Aspirin
80 associated posts. These are attributed summaries; original text remains at the linked X post and in the local archive.
- @lowmegatron · 2025-10-07 original
The author summarizes Ray Peat's comments on endotoxin from leaky gut. The summary covers links to aging, stress, cancer, inflammation, thyroid, estrogen and cholesterol, plus dietary and other factors said to raise or lower endotoxin effects.
Source summary and thread relationship - @lowmegatron · 2025-10-11 original
Author says aspirin may prevent colorectal cancer by improving gut microbiota, quoting a paper abstract. The embedded quoted post relays an anecdote about actor Matthew McConaughey's mother beating two cancers 'on aspirin'.
Source summary and thread relationship - @lowmegatron · 2025-10-12 original
The author lists substances and practices that he claims lower or block serotonin, including aspirin, L-theanine, thiamine, glycine, taurine, T3, ginger, cyproheptadine, vitamin E, magnesium, DHEA, progesterone, testosterone/DHT, lysine, and avoiding seed oils. The quoted context is a Ray Peat line about serotonin overproduction and hibernation.
Source summary and thread relationship - @lowmegatron · 2025-10-16 original
The author lists supplements, foods and habits they say protect against polyunsaturated fat (PUFA) and seed oil effects. The lists cover reducing lipid peroxidation, lowering free fatty acids and supporting glucuronidation and sulfation. The author also advises eating mostly saturated fats and avoiding high-PUFA oils. The embedded lowmegatron post has an overlapping saturated fat/PUFA list plus a note on olive oil.
Source summary and thread relationship - @lowmegatron · 2025-10-16 original
The author states that blocking the glucocorticoid receptor lowers glucose and insulin in obese, diabetic mice, and that receptor activation raises free fatty acids. They list interventions said to help lower cortisol. The embedded lowmegatron post quotes a suggestion that coffee's anti-diabetic effect involves inhibiting 11β-HSD1.
Source summary and thread relationship - @lowmegatron · 2025-10-23 original
Author claims negative ion generators lower serotonin and histamine, and that oceans and waterfalls naturally produce negative ions. Bullets and a Ray Peat quote say positive ions raise serotonin and negative ions reduce brain serotonin and histamine. The embedded lowmegatron post lists substances and practices said to lower or block serotonin.
Source summary and thread relationship - @lowmegatron · 2025-10-26 original
The author says aspirin may slow fatty liver disease, quoting a prospective study in which daily aspirin use was associated with less severe NAFLD/NASH histology and lower risk of progression to advanced fibrosis. The author lists proposed mechanisms and notes that aspirin was not prescribed and that users were compared with non-users.
Source summary and thread relationship - @lowmegatron · 2025-11-02 original
The post begins mid-quote with Ray Peat saying vitamin K protects arteries and bones and that aspirin and vitamin K are bone-building supplements. It adds quoted excerpts from an aspirin study in rodents and one in humans on bone loss and bone mineral density. The embedded earlier post quotes Peat on vitamin K, CO2 and calcium handling, followed by K1/K2 fracture, bone and arterial calcification excerpts.
Source summary and thread relationship - @lowmegatron · 2025-11-04 original
Author says they have heard methylene blue, aspirin and caffeine might help mitigate brain X-ray damage. The post quotes Ray Peat naming thyroid hormone, magnesium, aspirin and coffee as protective, and an excerpt on the radiation bystander effect. The embedded post links coffee intake to lower colon cancer recurrence and mortality.
Source summary and thread relationship - @lowmegatron · 2025-11-06 original
The post shares a Ray Peat quotation on minimizing the harmful effects of serotonin through diet, light and specific agents. The quoted lowmegatron post lists compounds and practices said to lower or block serotonin.
Source summary and thread relationship - @lowmegatron · 2025-11-09 original
The author lists claimed effects of high prolactin, its claimed causes (stress, serotonin, hypothyroidism, low zinc, seed oils, etc.) and things he says may lower it (zinc, DHT, coffee, aspirin, bright light, progesterone, thyroid optimization, etc.).
