Creatine
34 associated posts. These are attributed summaries; original text remains at the linked X post and in the local archive.
- @lowmegatron · 2025-10-16 original
The author states that blocking the glucocorticoid receptor lowers glucose and insulin in obese, diabetic mice, and that receptor activation raises free fatty acids. They list interventions said to help lower cortisol. The embedded lowmegatron post quotes a suggestion that coffee's anti-diabetic effect involves inhibiting 11β-HSD1.
Source summary and thread relationship - @lowmegatron · 2025-11-06 original
The author claims creatine decreases the stress-induced cortisol increase, quoting a study in trained swimmers where short-term creatine suppressed the cortisol response to high-intensity swim sprinting. The quoted post lists markers of stress.
Source summary and thread relationship - @lowmegatron · 2025-11-07 original
The author states that creatine increases grip strength by increasing energy availability, and that grip strength predicts cardiovascular risk, frailty, cognitive impairment and all-cause mortality. The post quotes study text on a 15% rise in mean power output after creatine and the link to PCr availability for ATP synthesis. The embedded quoted post (lowmegatron) claims creatine suppresses the exercise-induced cortisol response in trained swimmers.
Source summary and thread relationship - @lowmegatron · 2025-11-21 original
The post author says endotoxin raises cortisol and that chronically elevated cortisol can cause low testosterone, weight gain, insulin resistance, type 2 diabetes and depression. They quote a human endotoxin-administration study reporting dose-related rises in inflammatory markers, cortisol and norepinephrine. The embedded quoted post from lowmegatron says blocking the glucocorticoid receptor lowers glucose and insulin in obese diabetic mice. It also lists many things it says help lower cortisol.
Source summary and thread relationship - @lowmegatron · 2025-11-26 own thread gap
lowmegatron clarifies an earlier post: in the line "It also damages the brain, heart, and other internal tissues," "it" refers to lipofuscin, not creatine. The parent post is not supplied.
Source summary and thread relationship - @lowmegatron · 2025-11-27 original
The author states that creatine powers cancer-killing T cells. The post quotes text saying creatine supplementation in mice significantly suppressed tumor growth across multiple mouse tumor models, acting as a 'molecular battery' that conserves bioenergy for T cell activity.
Source summary and thread relationship - @lowmegatron · 2025-11-27 original
The author says decreased thyroid hormone conversion is associated with worse physical performance and lower grip strength in older men. The explanation is that T4 converted to rT3 instead of T3 lowers energy production. A quoted study excerpt reports rT3 rising with age and disease, and low T3 syndrome linked to lower physical performance. An embedded lowmegatron post says creatine increases grip strength by raising energy availability.
Source summary and thread relationship - @lowmegatron · 2025-12-02 own thread
lowmegatron gives a list of claimed ways to lower serotonin. He says PUFAs, estrogen, vitamin E or B1 deficiency and elevated free fatty acids raise it. He says zinc, niacinamide, aspirin, creatine, gelatin/glycine, vitamin E, vitamin D, L-theanine, inosine, coffee with food, calcium, magnesium, aged cascara sagrada, quinine, lysine and ginger lower it or help. He names antiserotonin drugs lisuride, cyproheptadine, memantine and famotidine.
Source summary and thread relationship - @lowmegatron · 2025-12-02 own thread
lowmegatron describes his own elevated prolactin (600 mIU/L, about 28 ng/mL) lasting a few months, which he says resolved with incandescent lighting at his workspace, 10 mg P5P after breakfast and 4 g creapure creatine daily. He says it also seemingly worked for two other people.
Source summary and thread relationship - @lowmegatron · 2025-12-15 original
The author says creatine supplementation improves memory and cognition in the elderly, with 5 g/day improving results in a couple of weeks. They quote a study whose authors discuss ATP resynthesis as a possible mechanism but say energy supply may not be the major factor.
