Fasting, Caloric Restriction and Ketosis
78 associated posts. These are attributed summaries; original text remains at the linked X post and in the local archive.
- @lowmegatron · 2025-10-13 original
The author asks how Ray Peat would address insulin resistance and early type 2 diabetes, then shares a Peat excerpt. Peat claims chronic stress and estrogen raise free fatty acids, which interfere with glucose use, and that lowering stress and estrogen improves insulin sensitivity and glucose-to-CO2 conversion rather than lactic acid.
Source summary and thread relationship - @lowmegatron · 2025-10-14 own thread gap
lowmegatron lists what he calls common causes of stress: fasting, poor sleep, undereating, over-exercising, psychological stress, and low carbohydrate intake. He says it is often a combination, and that many people pair malnutrition with over-exercising.
Source summary and thread relationship - @lowmegatron · 2025-10-20 original
The author states that sleep restriction reduces fat loss and increases lean tissue loss during caloric restriction. They quote a study (PMID 20921542) and add that stress generally downregulates metabolism, wastes muscle and promotes fat storage. The embedded quoted post from lowmegatron lists common causes of stress.
Source summary and thread relationship - @lowmegatron · 2025-10-27 original
The author says that six years after The Biggest Loser, participants' resting metabolic rate was 27% lower. The author argues that extreme dieting and exercise stress lower resting metabolic rate (metabolic adaptation), that chasing lower energy intake or fasting harms health, and that energy is essential for health. The embedded quoted post is an anecdote from TElizabethPhD about intermittent fasting stopping working and eating constantly after following Ray Peat's work.
Source summary and thread relationship - @lowmegatron · 2025-10-28 original
The author says a 15-day fasting study showed T3 falling 34% and reverse T3 doubling while TSH and T4 stayed unchanged. They argue that stress lowers T3 even when common labs look fine. The post quotes study excerpts on impaired T4-to-T3 conversion and reduced rT3 clearance, and notes that Angus Barbieri died aged 51. The embedded post, by lowmegatron, says metabolic rate drops after extreme dieting.
Source summary and thread relationship - @lowmegatron · 2025-10-29 own thread
lowmegatron claims that cortisol, glucagon and adrenaline inhibit T4-to-T3 conversion, lowering T3 and raising reverse T3 in a vicious cycle. He lists common, easily corrected causes of high cortisol and adrenaline (poor sleep, too little carbohydrate, sodium, potassium, magnesium or calcium, fasting, chronic caloric restriction, noise, shallow breathing, black coffee on an empty stomach, constant stimulation). He suggests acerola vitamin C, L-theanine and glycine may help.
Source summary and thread relationship - @lowmegatron · 2025-10-29 own thread
lowmegatron claims the thyroid adjusts to energy availability, so undereating or chronic overexertion reduces thyroid hormone production, conversion or tissue sensitivity and lowers metabolic rate. He warns against combining fasting with intense exercise. He recommends muscle-focused exercise and suggests mild, careful caloric restriction balanced with periods of adequate intake.
Source summary and thread relationship - @lowmegatron · 2025-11-02 original
The post quotes Ray Peat saying adequate fiber and regular bowel function help prevent estrogen build-up that inhibits the thyroid, and that B vitamin or protein deficiency impairs liver estrogen excretion. A parenthetical explains reabsorption of bile-excreted estrogen. The embedded earlier post from the same handle says estrogen can turn the thyroid off.
Source summary and thread relationship - @lowmegatron · 2025-11-07 original
The author says fasting and high cortisol lower thyroid hormone and suppress TSH, and that common thyroid tests can be misleading under stress because a lower TSH is usually read as higher thyroid hormone. The quoted study text says mild cortisol elevations may mediate fasting-induced changes in TSH and thyroid hormone. The embedded lowmegatron post describes a 15-day fasting study with T3 down 34%, reverse T3 doubled and TSH/T4 unchanged.