Source summary and thread relationship - @lowmegatron · 2025-11-10 original
The post quotes Ray Peat saying serotonin reuptake inhibitor antidepressants increase prolactin and were found to cause osteoporosis after prolonged use. The embedded lowmegatron post lists symptoms attributed to high prolactin, causes of high prolactin, and factors said to lower it.
Source summary and thread relationship - @lowmegatron · 2025-11-11 original
The post claims aspirin can boost dopamine and may help in Parkinson's. It says aspirin increases tyrosine hydroxylase, which is needed to make dopamine, and that this was shown in lab-grown brain cells and live mice. The embedded lowmegatron post lists substances and practices claimed to lower or block serotonin.
Source summary and thread relationship - @lowmegatron · 2025-11-12 own thread gap
lowmegatron quotes a statement that the speaker has not tried magnesium salicylate, finds most magnesium compounds irritating to the intestine, and has mixed baking soda with salicylic acid, which seems similar to aspirin. The quote says magnesium salicylate, popular for arthritis, releases salicylic acid in the intestine and blood.
Source summary and thread relationship - @lowmegatron · 2025-11-12 original
The author claims polyunsaturated fats such as linoleic and arachidonic acid interfere with vitamin D binding to DBP, while saturated fats do not. The embedded lowmegatron post lists strategies to protect against seed oils and polyunsaturated fats, including supplements, foods and fats to eat or avoid.
Source summary and thread relationship - @lowmegatron · 2025-11-13 original
The post quotes Ray Peat saying he seldom recommends oral supplements because of contaminants, except aspirin dissolved in warm water. He uses vitamin D on the skin in oil in winter, and says fat-soluble vitamins absorb through skin at roughly 5%. He also says water-soluble vitamins absorb poorly but can be absorbed significantly over a large area. The embedded lowmegatron post quotes Peat on winter vitamin D from milk, liver, vitamin D oil on skin and occasional ultraviolet light.
Source summary and thread relationship - @lowmegatron · 2025-11-14 original
Post quotes Ray Peat on skin cancer: avoid unsaturated fats, aspirin, caffeine and orange juice are protective, and keeping TSH low matters because it stimulates melanoma growth.
Source summary and thread relationship - @lowmegatron · 2025-11-19 original
The author advises following the money when seeing anti-coffee or anti-aspirin stories, with a link. The embedded post says aspirin may slow fatty liver disease, citing an observational study of daily aspirin users and listing proposed mechanisms.
Source summary and thread relationship - @lowmegatron · 2025-11-21 original
Author lists conditions said to be caused by bacterial endotoxin entering the bloodstream in leaky gut, then lists nutrients, drugs, foods and lifestyle factors said to reduce endotoxin or its inflammatory effects. The embedded post claims pregnenolone curbs alcohol cravings partly through TLR4 inhibition.
Source summary and thread relationship - @lowmegatron · 2025-11-21 original
The post author says endotoxin raises cortisol and that chronically elevated cortisol can cause low testosterone, weight gain, insulin resistance, type 2 diabetes and depression. They quote a human endotoxin-administration study reporting dose-related rises in inflammatory markers, cortisol and norepinephrine. The embedded quoted post from lowmegatron says blocking the glucocorticoid receptor lowers glucose and insulin in obese diabetic mice. It also lists many things it says help lower cortisol.
Source summary and thread relationship - @lowmegatron · 2025-11-22 original
Author describes a case report of a woman whose manic symptoms after gastrectomy for obesity reportedly resolved within two weeks on 1 g/day activated charcoal, with a quoted mechanism proposing a brain–gut axis. The embedded lowmegatron post claims bacterial endotoxin from leaky gut causes many conditions and lists interventions said to help with endotoxin.
