025-11-12 original
The author claims polyunsaturated fats such as linoleic and arachidonic acid interfere with vitamin D binding to DBP, while saturated fats do not. The embedded lowmegatron post lists strategies to protect against seed oils and polyunsaturated fats, including supplements, foods and fats to eat or avoid.
Source summary and thread relationship - @lowmegatron · 2025-11-12 original
Author shares a Ray Peat quote saying inositol seems safe at a few grams/day and may protect against cataracts, and adds that inositol can help lower thyroid autoimmunity. The quoted lowmegatron post claims selenium plus myo-inositol lowers thyroid antibodies and TSH in hypothyroidism, and gives dietary sources.
Source summary and thread relationship - @lowmegatron · 2025-11-14 original
Post quotes Ray Peat on atrial fibrillation: vitamins D, K and calcium stabilize heart rhythm, estrogen promotes hyperventilation and AF tendency, progesterone opposes it, thyroid helps cells retain magnesium, and milk, orange juice and seafood supply stabilizing minerals.
Source summary and thread relationship - @lowmegatron · 2025-11-16 original
Post shares a Ray Peat quote on improving thyroid hormone conversion: selenium deficiency correction works quickly, intestinal flora problems must be addressed, and other nutritional factors such as daily raw carrot, weekly seafood and liver, sunlight, vitamin D and calcium-to-phosphate balance are often helpful. The embedded post is a lowmegatron thread on selenium and thyroid, whose content is not included.
Source summary and thread relationship - @lowmegatron · 2025-11-21 original
Author lists conditions said to be caused by bacterial endotoxin entering the bloodstream in leaky gut, then lists nutrients, drugs, foods and lifestyle factors said to reduce endotoxin or its inflammatory effects. The embedded post claims pregnenolone curbs alcohol cravings partly through TLR4 inhibition.
Source summary and thread relationship - @lowmegatron · 2025-11-22 original
Author describes a case report of a woman whose manic symptoms after gastrectomy for obesity reportedly resolved within two weeks on 1 g/day activated charcoal, with a quoted mechanism proposing a brain–gut axis. The embedded lowmegatron post claims bacterial endotoxin from leaky gut causes many conditions and lists interventions said to help with endotoxin.
Source summary and thread relationship - @lowmegatron · 2025-11-24 original
The author claims that reducing excess iron lowers cancer risk, citing reductions in cancer deaths, incidence and all-cause mortality (PMID 18612130). They say iron promotes lipid peroxidation of PUFAs. They quote Ray Peat's advice on vitamin E, coffee, unsaturated fats, vitamin C and copper in relation to iron. The embedded lowmegatron post claims coffee protects DNA by lowering lipid peroxidation, citing a randomized study.
Source summary and thread relationship - @lowmegatron · 2025-11-24 original
The author advertises the Hypothyroid Masterclass, a video course with a support community, aimed at people with normal thyroid labs who still feel hypothyroid. Most of the post is a list of module topics.
Source summary and thread relationship - @lowmegatron · 2025-11-25 original
The author claims much mental illness begins in the gut because bacterial endotoxin poisons mitochondria and leaky gut lets more endotoxin into circulation. They quote a systematic review and meta-analysis on gut dysbiosis markers in severe mental illness and chronic fatigue. They then list nutrients, foods and other factors they say reduce endotoxin or endotoxin-driven inflammation.
Source summary and thread relationship - @lowmegatron · 2025-11-26 original
The author lists nutrients, foods and other factors they say can help with high histamine, including correcting hypothyroidism and estrogen dominance. The embedded post from lowmegatron introduces a thread on histamine hacks and lists conditions in which histamine is implicated.
Source summary and thread relationship - @lowmegatron · 2025-11-26 original
The posting author argues that seed oil (linoleic acid) intake probably plays a large role in Hashimoto's susceptibility, citing a rodent study where a high-linoleic-acid diet was followed by thyroid autoimmunity and hypothyroidism. The author links this to lipid peroxidation and says seed oils are tied to other autoimmune diseases partly via pro-estrogenic properties. The embedded quoted post (lowmegatron) cites register data on suicide and unknown-cause death in Hashimoto's and gives that account's opinion that inadequate treatment, T3 and temperature are involved.
Source summary and thread relationship - @lowmegatron · 2025-11-26 original
The post claims that lowering iron, via phlebotomy, reduces insulin resistance in people with NAFLD, quoting a paper. The author adds a mechanism: iron plus seed oils creates a pro-oxidative environment that forms lipid peroxides such as 4-HNE and damages mitochondria and insulin signaling. The embedded quoted post (lowmegatron) cites iron reduction and lower cancer risk and includes a Ray Peat quote on iron, vitamin E, coffee, vitamin C and copper.
Source summary and thread relationship - @lowmegatron · 2025-11-28 original
The post excerpts a case report of a 54-year-old hypothyroid woman with paroxysmal atrial fibrillation whose palpitations and AF episodes reportedly improved after 6 weeks of levothyroxine. It notes that hypothyroidism may contribute to arrhythmia and that excess thyroid hormone also causes Afib. The embedded quoted post (lowmegatron) gives a Ray Peat quote on nutrients and hormones affecting atrial fibrillation.
Source summary and thread relationship - @lowmegatron · 2025-11-29 original
The post claims rosacea and other skin conditions are often due to gut events, citing a Ray Peat quote on bacterial endotoxin and a case report of rosacea remission after reduced bowel transit time. The embedded quoted post (lowmegatron) lists conditions attributed to endotoxin from leaky gut and a long list of substances said to help with endotoxin.
Source summary and thread relationship - @lowmegatron · 2025-11-29 original
The author promotes the Hypothyroid Masterclass, a video course with a support community covering practical testing, nutrition and dosing concepts. The post mainly lists the module titles. The embedded lowmegatron post contains only an emoji and a link.
Source summary and thread relationship - @lowmegatron · 2025-11-30 own thread
lowmegatron lists factors he claims help control endotoxin. These include optimizing T3, coffee (including decaf), a low omega-6 diet, vitamin C, aspirin, fixing sleep and circadian disorganization, activated charcoal, naringenin, benfotiamine, glycine, aged cascara sagrada, cooked mushrooms, progesterone, pregnenolone and zinc.