Source summary and thread relationship - @lowmegatron · 2025-11-09 original
The author states that cortisol, adrenaline and glucagon inhibit thyroid hormone conversion, and lists common causes: chronic caloric restriction, low carbohydrate, poor sleep, low magnesium/potassium/calcium/sodium, and fasting. The quoted post (lowmegatron) cites Ray Peat saying stress can block T4-to-T3 conversion.
Source summary and thread relationship - @lowmegatron · 2025-11-14 original
The author claims 3.5 hours of exercise-bike riding alters thyroid hormone metabolism in a way similar to early or acute starvation, and that sugar minimizes the problem. A quoted passage reports rT3, T3 and T4 changes with exercise, and blunted rT3 changes when glucose was infused.
Source summary and thread relationship - @lowmegatron · 2025-11-16 original
Author claims fructose limits muscle wasting and thyroid hormone decline during fasting or dieting. They cite a 10-day fast in obese people where fructose infusion reduced nitrogen excretion and blunted hormone and metabolic changes. The embedded lowmegatron post lists factors said to inhibit thyroid hormone conversion.
Source summary and thread relationship - @lowmegatron · 2025-11-17 original
The author states that fructose is made in the human brain under normal conditions. They quote a passage saying MRS studies show cerebrospinal fluid fructose about 20-fold higher than blood, and that its precise roles remain under investigation. The embedded post by lowmegatron claims fructose infusion during a 10-day fast in obese people blunted fasting-induced hormonal and metabolic changes and spared protein.
Source summary and thread relationship - @lowmegatron · 2025-11-19 original
The author claims a little sugar lowers stress hormones, citing a rat study in which sucrose or saccharin drinking dampened HPA-axis stress responses. An embedded post says fasting and high cortisol lower thyroid hormone and suppress TSH, so thyroid tests can mislead under stress.
Source summary and thread relationship - @lowmegatron · 2025-11-27 original
The author says breakfast lowers stress and that skipping it disrupts metabolism. The author quotes a study on skipping breakfast, higher post-meal glucose, lower iGLP-1 and impaired insulin response in type 2 diabetes. The embedded quoted post (lowmegatron) claims coffee reduces fatty acid synthase and lipogenic enzymes, linking FASN to cancer.
Source summary and thread relationship - @lowmegatron · 2025-11-29 original
The author says all thyroid blood tests can be misleading and TSH is the worst. They support this with a Ray Peat quote that stress hormones lower TSH, so stressed, tired people can have very low TSH. They add an unnamed quoted sentence that short-term fasting and high-dose glucocorticoids suppress serum TSH in healthy subjects. The embedded lowmegatron post says stress lowers TSH, making it an unreliable marker of thyroid hormone activity.
Source summary and thread relationship - @lowmegatron · 2025-12-05 original
Author says increasing fruit fructose led to 50% greater weight loss in a six-week low-calorie diet trial. Author also says fructose limits muscle wasting and thyroid hormone depletion from dieting, citing an IV fructose protein-sparing study. The embedded lowmegatron post describes fructose infusion during a 10-day fast in obese people.
Source summary and thread relationship - @lowmegatron · 2025-12-08 original
The post claims 'eat less, move more' lowers T3 and raises reverse T3, citing Army Ranger training data. It says TSH can miss low tissue T3. The embedded lowmegatron post quotes Ray Peat that stress hormones lower thyroid conversion and TSH alone is inadequate.
Source summary and thread relationship - @lowmegatron · 2025-12-09 original
The post combines a Ray Peat quote on fruit juice/Coca-Cola with excerpts on intranasal CO2, orange juice, hypoglycemia, fasting and caffeine in migraine. It states caffeine seems to worsen migraine in a minority. The embedded lowmegatron post links stress, free fatty acids, linoleic acid and serotonin to migraine.
Source summary and thread relationship - @lowmegatron · 2025-12-12 original
Author states that low-calorie dieting increases cortisol and lists harms of high cortisol. They quote a paper saying 1200 kcal restriction increased cortisol output and perceived stress, and that clinicians may need to rethink recommending dieting.
Source summary and thread relationship - @lowmegatron · 2025-12-12 original
Author comments 'Jeff was born for this' while sharing lowmegatron's post on low-calorie dieting and cortisol. The comment is context-dependent, and no explicit support for the quoted claims is given.