Source summary and thread relationship - @lowmegatron · 2026-01-10 own thread
lowmegatron claims creatine reduces stress-induced increases in cortisol. The quoted study says more than 5 days of creatine combined with resistance exercise was sufficient to increase testosterone and decrease cortisol concentrations.
Source summary and thread relationship - @lowmegatron · 2026-02-17 original
Creatine supplementation blunts exercise-induced serotonin increases, potentially preventing central fatigue and depression; mechanisms involve reduced brain serotonin and improved work capacity.
Source summary and thread relationship - @lowmegatron · 2026-04-20 original
24-week randomized controlled trial in 60 vulnerable older women found creatine monohydrate combined with resistance training improved upper body strength, lower body strength, and lean muscle mass more than training or creatine alone.
Source summary and thread relationship - @lowmegatron · 2026-04-30 original
Exercise combined with creatine supplementation increases mitochondrial biogenesis more than either intervention alone in rats; mitochondrial biogenesis disruption causes metabolic and neurodegenerative disease.
Source summary and thread relationship - @lowmegatron · 2026-06-01 original
Explanation of reverse T3 elevation as stress marker; cortisol and other counterregulatory hormones shift T4 conversion toward rT3 while raising free fatty acids that impair thyroid function; lists interventions to lower cortisol and suggests T3:T4 ratio optimization in levothyroxine users.
Source summary and thread relationship - @lowmegatron · 2026-06-01 original
Evidence-based review of cortisol's role in glucose dysregulation in diabetes; cites clinical and animal studies showing cortisol effects on blood sugar, insulin resistance, and reversal with glucocorticoid receptor blockade; discusses mechanisms and dietary strategies affecting cortisol.
Source summary and thread relationship - @lowmegatron · 2026-06-05 original
Author argues over-exercise lowers active thyroid hormone T3 and TSH (via cortisol elevation), potentially misleading those monitoring TSH. Notes stress also lowers T3 and TSH. Cites study showing exhaustive exercise decreases free T3 by 24 hours into recovery with inverse cortisol relationship. Suggests increasing carbohydrates, calories, or creatine; recommends generative over degenerative exercise.
Source summary and thread relationship - @1immortals1 · 2026-06-16 original
Creatine monohydrate enhances cognitive function beyond muscle building by increasing ATP availability to the brain, improving working memory, processing speed, mental fatigue, and depression symptoms; particularly beneficial for vegetarians with lower dietary baseline.
Source summary and thread relationship - @1immortals1 · 2026-06-29 original
Author explains creatine's cognitive benefits alongside its muscle effects, citing brain energy metabolism and human studies on working memory and sleep deprivation resilience.
Source summary and thread relationship - @lowmegatron · 2026-07-02 original
Ray Peat quote on causes of hypothyroidism including fasting, stress, aerobic exercise, legumes, unsaturated fats, carotene, undercooked cruciferous vegetables; author notes TSH lowering effect; embedded post by lowmegatron on over-exercising lowering T3 and TSH via cortisol.
Source summary and thread relationship - @1immortals1 · 2026-07-03 original
Author explains that most commercial pre-workout supplements use underdosed ingredients and proprietary blends to obscure true doses, relying on stimulant effects and side effects to create perceived efficacy. Provides clinically effective doses for active compounds and cost comparison for individual purchasing.
Source summary and thread relationship - @1immortals1 · 2026-07-05 original
Author explains amino acid spiking in protein powders—addition of cheap amino acids like glycine, taurine, and creatine to inflate nitrogen-based protein measurements while reducing functional protein content. Provides detection methods via ingredient lists, leucine content verification, and third-party lab verification.
Source summary and thread relationship - @1immortals1 · 2026-07-06 original
Creatine as a cognitive enhancer: mechanism via ATP recycling; claims of improvements in working memory, processing speed, mental fatigue, memory consolidation, neuroprotection, depression symptoms, and vegetarian cognitive function; recommendation of 5g daily creatine monohydrate.