Source summary and thread relationship - @lowmegatron · 2025-12-01 original
The author claims Wi-Fi and cell-signal EMF trigger lipid peroxidation, contributing to several diseases, and that zinc and vitamins C/E help protect cells; the author recommends distance. The embedded lowmegatron post links higher coffee intake to lower cirrhosis risk and lists proposed mechanisms.
Source summary and thread relationship - @lowmegatron · 2025-12-02 own thread
lowmegatron gives a list of claimed ways to lower serotonin. He says PUFAs, estrogen, vitamin E or B1 deficiency and elevated free fatty acids raise it. He says zinc, niacinamide, aspirin, creatine, gelatin/glycine, vitamin E, vitamin D, L-theanine, inosine, coffee with food, calcium, magnesium, aged cascara sagrada, quinine, lysine and ginger lower it or help. He names antiserotonin drugs lisuride, cyproheptadine, memantine and famotidine.
Source summary and thread relationship - @lowmegatron · 2025-12-02 own thread
lowmegatron calls zinc a key nutrient for optimizing prolactin. He quotes a study in which zinc-treated patients had higher plasma zinc and lower serum prolactin, with an inverse relationship between the two.
Source summary and thread relationship - @lowmegatron · 2025-12-05 original
Post quotes Ray Peat saying hypothyroidism involves poor absorption and retention of magnesium, sodium and copper. He says extra sodium raises body temperature, lowers aldosterone, helps retain magnesium and improves cell response to thyroid hormone. He adds that low sodium raises adrenaline while enough sodium lowers adrenaline and improves sleep.
Source summary and thread relationship - @lowmegatron · 2025-12-05 original
The author claims zinc is overlooked in thyroid status and may independently contribute to hypothyroid hair loss. He cites studies on zinc preventing exercise-related drops in thyroid hormones, zinc opposing melatonin's thyroid suppression, and zinc raising T3. He speculates zinc helps T4-to-T3 conversion.
Source summary and thread relationship - @lowmegatron · 2025-12-11 original
The post quotes Ray Peat on accumulated unstable fats making endotoxin exposure more inflammatory and stressing the lipid-rich brain with age. The embedded quote, from lowmegatron, lists conditions attributed to endotoxin from leaky gut and a long list of nutrients, drugs and habits said to help.
Source summary and thread relationship - @lowmegatron · 2025-12-15 original
The author says high-dose zinc supplementation normalized T3 and lowered reverse T3 in people with zinc deficiency, and that zinc deficiency may cause hypothyroid symptoms by impairing T4-to-T3 conversion. The author notes this was a high dose in confirmed zinc deficiency. The embedded post (lowmegatron) lists a thyroid T3 checklist.
Source summary and thread relationship - @lowmegatron · 2025-12-16 own thread
lowmegatron promotes his Hypothyroid Masterclass Group, listing video modules on hypothyroidism symptoms and causes, blood tests and their problems, pulse and temperature, T3 activity, autoimmunity, conversion, reverse T3, T4/NDT/T3 supplementation, nutrition (iron, iodine, selenium, PUFA), stress, and drugs affecting thyroid hormones.
Source summary and thread relationship - @lowmegatron · 2025-12-17 original
The author claims sodium deficiency can cause insulin resistance and rapidly raise noradrenaline and aldosterone. They cite a study (PMID 21036373) where healthy people on a low-salt diet had higher HOMA-IR and 50% higher aldosterone. The embedded Ray Peat quote links sodium intake to aldosterone, magnesium retention, adrenaline and sleep in hypothyroidism.
Source summary and thread relationship - @lowmegatron · 2025-12-17 original
The author argues that some hypothyroidism is reversible with iodine restriction and that excess iodine is as harmful as deficiency. They cite a study in which 12 of 22 patients became euthyroid after 3 weeks of iodine restriction, and in which reintroducing 25 mg iodine daily made them hypothyroid again. They add Ray Peat and a review on excess iodine and autoimmune thyroiditis. They say selenium or vitamin E reduce the risk but do not fully prevent it. The embedded post from lowmegatron covers iodine intake and hypothyroidism rates in Japan and risk factors for iodine-induced thyroid dysfunction.
Source summary and thread relationship - @lowmegatron · 2025-12-18 original
The post quotes Ray Peat on parathyroid hormone, calcium and vitamin D (high calcium intake compensating for low vitamin D, both vitamin D and dietary calcium tending to lower PTH), and on soft-tissue calcification (calciphylaxis) involving estrogen, histamine, serotonin and iron. It notes the image shows a calcified rat from Hans Selye's experiments. The embedded lowmegatron post claims PTH deposits calcium in soft tissues.
Source summary and thread relationship - @nootropicguy · 2025-12-20 original
The author announces AURABIŌM, a product developed with a tagged account, described with claims of diamond peptides with 90x bioavailability, micro copper peptides with 3x penetration, and 10+ peptides plus stem cells. It introduces a thread, and the retrieved text gives no explanatory health content.
Source summary and thread relationship - @lowmegatron · 2025-12-21 original
The author claims vitamin D plus calcium supplementation reduced cancer diagnoses by 60% in older women, citing a 4-year randomized placebo-controlled trial (PMID 17556697). The embedded post by lowmegatron relays Ray Peat quotes on PTH, vitamin D, calcium, milk intake and soft-tissue calcification.
Source summary and thread relationship - @lowmegatron · 2025-12-22 original
The author says nutrition matters even when taking thyroid hormone. The quoted account (_palmerprescott) describes T3 having no effect for over a year until about a week of zinc supplementation.
Source summary and thread relationship - @lowmegatron · 2025-12-22 original
The author cites a paper suggesting that stress-related high histamine combined with vitamin C depletion damages arterial endothelium and predisposes to atherosclerosis and myocardial infarction. The author lists agents said to help lower histamine, depending on context, and common causes of elevated histamine.
Source summary and thread relationship - @lowmegatron · 2025-12-23 original
The author argues that seed oils (linoleic acid) amplify alcoholic liver damage while saturated fats are protective. Support cited is a rat study, a 60-day randomized trial in severe alcoholic hepatitis comparing ghee with soybean oil, and a quoted Ray Peat excerpt.
Source summary and thread relationship - @lowmegatron · 2025-12-28 original
The author claims copper dissolves in human sweat and may be absorbed from copper jewelry. They claim copper optimization benefits immunity, energy, thyroid and cardiovascular health. They quote a study on sweat copper solubility and weight loss of copper bracelets, and a Ray Peat quote on iron and copper interaction.