Source summary and thread relationship - @lowmegatron · 2025-12-14 original
The author says caloric restriction, fasting and low-carb diets reduce thyroid hormone conversion, favoring reverse T3 over T3, and advises eating regularly, enough, and eating carbs. The embedded quoted post says low-calorie dieting increases cortisol, with a list of harms and study excerpts.
Source summary and thread relationship - @lowmegatron · 2025-12-19 original
The post shares a Ray Peat quote saying regular sleep timing, about six to nine hours a night, is protective and anti-stress, and that prolonged starvation or fasting can shrink the brain. The quoted lowmegatron post links hypothyroidism to reduced deep sleep, citing a 1967 study of 7 hypothyroid patients that reported fewer stage 3 and 4 sleep minutes, with some improvement after desiccated thyroid.
Source summary and thread relationship - @lowmegatron · 2025-12-28 original
The post shares Ray Peat interview excerpts claiming cooked potato juice or soup can relieve insomnia and help people who cannot digest protein. It presents ketoacid equivalents in potato protein as absorbing ammonia. The author adds that ammonia buildup is neurotoxic and causes insomnia, which is why Peat suggested potato juice.
Source summary and thread relationship - @lowmegatron · 2025-12-30 original
Author argues that people with anorexia have low T3 that improves with weight gain, that TSH is unreliable under stress, and that caloric restriction, fasting and exercise may suppress T3 and metabolic rate. Author suggests chronic repeated fasting likely harms long-term thyroid status. The embedded post (lowmegatron) says stress also lowers TSH, making it an unreliable marker.
Source summary and thread relationship - @lowmegatron · 2025-12-30 original
Author claims fasting and caloric restriction lower metabolism and thyroid hormone set points, often needing T3 to reset the famine response. A long quote from a paper on TSH and weight-loss hypothyroidism says TSH suppression during thyroid hormone treatment is expected. The embedded post (lowmegatron) claims carbohydrate deprivation cut T3 by 25%.
Source summary and thread relationship - @lowmegatron · 2026-01-09 original
Fasting increases gut serotonin which slows metabolic rate. Body limits non-essential functions during insufficient nutrition via higher serotonin, free fatty acids, and lower thyroid hormone. Embedded post from lowmegatron on undereating causing fat gain via adaptive metabolic reduction in athletes.
Source summary and thread relationship - @lowmegatron · 2026-01-13 original
Caloric restriction lowers T3 via decreased T4-to-T3 conversion (not thyroid output); T4 is shunted to reverse T3 instead; TSH suppression during treatment reflects normal adaptation, not overmedication; standard thyroid testing fails to detect this metabolic suppression.
Source summary and thread relationship - @lowmegatron · 2026-01-13 original
Comprehensive compilation of potential health benefits of aspirin across multiple mechanisms: antibiofilm activity, cancer prevention, dopamine pathway stimulation, immune regulation, metabolic effects, cardiovascular protection, liver health, bone regeneration, and metabolic flexibility. No commercial promotion included.
Source summary and thread relationship - @lowmegatron · 2026-01-13 original
Exercise in caloric deficit lowers T3 thyroid hormone and causes amenorrhea; increasing calories can help. CICO model ignores thyroid hormone and metabolic rate adaptation. Cortisol from exercise and low-calorie stress lowers TSH, which doctors may miss. Study tested effects but not TSH.
Source summary and thread relationship - @lowmegatron · 2026-01-14 own thread
lowmegatron corrects a typo in his earlier post on dieting and thyroid hormones: the phrase 'because TSH increases during stress' should read 'TSH decreases'.
Source summary and thread relationship - @lowmegatron · 2026-01-22 original
Replying via quote to a user asking why they are not losing weight on one meal a day and 10k+ steps, the author claims this signals food scarcity. The author says the body then lowers metabolic rate and stores fat by lowering T3 and raising serotonin.
Source summary and thread relationship - @lowmegatron · 2026-01-23 original
Thyroid hormone levels correlate with caloric intake; caloric restriction reduces T3 conversion and suppresses thyroid hormone despite normal or low TSH, compromising weight loss effectiveness.