Source summary and thread relationship - @lowmegatron · 2026-07-13 original
Ray Peat quoted on athletic training slowing pulse via cortisol-mediated thyroid suppression as adaptation, with consequence of sterility in both sexes. Embedded quote discusses over-exercise lowering active T3 hormone via cortisol and prolactin mechanisms; carbohydrate/calorie support and creatine mentioned as potential aids.
Source summary and thread relationship - @1immortals1 · 2026-07-21 original
Discusses creatine's mechanisms in brain ATP regeneration and effects on working memory, processing speed, cognitive stress resilience, mental fatigue, and mood; compares creatine evidence to marketed nootropics; recommends 5g daily unflavored creatine monohydrate.
Source summary and thread relationship - @1immortals1 · 2026-07-27 original
Creatine monohydrate supplementation (5g daily) improves cognitive performance and mood via ATP availability to brain; review of clinical evidence including working memory, processing speed, IQ gains, mental fatigue reduction, depression symptom improvement, and neuroprotection; notes bodybuilders discovered cognitive benefits accidentally and disciplines remain siloed in literature.
Source summary and thread relationship - @lowmegatron · 2026-08-12 own thread
The author claims creatine reduces stress-induced cortisol increases. Quotes a study suggesting more than 5 days of creatine with resistance exercise increased testosterone and decreased cortisol concentrations.
Source summary and thread relationship - @lowmegatron · 2026-08-17 original
Author lists interventions claimed to decrease chronically elevated cortisol, including light exposure, dietary fats, micronutrients, supplements, and lifestyle factors. Quoted source discusses mold-induced stress lowering thyroid hormone T3 conversion and successful T3 supplementation in four patients previously unresponsive to levothyroxine.
Source summary and thread relationship - @1immortals1 · 2026-08-19 original
Creatine supplementation is primarily marketed for muscle but has stronger evidence for brain effects. Meta-analyses show creatine improves memory and processing speed, especially in sleep-deprived, vegetarian, and older adults. Brain creatine stores deplete under stress, sleep loss, and cognitive load. Single high-dose creatine during sleep deprivation partially recovered cognitive performance and brain energy markers for ~9 hours. Vegetarians show largest cognitive gains because dietary creatine comes from meat. Protocol: 5g creatine monohydrate daily, $10/month.
Source summary and thread relationship - @lowmegatron · 2026-08-20 original
Author argues creatine lowers lipofuscin (aging pigment from polyunsaturated fat damage) and discusses mechanisms involving antioxidants, diet composition, hormone ratios, and protein turnover, citing animal studies and quotes from Ray Peat on lipofuscin formation and proteolytic enzyme inhibition.
Source summary and thread relationship - @lowmegatron · 2026-08-27 original
Author presents study findings that a single high dose of creatine (0.2 g/kg) protects cognitive function during sleep deprivation by increasing brain energy availability, with effects comparable to lower-dose loading protocols.
Source summary and thread relationship - @lowmegatron · 2026-09-03 original
Dietary and supplemental creatine is associated with lower depression risk in women; creatine augmentation of SSRIs and CBT shows faster and greater improvement in depression scores; creatine supports brain energy production and recovery from traumatic brain injury.
Source summary and thread relationship - @lowmegatron · 2026-09-09 original
Creatine may help some migraine sufferers. Thalamic creatine is low in people with migraine, reducing energy reserve in the region that gates pain signaling. Research shows creatine improves traumatic headache but not migraine specifically. Many internet reports describe migraine improvement with creatine. Embedded quoted account discusses hypoglycemia as migraine trigger and cites Ray Peat on liver function and treatment with fruit juice.
Source summary and thread relationship - @1immortals1 · 2026-09-15 original
Claims PQQ (pyrroloquinoline quinone) is the only over-the-counter compound that triggers mitochondrial biogenesis via PGC1-alpha activation, building new mitochondria rather than repairing existing ones. Lists purported effects on mitochondrial density, sleep, inflammation (CRP), cognition, and synergy with CoQ10. Recommends dosing and brands with pricing.
Source summary and thread relationship