Source summary and thread relationship - @lowmegatron · 2025-12-29 own thread
lowmegatron argues that questions about hypothyroidism lack one-size-fits-all answers and that anyone offering broad solutions doesn't understand the problem. He promotes his Hypothyroid Masterclass Course, described as 31 short video modules, and lists the topics covered (tests, conversion, reverse T3, T4/NDT/T3 supplementation, nutrients, PUFA, stress, diet, drugs).
Source summary and thread relationship - @lowmegatron · 2026-01-03 original
The author describes selenium as required for thyroid hormone conversion and as protective of the thyroid. They say deficiency may cause hypothyroid-like symptoms and that supplementation may lower thyroid antibodies in autoimmune thyroid disease, help Graves' eye disease, and speed recovery of thyroid hormones in acute stress. They also list selenium-rich foods and note an upper limit of 400 mcg/day.
Source summary and thread relationship - @lowmegatron · 2026-02-02 original
Kelp capsules suppress thyroid function via excessive iodine intake, with mechanism of iodine-induced hypothyroidism. Embedded post details iodine restriction reversibility of hypothyroidism in some patients, lipid peroxidation role, and Ray Peat commentary on excess iodine toxicity and autoimmune thyroiditis.
Source summary and thread relationship - @lowmegatron · 2026-02-06 original
Repost of shortbusfanatic's personal experience report: T3 and B1 supplementation after zinc status correction resolved chronic/seasonal nasal issues previously unresponsive to antihistamines.
Source summary and thread relationship - @lowmegatron · 2026-02-11 original
Quoted Ray Peat claims that diet and hormones interact; magnesium uptake requires adequate vitamin D and T3; T3 production requires selenium and sugar; pregnenolone and progesterone support T3 effects; cyproheptadine blocks stress mediators from hormonal-nutritional deficiencies; excess phosphate relative to calcium and magnesium creates tension.
Source summary and thread relationship - @lowmegatron · 2026-02-19 original
Author quotes Ray Peat on varying individual reactions to alcohol depending on thyroid activity, noting antioxidant vs. pro-oxidative effects and interaction with polyunsaturated fat consumption. Contextualizes linoleic acid as abundant polyunsaturated fat in soybean and seed oils. Includes embedded quote on thyroid hormone correcting alcohol intolerance and preventing hypoglycemia.
Source summary and thread relationship - @lowmegatron · 2026-02-26 original
Selenium supplementation (200 mcg sodium selenite) helps lower Hashimoto's antibodies; 25% of women achieved normal antibody levels compared to 4× placebo; improves inflammatory activity in autoimmune thyroiditis; recommends checking baseline selenium intake before supplementing due to risk of excess.
Source summary and thread relationship - @lowmegatron · 2026-03-03 original
Zinc protects against stress-induced decrements in thyroid hormones and testosterone and improves weight loss, inflammation, and insulin sensitivity in obese people in caloric deficit. Two studies quoted on zinc supplementation effects. Embedded quoted post details high-dose zinc effects on T3, reverse T3, and thyroid hormone conversion in zinc-deficient people.
Source summary and thread relationship - @lowmegatron · 2026-03-04 original
Author provides historical narrative of iodine's identification (1812) and thyroid use (1816); embeds extensive quoted content on iodine's adverse effects, importance of caution, mechanisms of iodine-induced hypothyroidism, and the distinction between iodine deficiency and excess.
Source summary and thread relationship - @lowmegatron · 2026-03-09 original
Author lists micronutrients, macronutrients, and lifestyle factors (sleep, stress) claimed to optimize thyroid hormones and prevent T3 suppression. Quotes lowmegatron on cortisol's anti-thyroid mechanisms.
Source summary and thread relationship - @lowmegatron · 2026-03-12 original
Testosterone supplementation reduces thyroid antibodies (TPOAb and TgAb) in men with low testosterone and Hashimoto's disease. Selenium alone also reduces antibodies but testosterone produces greater reduction.
Source summary and thread relationship - @lowmegatron · 2026-03-14 original
Author lists interventions reported to lower thyroid antibodies (TPOAb, TGAb) with effect sizes, including near-infrared light, vitamin D, selenium, vitamin C, testosterone in deficient men, and levothyroxine; notes LDN, gluten removal, and dairy removal help a minority.
Source summary and thread relationship - @lowmegatron · 2026-03-19 original
Selenium deficiency causes thyroid hormone problems and insulin resistance. In type 2 diabetes patients with coronary heart disease, 200 mcg selenium for 8 weeks improved insulin sensitivity and reduced inflammation (decreased insulin, HOMA-IR, hs-CRP; increased QUICKI, TAC). In hypothyroid patients on thyroid hormone, HOMA-IR decreased and insulin sensitivity improved. Author recommends checking intake via Cronometer before supplementing, as excess selenium is harmful.
Source summary and thread relationship - @lowmegatron · 2026-03-19 original
Author cites a pilot study showing Brazil nut supplementation increased thyroid hormone in selenium-deficient hemodialysis patients; explains selenium's role in thyroid hormone conversion and autoimmune thyroid conditions; advises checking selenium intake before supplementing.
Source summary and thread relationship - @lowmegatron · 2026-03-21 original
Author cautions against altering template meanings when adding value. Shares embedded post by lowmegatron on iron reduction and cancer risk, citing Ray Peat quotations on iron, vitamin E, coffee, unsaturated fats, vitamin C and copper.
Source summary and thread relationship - @lowmegatron · 2026-03-23 original
Phlebotomy-induced reduction of excess iron in metabolic syndrome patients significantly decreased blood pressure, fasting blood sugar, and other cardiometabolic markers; author advises knowing iron status before making changes.
Source summary and thread relationship - @lowmegatron · 2026-03-25 own thread
The post text is only links. Its quoted post by lowmegatron lists claimed ways to address endotoxin, including cascara sagrada, minocycline, aspirin, cocoa, coffee, DHEA, ginger, glycine, sleep, naringenin, orange juice, pregnenolone, progesterone, probiotics, sugar, taurine, several vitamins, mushrooms and zinc, and notes PUFA-rich high-fat diets may raise endotoxin.
Source summary and thread relationship - @lowmegatron · 2026-04-11 original
Brief statement that potassium depletion causes glucose intolerance and impaired insulin secretion, and most people lack adequate intake. Appears to introduce embedded quoted post.