Source summary and thread relationship - @lowmegatron · 2026-01-24 original
Fasting, low-calorie diets, and low-carbohydrate intake send famine signals reducing thyroid hormone T3 conversion and tissue uptake; increased free fatty acids from dietary stress block thyroid hormone activity.
Source summary and thread relationship - @lowmegatron · 2026-01-27 original
The author claims dieting and fasting can reset the metabolic set-point downward in some people by lowering T3 and raising reverse T3, hindering weight loss. He says thyroid levels may need correcting and that TSH is a useless marker for dosing, since thyroid replacement during weight loss suppresses TSH. Quotes are from Rowsemitt and Najarian.
Source summary and thread relationship - @lowmegatron · 2026-01-31 original
Protein-modified fasts lower potassium and insulin, impairing glucose utilization; potassium supplementation restores insulin levels and glucose utilization in fasting and prediabetes.
Source summary and thread relationship - @lowmegatron · 2026-02-04 own thread
lowmegatron claims that cortisol, glucagon and adrenaline inhibit thyroid hormone conversion, lowering T3 and raising reverse T3. He lists factors he says commonly raise cortisol and adrenaline, including poor sleep, too few carbohydrates, sodium, potassium, magnesium or calcium, fasting, chronic caloric restriction, noise, shallow breathing, black coffee on an empty stomach and constant stimulation. He suggests acerola vitamin C, L-theanine and glycine as possibly helpful.
Source summary and thread relationship - @lowmegatron · 2026-02-04 own thread
lowmegatron claims that the thyroid adjusts to energy availability, so undereating or excessive exercise can lower thyroid hormone production and metabolic rate. He warns against combining fasting with intense exercise, recommends muscle-focused exercise, and suggests mild, careful caloric restriction balanced with adequate intake periods.
Source summary and thread relationship - @lowmegatron · 2026-02-05 original
Repost of lowmegatron's analysis of thyroid hormone changes during fasting/dieting, citing a study showing decreased T3/free T3 and increased rT3, with quotes from Rowsemitt & Najarian on metabolic adaptation and TSH management during weight loss.
Source summary and thread relationship - @lowmegatron · 2026-02-09 original
Author explains that elevated free fatty acids block T4 uptake in the liver, reducing active T3 production, and identifies conditions elevating free fatty acids (fasting, restriction, stress, cold, low-carb diets, sleep deprivation, infection). Insulin reduces free fatty acids. Includes quoted study text on ATP depletion and circulating inhibitors.
Source summary and thread relationship - @lowmegatron · 2026-02-20 original
Explanation that liver carbohydrate availability regulates T4-to-T3 conversion and metabolic rate; glucose is essential for T3 production; Ray Peat quote on hypothyroid temperature and pulse response to carbohydrate feeding; study citation on dietary carbohydrate and T3 production; embedded quote on thyroid dysfunction during ketogenic diet in epilepsy patients.
Source summary and thread relationship - @lowmegatron · 2026-02-23 original
Brief statement that T3 increases non-exercise activity thermogenesis (NEAT); embedded quote from BerbarianWizard describing fat loss stall at very low calories resuming after higher-carbohydrate refeeds.
Source summary and thread relationship - @lowmegatron · 2026-03-21 original
Author argues that T4-only thyroid replacement does not replicate natural thyroid gland function due to T4:T3 ratio imbalance and that the system requires some T3; lists factors impairing T4-to-T3 conversion.
Source summary and thread relationship - @lowmegatron · 2026-04-05 original
Author expresses observation of 'increased autophagy' in response to quoted Minnesota Starvation Experiment results showing severe metabolic and physiological decline.
Source summary and thread relationship - @lowmegatron · 2026-04-13 original
Explains how weight loss from extreme caloric restriction reduces active thyroid hormone T3 and increases muscle energy efficiency, lowering resting metabolic rate. Discusses adaptive thermogenesis mechanisms and evidence that T3 repletion reverses these adaptations. Presents three takeaways on metabolic-protective weight loss approaches.