Source summary and thread relationship - @lowmegatron · 2026-04-12 original
Comprehensive explanation of selenium's role in thyroid hormone conversion and autoimmune thyroid disease. Covers mechanisms in acute stress, effects in Hashimoto's via RCT and case study, effects in Graves' disease and thyroid eye disease, synergy with myo-inositol, and recommended dosing.
Source summary and thread relationship - @lowmegatron · 2026-04-15 original
Bacterial endotoxin (LPS) lowers both TSH and thyroid hormones, creating misleading thyroid test results. Multiple dietary and supplemental compounds may reduce endotoxin burden or its effects.
Source summary and thread relationship - @lowmegatron · 2026-04-28 original
List of interventions reported to improve insulin sensitivity with supporting references; embedded quote on thyroid-insulin pathways in hypothyroidism.
Source summary and thread relationship - @lowmegatron · 2026-04-29 original
Nocturnal hypoglycemia triggers counterregulatory hormones (adrenaline, noradrenaline, cortisol, ACTH) that cause wakefulness, often around 3 AM. Multiple risk factors identified: hypothyroidism, high starch/protein before sleep, low carbohydrate intake, high stress. Recommended interventions include adequate daytime carbohydrates, sugar-based foods with protein/fat/minerals before bed.
Source summary and thread relationship - @lowmegatron · 2026-05-06 original
Author presents research on subclinical hypothyroidism, TSH involvement in insulin resistance via inflammation and TLR4 signaling, and a list of interventions that may improve insulin sensitivity including thyroid hormone correction, supplements, and lifestyle factors.
Source summary and thread relationship - @lowmegatron · 2026-05-06 original
Author attributes to Ray Peat a mechanism explaining poor body temperature response to thyroid medication: stress hormones shifting T4 metabolism to reverse T3, and emphasizes selenium sufficiency for T4-to-T3 conversion.
Source summary and thread relationship - @lowmegatron · 2026-05-14 original
lowmegatron compiles Ray Peat quotes saying that copper is crucial for hair and skin color and for oxygen use and energy, that excess iron can block copper absorption, that cytochrome oxidase is copper-dependent and is restored by red light, thyroid and progesterone, and that T3 increases copper absorption.
Source summary and thread relationship - @lowmegatron · 2026-05-16 original
Ray Peat explanation of thyroid hormone T3 role in carbon dioxide formation, cellular respiration, and bone formation; embedded quoted post details baking soda study on bone loss reduction via bicarbonate.
Source summary and thread relationship - @lowmegatron · 2026-05-24 original
Ray Peat quote on safety of tattoo ink; synchrotron study demonstrating migration of tattoo pigment nanoparticles from skin to lymph nodes and presence of toxic metals including chromium and nickel.
Source summary and thread relationship - @lowmegatron · 2026-05-26 original
Author lists sixteen factors that can impair thyroid hormone response: elevated free fatty acids, low total cholesterol, levothyroxine monotherapy, inappropriate T3 dosing, empty-stomach T3 administration, wrong T4:T3 ratio, TSH-only dosing, micronutrient insufficiencies (sodium, magnesium, calcium, retinol, zinc, selenium, vitamin D), high polyunsaturated fat intake, estrogen dominance, protein imbalance, and iron/iodine imbalance. Embedded post emphasizes carbohydrate's role in hepatic T3 production.
Source summary and thread relationship - @lowmegatron · 2026-06-01 original
Practical tips for lowering prolactin and serotonin through thyroid optimization, nutrient status, dietary fat composition, light exposure, supplements, and specific compounds; includes embedded quote on cyproheptadine mechanism for SSRI sexual dysfunction.
Source summary and thread relationship - @lowmegatron · 2026-06-03 original
Ray Peat quote on intestinal inflammation from infection and undigested starches causing endotoxin-driven insulin resistance; comprehensive list of dietary and supplement interventions claimed to reduce endotoxin and associated inflammation.
Source summary and thread relationship - @lowmegatron · 2026-06-03 original
CO2-enriched water bathing improves peripheral blood flow through direct CO2 effects and Bohr effect increasing oxygen delivery to tissues; historical use for cardiovascular disease; describes commercial products (CO2 bath tablets, immersion suits) without explicit sales promotion.
Source summary and thread relationship - @lowmegatron · 2026-06-04 original
PEA and luteolin supplement combined with olfactory training restored normal smell in 56% of COVID anosmia patients versus 10% placebo. Describes mechanism as anti-inflammatory/neuroprotective, addresses proper micronization, and explains olfactory training protocol.
Source summary and thread relationship - @lowmegatron · 2026-06-04 original
Storing water in copper pots overnight kills bacteria. Copper content remains within WHO permissible limits. Cited as promising method for microbial purification in developing countries.
Source summary and thread relationship - @lowmegatron · 2026-06-06 original
Sharing a post about selenium's role in thyroid hormone conversion and autoimmune thyroid conditions; notes Brazil nut supplementation study in hemodialysis patients showing thyroid hormone improvement, with caution about excess selenium.
Source summary and thread relationship - @lowmegatron · 2026-06-09 original
Iodine balance is critical in hypothyroidism; excessive iodine can cause or worsen thyroid dysfunction. Studies show iodine restriction normalizes TSH and increases free T4 in subclinical hypothyroidism. High intake defined as >1000 μg/day or urine iodine exceeding reference range (8.6–41.3 μmol/g creatinine). Antioxidants (selenium, vitamin C, E) reduce oxidative stress from excess iodine but do not eliminate risk. Some individuals tolerate high-iodine protocols; others develop hypothyroidism or hyperthyroidism rapidly (Wolff-Chaikoff effect, Jod-Basedow phenomenon).
Source summary and thread relationship - @lowmegatron · 2026-06-12 original
lowmegatron says selenium deficiency can cause curly hair and nail changes that reverse when selenium is corrected. The post cites two men in case reports, in the context of elemental diets or total parenteral nutrition, and notes that copper deficiency and other factors can cause similar changes.
Source summary and thread relationship - @1immortals1 · 2026-06-20 original
Shilajit, a mineral-dense resin from Himalayan rocks formed from compressed plant matter over centuries, contains 85+ minerals in bioavailable form and has been used in Ayurvedic medicine for 3,000 years. Contains fulvic acid for nutrient transport, increases mitochondrial CoQ10, shown to increase testosterone 23.5% in clinical study, improves sperm count and motility, reduces altitude fatigue, and enhances other supplement absorption.