Source summary and thread relationship - @lowmegatron · 2026-04-14 original
Crash dieting reduces active thyroid hormone T3, increases muscle energy efficiency, and decreases resting metabolic rate; T3 supplementation reverses these metabolic adaptations.
Source summary and thread relationship - @lowmegatron · 2026-04-14 original
Multiple expert and research sources explain that blood sugar fasting triggers liver suppression of T3 thyroid hormone to preserve tissue, and that dietary carbohydrate is essential for T3 production; thyroid hormone supplementation corrects metabolic downregulation in weight loss without accelerating metabolism above normal.
Source summary and thread relationship - @lowmegatron · 2026-04-20 original
Higher metabolic rate correlates with longevity in mice and between-individual variation. Author presents evidence refuting 'wear-and-tear' and 'rate of living' theories, arguing intensified mitochondrial respiration decreases damage and supports longer lifespan. Includes Ray Peat commentary on metabolic intensity and caloric restriction.
Source summary and thread relationship - @lowmegatron · 2026-04-23 original
Author reports 5 people reducing hypothyroid symptoms and increasing T3 via increased calories/carbohydrates; Ray Peat on T4-to-T3 conversion via diet; multiple studies on carbohydrate restriction's effects on thyroid hormones (T3, rT3, T4).
Source summary and thread relationship - @lowmegatron · 2026-05-04 own thread
lowmegatron lists claimed common causes of stress: fasting, poor sleep, undereating, over-exercising, psychological stress and low carbohydrate intake. He says it is often a combination of causes and that many people pair malnutrition with over-exercising.
Source summary and thread relationship - @lowmegatron · 2026-05-06 original
Author claims fasting until noon worsens metabolic outcomes in type 2 diabetes by raising stress hormones and free fatty acids, and cites a randomized trial showing breakfast consumption reduces postprandial hyperglycemia.
Source summary and thread relationship - @lowmegatron · 2026-06-01 own thread
lowmegatron claims polyunsaturated fatty acids increase gut serotonin in hibernating animals, slowing metabolic rate and favoring fat accumulation. He adds that fasting also increases gut serotonin to slow metabolism and prevent starvation.
Source summary and thread relationship - @lowmegatron · 2026-06-02 original
Ray Peat quote on cortisone/cortisol damaging pancreas and chronic stress from low blood sugar in diabetes; embedded post by lowmegatron synthesizes cortisol studies linking elevated cortisol to blood glucose, glucocorticoid receptor blocking effects, and dietary/lifestyle factors affecting cortisol and glucose metabolism.
Source summary and thread relationship - @lowmegatron · 2026-06-02 original
Low-fat, high-carbohydrate ad libitum diets produce weight loss and fat loss in multiple studies; embedded post from lowmegatron explains carbohydrates are needed for thyroid hormone T3 conversion with Ray Peat quote on metabolic regulation by glucose.
Source summary and thread relationship - @lowmegatron · 2026-06-10 original
lowmegatron claims that fasting causes hair loss by increasing fat burning. He cites rodent research in which fasting raises stress hormones and lipolysis, and free fatty acids cause hair follicle stem cell apoptosis, which topical vitamin E prevented in mice. He also cites human follicle explant results and notes that dramatic weight loss is linked to telogen effluvium.
Source summary and thread relationship - @lowmegatron · 2026-06-10 own thread
lowmegatron describes a human RCT of 49 people, with time-restricted eating (18-hour fasts), calorie restriction and normal eating groups. He reports hair regrowth was 18% slower with fasting, with shorter and thinner hairs. He presents increased fat oxidation and oxidative stress as the cause of hair stem cell death, which topical vitamin E mitigated in mice.
Source summary and thread relationship - @lowmegatron · 2026-06-11 original
lowmegatron says vitamin E helped hair follicle stem cells survive fasting. The quoted earlier post cites rodent work in which fasting raises cortisol and epinephrine, lipolysis and free fatty acids, and the free fatty acids cause stem-cell apoptosis. It also cites topical vitamin E preventing this in fasted mice, and a human follicle explant model.