Source summary and thread relationship - @1immortals1 · 2026-06-24 original
Water without electrolytes passes through the body; cells require minerals for absorption and retention. Electrolyte protocol recommended: 3,000-5,000 mg sodium daily, 3,500-4,700 mg potassium daily, 400-600 mg magnesium daily. Signs of electrolyte deficiency include headaches unresponsive to water, muscle cramps, afternoon brain fog, orthostatic dizziness, and unresolved fatigue. Fix: salt and lemon in water or proper electrolyte mix with 1,000+ mg sodium per serving.
Source summary and thread relationship - @lowmegatron · 2026-06-25 original
Brief quotation from Friedrich Miescher on carbon dioxide and oxygen supply, followed by claim that elevated CO2 increases oxygen release from hemoglobin; embedded quote references Ray Peat and Bud Weiss discussion on CO2 biology.
Source summary and thread relationship - @lowmegatron · 2026-06-25 original
lowmegatron quotes Ray Peat on graying hair. Peat says he has seen DHEA correct it quickly, that melanin-producing enzymes need copper, and that shellfish is a good source of copper with less iron. The quote also recommends low DHEA doses and warns that excess DHEA may convert to estrogen or testosterone in people deficient in progesterone, pregnenolone or thyroid.
Source summary and thread relationship - @1immortals1 · 2026-06-26 original
Beef liver is the most nutrient-dense food available, superior to supplements and superfoods. Contains preformed retinol, B12, copper, folate, CoQ10, and choline at high concentrations. Traditional cultures prioritized organ meats for nutritional density.
Source summary and thread relationship - @lowmegatron · 2026-06-29 original
Author presents Ray Peat quote on hypothyroidism causing sodium and glucose deficiency, followed by embedded lowmegatron post on stress hormone suppression of thyroid hormone conversion and lifestyle factors affecting cortisol and adrenaline.
Source summary and thread relationship - @lowmegatron · 2026-07-01 original
List of compounds and conditions that lower or elevate histamine; embedded post by lowmegatron reporting personal experience with PEA for histamine symptoms and citing clinical/veterinary/animal evidence for PEA in mast cell disorders.
Source summary and thread relationship - @lowmegatron · 2026-07-03 original
lowmegatron says stinging nettles are a source of serotonin and histamine. He quotes text that nettle sting fluid contains formic acid, leukotrienes, acetylcholine, histamine and serotonin, with estimated serotonin per sting. The quoted parent lists things he says lower or raise histamine.
Source summary and thread relationship - @jamesbondwisdom · 2026-07-04 original
The author claims iron deficiency and low ferritin cause hair loss in men but are rarely checked. He says some researchers suggest ferritin above 70 ng/mL is needed for hair growth, versus a lab 'normal' cutoff of about 20. He recommends asking for a ferritin test and, if below 70, considering iron bisglycinate with vitamin C, away from coffee and dairy.
Source summary and thread relationship - @1immortals1 · 2026-07-05 original
Author explains zinc's role in testosterone production and male health, discusses prevalence of deficiency due to modern diet and lifestyle factors, distinguishes bioavailable zinc forms, recommends dosing and duration, and warns against copper depletion from excessive intake.
Source summary and thread relationship - @1immortals1 · 2026-07-05 original
Author explains amino acid spiking in protein powders—addition of cheap amino acids like glycine, taurine, and creatine to inflate nitrogen-based protein measurements while reducing functional protein content. Provides detection methods via ingredient lists, leucine content verification, and third-party lab verification.
Source summary and thread relationship - @lowmegatron · 2026-07-05 own thread
lowmegatron quotes a passage claiming that vitamin D, zinc, anabolic and protein-related factors such as vitamin A, and a balanced calcium-phosphate ratio suppress aldosterone. It says the ratio is generally too high in calcium, and that calcium works with vitamin D to hold down aldosterone, which it calls the "major brittleizing hormone".
Source summary and thread relationship - @lowmegatron · 2026-07-06 original
Near-infrared light therapy reduces thyroid volume in Hashimoto's disease; combined with vitamin D (if serum <40 ng/mL) and 100 mcg oral selenium; 4x more patients reached normal thyroid volume; includes embedded Ray Peat quote about diet context.
Source summary and thread relationship - @lowmegatron · 2026-07-07 original
Selenomethionine supplementation (200 mcg daily) during and after pregnancy reduces thyroid inflammation, TPO antibodies, and postpartum thyroid dysfunction in women with elevated TPO antibodies. Direct quotation from published study provided with specific outcome percentages and lab guidance on plasma selenium adequacy ranges.
Source summary and thread relationship - @jamesbondwisdom · 2026-07-08 original
The author claims pumpkin seed oil, 400mg daily, raised hair count 40% vs 10% placebo in a 2014 double-blind trial, via 5-alpha reductase inhibition and androgen receptor effects, without affecting testosterone or sexual function. He also cites tocopherols, zinc and fatty acids, and suggests oral plus topical use, comparing with finasteride costs and side effects.
Source summary and thread relationship - @lowmegatron · 2026-07-10 original
Ray Peat quoted on nutrient needs during stress, including vitamins A, C, E, pantothenic acid, and minerals magnesium, calcium, potassium, zinc, and sodium for different stress stages. Embedded post by lowmegatron discusses thyroid hormone T3/T4 as anti-stress substances and their protective effect against stress-induced gastric ulcers in animal research.
Source summary and thread relationship - @lowmegatron · 2026-07-10 original
Author reports study findings on vitamin D supplementation reducing thyroid peroxidase antibodies in Hashimoto's patients. Embedded quoted post by lowmegatron discusses near-infrared light therapy combined with supplements reducing thyroid volume and improving function in Hashimoto's.
Source summary and thread relationship - @jamesbondwisdom · 2026-07-11 original
The author claims hair loss often originates in the gut through dysbiosis, leaky gut and endotoxin, reduced vitamin and iron absorption, and altered hormone metabolism. He advises avoiding processed foods and seed oils, eating fermented foods, taking probiotics and bone broth.
Source summary and thread relationship - @jamesbondwisdom · 2026-07-12 original
The author claims stacking a multi-mechanism protocol gives 3-5x better results than single treatments. The stack includes saw palmetto, pumpkin seed oil, no seed oils, omega-3, black seed oil, scalp massage, rosemary, weekly microneedling, zinc, biotin, vitamin D3, sleep, ashwagandha and less caffeine. He gives monthly costs of $40-60.
Source summary and thread relationship - @lowmegatron · 2026-07-13 original
Chromium picolinate at 1,000 mcg taken with levothyroxine reduces T4 absorption by ~17% over 6 hours in small study of 7 healthy volunteers. Mechanism is similar to ferric ion binding thyroxine causing malabsorption. Embedded quote discusses soy phytoestrogen interference with levothyroxine absorption and thyroid function.
Source summary and thread relationship - @jamesbondwisdom · 2026-07-14 original
The author claims iron deficiency, shown by low ferritin (below about 40), is an overlooked cause of hair loss and telogen effluvium, that standard blood tests miss it, and that topicals won't work without correcting it. He adds that caffeine reduces iron absorption and vitamin C increases it.
Source summary and thread relationship - @1immortals1 · 2026-07-14 original
Shilajit is a Himalayan resinous substance containing fulvic acid and 85+ minerals in ionic form; claimed to increase testosterone 20-23.5%, CoQ10 27%, improve energy through enhanced ATP production, provide adaptogenic stress modulation, and improve nutrient bioavailability. Recommended purified resin form at $30-40/jar.
Source summary and thread relationship - @lowmegatron · 2026-07-14 original
Low serum magnesium is associated with 3-4x increased likelihood of hypothyroidism, Hashimoto's disease, and thyroglobulin antibody positivity. Mechanisms involve immune dysregulation, cellular oxidative stress, energy metabolism, and mitochondrial function. Relationship may be bidirectional. Magnesium supplementation can improve thyroid function.
Source summary and thread relationship - @jamesbondwisdom · 2026-07-15 original
The author claims most people taking biotin for hair are wasting money since deficiency is rare, and that studies showing benefit involved deficient people. He warns that biotin interferes with thyroid and other lab tests and suggests testing iron, zinc, vitamin D and thyroid first. He also claims rosemary oil matches minoxidil.
Source summary and thread relationship - @lowmegatron · 2026-07-15 original
Author clarifies that carbonation in magnesium bicarbonate water is only needed to form the compound; water can be consumed flat. Embedded post from lowmegatron describes magnesium bicarbonate water preparation method and rationale.
Source summary and thread relationship - @1immortals1 · 2026-07-15 original
Iodine insufficiency in 74% of population causes metabolic slowdown, fatigue, brain fog, and weight gain by preventing thyroid hormone production. Explains iodine structure in T3/T4, dietary sources and modern deficiency, brain and tissue effects, and recommends 150-500 mcg daily with selenium.
Source summary and thread relationship - @lowmegatron · 2026-07-16 original
Oranges reduce age-related macular degeneration risk; naringin and naringenin in peel inhibit lipid peroxidation and chelate iron, with marmalade providing concentrated protective compounds plus anti-stress sugar.
Source summary and thread relationship - @1immortals1 · 2026-07-18 original
Author claims raw beef liver is a complete multivitamin replacement, the most nutrient-dense food by any measure, containing exceptionally high levels of B12, vitamin A (preformed retinol), CoQ10, and bioavailable minerals; recommends 100g twice weekly with dosing options and pricing.
Source summary and thread relationship - @jamesbondwisdom · 2026-07-19 original
jamesbondwisdom proposes a multi-mechanism hair-regrowth protocol. It includes saw palmetto, rosemary oil, green tea, seed-oil removal, omega-3, ketoconazole shampoo, scalp massage, microneedling, ferritin, vitamin D and zinc, bone broth, sleep and stress management. He claims it is cheaper than finasteride and has no systemic side effects.
Source summary and thread relationship - @lowmegatron · 2026-07-24 original
Ray Peat on thyroid hormone T4-to-T3 conversion: requires glucose, selenium, adequate protein, and specific nutrient ratios; discusses mineral balance, estrogen interference, and optimal dosing strategies for thyroid replacement therapy including desiccated thyroid and synthetic combinations.
Source summary and thread relationship - @jamesbondwisdom · 2026-07-25 original
jamesbondwisdom claims 60% of men with hair loss have untested zinc deficiency, that zinc inhibits 5-alpha-reductase, and that coffee and phytates impair absorption. He advises testing serum zinc (above 80 mcg/dL for hair) and suggests 30mg daily of zinc picolinate or other well-absorbed forms.
Source summary and thread relationship - @1immortals1 · 2026-07-25 original
Quercetin, a flavonoid from apples and onions, selectively destroys senescent cells ('zombie cells') that accumulate with age and drive aging through inflammatory SASP secretion. Multiple mechanisms described including senolytic activity, anti-inflammatory effects, antioxidant activity, and zinc ionophore activity; dosing recommendations for supplementation.
Source summary and thread relationship - @lowmegatron · 2026-07-29 original
Three-month randomized controlled trial in 70 women with Hashimoto's antibodies: selenium supplementation (200 mcg sodium selenite daily) achieved 25% remission of antibodies vs. 6% placebo; TPO antibodies decreased 34% vs. 12% placebo; thyroid structure normalized in responders.
Source summary and thread relationship - @lowmegatron · 2026-07-30 original
Higher serum selenium in older adults associated with higher T3, lower TSH, and lower T4, indicating improved thyroid hormone conversion and function. Study concludes reduced T4-to-T3 peripheral conversion related to impaired selenium status in elderly. Thyroid hormone conversion enzymes require selenium.
Source summary and thread relationship - @lowmegatron · 2026-07-30 original
Author lists interventions shown to lower thyroid antibodies in autoimmune thyroiditis, citing multiple peer-reviewed studies. Cautions that selenium and vitamin D optimization requires measurement, not blind supplementation.
Source summary and thread relationship - @jamesbondwisdom · 2026-08-05 original
The author claims hair loss may originate in the gut through dysbiosis, LPS leakage and inflammation. He cites iron absorption, biotin production, antibiotics, fermented foods and 30-40g of fiber, and says topicals fail if gut inflammation drives the loss.
Source summary and thread relationship - @jamesbondwisdom · 2026-08-07 original
The author claims a 76-man trial found 400mg of pumpkin seed oil daily raised hair count by 40% in 24 weeks vs 10% for placebo, with no side effects. He attributes this to 5-alpha reductase inhibition and suggests stacking with rosemary oil.