Source summary and thread relationship - @1immortals1 · 2026-06-11 original
Anecdotal account of a 60-year-old man with biological age of 38 achieved through 22 years of consistent lifestyle practices: morning sunlight exposure, 18-hour time-restricted eating, daily 8-mile walking, cold showers, and dark sleep environment.
Source summary and thread relationship - @1immortals1 · 2026-06-12 original
Author's personal 5-day water fast experience with detailed subjective account of hunger, brain fog on day 2, mental clarity on day 3-5, autophagy and ketone metabolism explanation, and monthly fasting practice.
Source summary and thread relationship - @lowmegatron · 2026-06-16 own thread
lowmegatron claims cortisol, glucagon and adrenaline inhibit T4-to-T3 conversion and raise reverse T3. He lists modifiable causes of high cortisol and adrenaline: poor sleep, too few carbs, sodium, potassium, magnesium or calcium, fasting, chronic caloric restriction, noise, shallow breathing, black coffee on an empty stomach, and constant stimulation. He suggests acerola vitamin C, L-theanine and glycine may help.
Source summary and thread relationship - @lowmegatron · 2026-06-16 own thread
lowmegatron argues thyroid function adjusts to energy availability, so undereating or overexertion can reduce thyroid hormone production, conversion or tissue response and lower metabolic rate. He warns against combining fasting with intense exercise and suggests mild caloric restriction balanced with adequate intake.
Source summary and thread relationship - @lowmegatron · 2026-06-24 original
lowmegatron says hypothyroidism doubles noradrenaline, which he links to greying and hair loss. He cites a case in which greying reversed after IV levothyroxine, rodent T3 results, a human greying study and fasting-related follicle research, and says greying must be caught early to reverse.
Source summary and thread relationship - @jamesbondwisdom · 2026-06-28 original
jamesbondwisdom claims most young men's hair loss stems from a self-created hormonal environment: high cortisol, excess body fat raising aromatase and DHT, poor sleep lowering growth hormone, and seed oil inflammation. He advises cutting caffeine, sleeping better, avoiding seed oils and using rosemary oil with weekly microneedling, and says finasteride stops working when stopped.
Source summary and thread relationship - @1immortals1 · 2026-07-16 original
Author explains intermittent fasting mechanism via mTOR suppression and AMPK activation, enabling autophagy (cellular self-cleaning). Cites Nobel Prize-winning research and lists hormonal, metabolic, inflammatory, and cognitive benefits with practical 16:8 protocol.
Source summary and thread relationship - @lowmegatron · 2026-07-16 original
TSH can be lowered by substances other than thyroid hormones; fasting reduces TSH secretion and cortisol elevation mediates this effect, suggesting mild cortisol elevations can significantly decrease TSH levels.
Source summary and thread relationship - @lowmegatron · 2026-07-23 original
lowmegatron argues that extreme caloric restriction and intermittent fasting cause hair loss. In his account, stress hormones raise lipolysis, and free fatty acids and fat oxidation kill hair follicle stem cells. Topical vitamin E prevented this in fasted mice. He cites an 18% slower hair growth in a human trial of 18-hour fasting.
Source summary and thread relationship - @lowmegatron · 2026-07-29 original
Exercise with inadequate caloric intake suppresses thyroid hormone conversion (low-T3 syndrome) as energy preservation response. Study of 27 untrained women at 70% aerobic capacity found abrupt T3 reduction (16%) and fT3 reduction (9%) between 19.0 and 25.0 kcal/kg lean body mass, and fT4 increase (11%) and rT3 increase (22%) between 10.8 and 19.0 kcal/kg. Increasing energy availability to 25 kcal/kg LBM without reducing exercise may prevent athletic amenorrhea.
Source summary and thread relationship - @jamesbondwisdom · 2026-08-21 original
The author explains that hair shedding lags its trigger (stress, crash dieting, illness) by 2-3 months as follicles move to the resting phase. He advises looking back about 3 months for causes and judging treatments no sooner than month 4, and calls crash diets a common trigger.