Source summary and thread relationship - @lowmegatron · 2026-08-07 original
Bulleted list of dietary and lifestyle interventions for optimizing thyroid hormone conversion, including carbohydrate intake, stress management, micronutrient adequacy, avoiding mold/fluoride, and T3/T4 hormone balance considerations.
Source summary and thread relationship - @lowmegatron · 2026-08-08 original
Ray Peat quoted explaining that stress (cortisol and adrenaline) can shift T4 metabolism toward reverse T3 formation; emphasizes selenium as crucial nutrient for T4 to T3 conversion across all tissues requiring seafood intake (~weekly).
Source summary and thread relationship - @lowmegatron · 2026-08-10 original
Author reports multiple anecdotes linking plantar fasciitis to low thyroid hormone; NDT treatment and increased carbohydrate intake resolved foot pain; embedded study shows higher TSH and lower T3/T4 in plantar fasciitis patients.
Source summary and thread relationship - @lowmegatron · 2026-08-10 original
Selenium concentration is highest in the thyroid and deficiency is associated with hypothyroidism, subclinical hypothyroidism, Hashimoto's, Graves' disease, and thyroid cancer. Embedded quote attributes to lowmegatron that selenium is required for thyroid hormone conversion and calms autoimmune thyroid processes.
Source summary and thread relationship - @1immortals1 · 2026-08-12 original
Salt restriction causes more harm than benefit. Table salt is chemically processed and mineral-depleted; mineral-rich salts (sea salt, Redmond Real Salt, Himalayan) contain trace minerals essential for adrenal function, muscle contraction, neuron firing, stomach acid production, and hydration. The sodium-health relationship follows a J-curve; low intake is as dangerous as high intake.
Source summary and thread relationship - @lowmegatron · 2026-08-12 original
Selenium is essential for tissue-level thyroid hormone T3 production. Consuming shellfish, seafood, halibut, cod, or sole provides sufficient selenium to maintain active tissue thyroid hormone supply.
Source summary and thread relationship - @lowmegatron · 2026-08-12 own thread
Quoting Ray Peat, the post claims one seafood meal per week supplies enough selenium for tissues to form T3. It says that without selenium, tissues cannot make the T3 they need even if circulating T4 is adequate, because selenium is required for deiodinases.
Source summary and thread relationship - @lowmegatron · 2026-08-12 own thread
Quoting (apparently Ray Peat; the attribution is not stated in this post), the post claims selenium is needed to activate the thyroid, that other B vitamins and nutrients are needed too, that low thyroid and low selenium are the most common problems, and that glucose is needed to use selenium for thyroid activation.
Source summary and thread relationship - @lowmegatron · 2026-08-12 own thread
Quotes Ray Peat as saying that lacking selenium or vitamin D can leave T4 unconverted so it accumulates and interferes with T3, becoming antithyroid, and that he thinks 100 micrograms of selenium is a safe supplement. The quoted context is the author's own claim that selenium concentration is highest in the thyroid and that deficiency is associated with several thyroid conditions.
Source summary and thread relationship - @jamesbondwisdom · 2026-08-16 original
The author claims iron or ferritin deficiency, even without anemia, is a common hidden cause of hair shedding and telogen effluvium. He says ferritin should be tested and kept around 70-80 ng/mL, discusses absorption factors, and suggests iron bisglycinate 25-50 mg daily with vitamin C (his suggestion, not verified).
Source summary and thread relationship - @lowmegatron · 2026-08-17 original
Author lists interventions claimed to decrease chronically elevated cortisol, including light exposure, dietary fats, micronutrients, supplements, and lifestyle factors. Quoted source discusses mold-induced stress lowering thyroid hormone T3 conversion and successful T3 supplementation in four patients previously unresponsive to levothyroxine.
Source summary and thread relationship - @lowmegatron · 2026-08-17 original
Author claims zinc supplementation improves insulin resistance, inflammation, and oxidative stress in type 2 diabetes, citing systematic review. Embedded quote from lowmegatron discusses high cortisol causally increasing diabetes and obesity risk.
Source summary and thread relationship - @lowmegatron · 2026-08-18 original
Autoimmune patients have lower zinc levels. Zinc deficiency causes thymic atrophy, impairing self-tolerance. Animal studies show zinc supplementation increases regulatory T cells and reduces Th17 cells in experimental autoimmune encephalomyelitis (mouse model of MS), suggesting zinc may induce immune tolerance in autoimmunity without immunosuppression.
Source summary and thread relationship - @jamesbondwisdom · 2026-08-23 original
The author argues that some hair loss reflects nutritional or thyroid problems rather than genetics, and suggests testing ferritin, vitamin D, TSH and zinc. He says DHT loss follows a pattern (temples, crown) while deficiency loss is diffuse, and tells readers to run the panel before buying topicals.
Source summary and thread relationship - @jamesbondwisdom · 2026-08-30 original
The author claims biotin supplements are a $3 billion scam, because deficiency is rare and there is no RCT showing benefit in non-deficient people. They say the company-cited studies involve deficient patients, and that money is better spent on rosemary oil, ketoconazole shampoo and a derma roller, plus testing iron, zinc and vitamin D.
Source summary and thread relationship - @lowmegatron · 2026-09-01 original
Thyroid hormones regulate ferritin synthesis independent of iron stores; thyroid status affects multiple iron-related biomarkers including ferritin, hemoglobin, transferrin, and TIBC. Reticulocyte hemoglobin may help distinguish thyroid-driven ferritin changes from iron deficiency.
Source summary and thread relationship - @lowmegatron · 2026-09-01 original
Iron destroys vitamin E in animal feed and caused female rat infertility; wheat germ oil (vitamin E source) reversed iron-induced sterility. Author attributes Ray Peat quote and includes embedded discussion of policosanols and crude vitamin E historical research.
Source summary and thread relationship - @lowmegatron · 2026-09-01 original
Anemia has multiple causes; hemolytic anemia from vitamin E deficiency is common in premature infants and responsive to vitamin E treatment. Iron supplementation alone may worsen hemolytic anemia if vitamin E deficiency is present because iron destroys vitamin E.
Source summary and thread relationship - @lowmegatron · 2026-09-01 original
Commercial laboratory animal diets in 1940s caused sudden neurogenic disease (tremors, forced movements, head retraction, weakness) in chicks due to iron salts destroying added vitamin E. Vitamin E supplementation (0.2mg alpha-tocopherol daily) prevented disease.
Source summary and thread relationship - @lowmegatron · 2026-09-02 original
Thyroid hormone increases ferritin by releasing the brake on ferritin synthesis; ferritin falls when thyroid hormone drops.
Source summary and thread relationship - @1immortals1 · 2026-09-02 original
Senescent (zombie) cells accumulate with age, secrete inflammatory signals, and contribute to aging. Quercetin, a plant flavonoid, acts as a senolytic by eliminating senescent cells. Cites Mayo Clinic research calling it first true senolytic available without prescription. Recommends 500–1000 mg quercetin daily, optionally with bromelain and zinc for enhanced absorption and ionophore effect.
Source summary and thread relationship - @lowmegatron · 2026-09-03 original
Milk reduces lead absorption by up to 80%, primarily through calcium content, potentially reducing bioavailability of ingested lead particularly in individuals with low dietary calcium.
Source summary and thread relationship - @lowmegatron · 2026-09-03 original
List of interventions for high histamine including thyroid correction, DAO enzyme, micronized PEA, progesterone, B vitamins, magnesium, L-theanine, copper, vitamins C and E, low PUFA diet, and hypoglycemia avoidance; author notes context-dependent efficacy. Embedded quote details personal PEA experimentation with symptom reduction and extensive research on PEA mechanisms in mast cell modulation.
Source summary and thread relationship - @1immortals1 · 2026-09-05 original
Zinc is required for 300+ enzymatic reactions including testosterone production, immune function, DNA synthesis, wound healing, and neurotransmitter regulation; ~2 billion people globally are zinc deficient with no body storage reserves. RDA 11 mg prevents deficiency; functional practitioners recommend 15-30 mg for optimization in athletes and plant-based dieters.
Source summary and thread relationship - @lowmegatron · 2026-09-08 original
Coffee drinkers have lower TSH and much lower risk of subclinical hypothyroidism; embedded post attributes extensive caffeine and coffee health benefits to Ray Peat, including thyroid protection, liver protection, cancer prevention, and cognitive effects.
Source summary and thread relationship - @jamesbondwisdom · 2026-09-11 original
jamesbondwisdom claims zinc is the only mineral that inhibits 5-alpha reductase, supports keratin synthesis and maintains sebaceous glands. The post says zinc deficiency causes hair loss, cites an alopecia areata study (66.7% with lower serum zinc), and compares zinc with finasteride and shampoo costs. It also says each ejaculation depletes about 5mg of zinc. It recommends 15-30mg of zinc picolinate or bisglycinate with food, and cautions about copper above 40mg.
Source summary and thread relationship - @lowmegatron · 2026-09-15 original
General health optimization guidance recommending 'basic' nutrient coverage before exotic interventions. Lists common deficient micronutrients: magnesium, potassium, selenium, vitamins D, C, E, K1/2, thiamine. Advises testing and dietary sources before supplementation. Cites foundational lifestyle: sunlight, sleep, walking. Embedded quote discusses interventions that lower thyroid antibodies.
Source summary and thread relationship - @1immortals1 · 2026-09-16 original
Apple cider vinegar (ACV) reduces post-meal blood glucose by 34% and improves insulin sensitivity by 19% according to an Arizona State University study. Mechanism is acetic acid inhibiting alpha-amylase enzyme, slowing carbohydrate digestion. Author provides dosing recommendations and product brand suggestion (Bragg's).
Source summary and thread relationship - @lowmegatron · 2026-09-16 original
Ray Peat recommended oysters for hormonal health due to zinc and selenium content. Zinc replenishment normalizes T3 thyroid hormone and lowers reverse T3 in zinc-deficient individuals. Selenium supports thyroid hormone conversion and reduces thyroid antibodies. Some people find thyroid hormones work better when incorporating oysters. Study citation provided on zinc role in thyroid metabolism.
Source summary and thread relationship - @1immortals1 · 2026-09-17 original
Chromium deficiency drives insulin resistance, sugar cravings, and fat accumulation through impaired insulin receptor binding; mechanism via chromodulin complex; supplementation with chromium picolinate recommended at 200-500 mcg daily.
Source summary and thread relationship - @lowmegatron · 2026-09-17 original
Multiple overlooked factors contribute to insulin resistance beyond diet and exercise, including carrageenan, thyroid hormones, minerals, stress, endotoxin, light exposure, vitamins, sleep, and movement.
Source summary and thread relationship - @1immortals1 · 2026-09-19 original
The author claims supplementing zinc without copper depletes copper and can cause deficiency (anemia, connective tissue, neurological problems, early graying), and proposes copper supplementation at roughly a 15:1 zinc:copper ratio. Mentions zinc's benefit for testosterone only in passing.
Source summary and thread relationship - @1immortals1 · 2026-09-20 original
Fulvic acid, an organic compound from ancient soil microbial decomposition, chelates minerals and increases absorption by 200-500%; contains 70+ trace minerals; acts as antioxidant and heavy-metal chelator; improves gut barrier; recommendation to start 1/4 teaspoon daily, increase to 1/2 teaspoon over 2 weeks; product recommendations at $20 for 3 months.
Source summary and thread relationship - @jamesbondwisdom · 2026-09-24 original
The author claims jojoba oil is a liquid wax ester resembling human sebum. It is said to dissolve sebum plugs, regulate oil production, deliver nutrients to the follicle, be non-comedogenic, and provide SPF 4 to 6. The post gives usage directions and price comparisons against scalp detox products.
Source summary and thread relationship - @1immortals1 · 2026-09-25 original
Piperine from black pepper increases bioavailability of most supplements by 30-2000% by inhibiting hepatic cytochrome P450 enzymes (CYP3A4); dramatically increases curcumin absorption from 1% to 20%; effect lasts 1-2 hours post-ingestion.
Source summary and thread relationship - @jamesbondwisdom · 2026-09-25 original
The author claims curry leaves, eaten or applied as an infused oil, reverse hair loss and premature graying. Claimed mechanisms: mahanimbine activating Wnt signaling in follicle stem cells, plus beta-carotene, iron and antioxidants. The post gives a daily dose, a topical recipe, timelines, and low cost.
Source summary and thread relationship