Source summary and thread relationship - @lowmegatron · 2026-08-22 original
Critique of low-calorie, low-carbohydrate diet recommendations for hypothyroid patients: caloric restriction and low carbohydrate intake impair T4-to-T3 conversion, worsening hypothyroidism while requiring progressive caloric reduction. Five peer-reviewed studies cited showing calorie and carbohydrate effects on thyroid hormone metabolism.
Source summary and thread relationship - @lowmegatron · 2026-08-26 original
Fasting lowers thyroid hormone (T3) while also lowering TSH, causing a differential response in thyroid axis. Standard testing with only T4 and TSH during fasting/calorie restriction gives incorrect clinical impression because T3 conversion drops and TSH/T3 relationship reverses from the assumed pattern. Meta-analysis of 15 studies shows significant reductions in FT3 and total T3, moderate TSH decrease, and no significant FT4 change during fasting.
Source summary and thread relationship - @jamesbondwisdom · 2026-08-29 original
The author claims aggressive caloric restriction causes telogen effluvium 2-4 months later, through drops in leptin, T3 and IGF-1 and inadequate protein. They advise a deficit of no more than 500-700 calories, at least 1.2g/kg protein, weekly refeeds, and iron and zinc supplementation.
Source summary and thread relationship - @1immortals1 · 2026-08-29 original
Autophagy is a cellular recycling process activated during 16-24 hour fasting, discovered by Nobel Prize winner Yoshinori Ohsumi in 2016. Fasting activates cellular maintenance that clears misfolded proteins, destroys precancerous cells, recycles damaged mitochondria, reduces inflammation. Requires no cost, activates with 16-hour fasts 2-3 times weekly (skip breakfast, eat noon-8pm).
Source summary and thread relationship - @lowmegatron · 2026-09-09 original
With hypothyroidism, the 'calories in calories out' model must account for T3 effects on resting metabolism. Lower T3 activity reduces 'calories out' (metabolic rate). Insufficient available calories further reduces T4 to T3 conversion. Before applying CICO model, verify T3 optimization via blood test and confirm T3 reaches cells via basal temperature. Embedded quoted account details how severe caloric restriction causes drops in T3 and metabolic adaptation; T3 repletion reverses hypometabolism and restores metabolic rate.
Source summary and thread relationship - @1immortals1 · 2026-09-10 original
David Sinclair, Harvard genetics professor, reversed epigenetic age ~10 years using daily resveratrol and related compounds. Sinclair takes resveratrol, NMN, metformin, and vitamin D; publishes blood work showing younger epigenetic age. Resveratrol activates sirtuins (DNA repair, anti-inflammatory); 2006 study showed 31% lifespan extension in obese mice. Recommended protocol: 500mg trans-resveratrol daily with fat source plus 1g NMN; cost $20–30/month.
Source summary and thread relationship - @lowmegatron · 2026-09-11 original
Caloric restriction and fasting reduce tissue uptake of thyroid hormones, with T4 transport more affected than T3. This tissue-level effect may underestimate problems during stress. Embedded quote expands on multiple causes of tissue-level hypothyroidism beyond blood tests.
Source summary and thread relationship - @1immortals1 · 2026-09-12 original
Valter Longo's Fasting Mimicking Diet (FMD) provides 800 cal/day for 5 days at specific macronutrient ratios to mimic fasting benefits; clinical trial showed reduced aging biomarkers, diabetes risk, cardiovascular disease risk, and cancer risk while preserving lean mass. Commercial version (ProLon) $250; DIY version ~$25.
Source summary and thread relationship - @lowmegatron · 2026-09-16 own thread
lowmegatron quotes Ray Peat saying that doctors followed a textbook claim that anyone loses weight below 1700 calories. Peat says a ward study found some women, especially chronic dieters, maintained weight on 700 calories due to adaptations to poorly balanced dieting.
Source summary and thread relationship - @lowmegatron · 2026-09-19 original
Optimal thyroid hormone production requires adequate caloric and carbohydrate intake; repost of quoted account citing starvation increases reverse T3, carbohydrate restriction lowers T3, exercise while starved worsens thyroid suppression, with PMID citations.
Source summary and thread relationship