Source summary and thread relationship - @lowmegatron · 2025-11-24 original
The author compiles excerpts from three cited papers on aspirin in COPD. Two are observational and link aspirin use to lower mortality in critically ill patients and to fewer exacerbations, less dyspnea and better quality of life. The third is a 4-week placebo-controlled trial of inhaled aspirin in 59 people with moderate COPD, reporting lower inflammatory markers and improved lung function at 250 mg. The embedded Medscape post is general COPD content.
Source summary and thread relationship - @lowmegatron · 2025-11-24 original
The author claims that 81 mg aspirin started preconception raised live-birth rates in women with high C-reactive protein. They report a 34% relative (15% absolute) increase versus placebo, from a secondary analysis of a randomized trial. The embedded lowmegatron post says aspirin lowers COX-2, interferes with seed oil inflammatory effects and reduces pancreatic damage in experimental pancreatitis.
Source summary and thread relationship - @lowmegatron · 2025-11-25 original
The author claims much mental illness begins in the gut because bacterial endotoxin poisons mitochondria and leaky gut lets more endotoxin into circulation. They quote a systematic review and meta-analysis on gut dysbiosis markers in severe mental illness and chronic fatigue. They then list nutrients, foods and other factors they say reduce endotoxin or endotoxin-driven inflammation.
Source summary and thread relationship - @lowmegatron · 2025-11-27 original
The post asks whether supplements can safely raise serum androgens in men if diet is good, and answers with a Ray Peat quote. Peat says pregnenolone has favorable effects. He also says thyroid or aspirin can improve the androgen-to-cortisol/estrogen ratio, and that low-dose DHEA can help if thyroid function is good. An embedded post by lowmegatron links subclinical hypothyroidism to low testosterone and ED in men.
Source summary and thread relationship - @lowmegatron · 2025-11-28 original
The post quotes Ray Peat saying hypothyroidism raises estrogen and nitric oxide and lowers serum osmolarity, and that several agents can correct the fluid imbalance in Ménière's disease. It adds a quoted paper excerpt associating thyroid diseases with Ménière's. The embedded earlier post gives study abstracts on thyroid hormone use, pregnancy and the menstrual cycle in Ménière's disease.
Source summary and thread relationship - @lowmegatron · 2025-11-29 original
The post claims rosacea and other skin conditions are often due to gut events, citing a Ray Peat quote on bacterial endotoxin and a case report of rosacea remission after reduced bowel transit time. The embedded quoted post (lowmegatron) lists conditions attributed to endotoxin from leaky gut and a long list of substances said to help with endotoxin.
Source summary and thread relationship - @lowmegatron · 2025-11-30 own thread
lowmegatron lists factors he claims help control endotoxin. These include optimizing T3, coffee (including decaf), a low omega-6 diet, vitamin C, aspirin, fixing sleep and circadian disorganization, activated charcoal, naringenin, benfotiamine, glycine, aged cascara sagrada, cooked mushrooms, progesterone, pregnenolone and zinc.
Source summary and thread relationship - @lowmegatron · 2025-12-02 own thread
lowmegatron gives a list of claimed ways to lower serotonin. He says PUFAs, estrogen, vitamin E or B1 deficiency and elevated free fatty acids raise it. He says zinc, niacinamide, aspirin, creatine, gelatin/glycine, vitamin E, vitamin D, L-theanine, inosine, coffee with food, calcium, magnesium, aged cascara sagrada, quinine, lysine and ginger lower it or help. He names antiserotonin drugs lisuride, cyproheptadine, memantine and famotidine.
Source summary and thread relationship - @lowmegatron · 2025-12-02 own thread
lowmegatron says aspirin minimizes stress-induced prolactin increases, quoting a study finding a significantly reduced total prolactin response to stress after aspirin. He notes the study used 800 mg and suggests lower doses may work in most cases (his opinion).
Source summary and thread relationship - @lowmegatron · 2025-12-11 original
The post quotes Ray Peat on accumulated unstable fats making endotoxin exposure more inflammatory and stressing the lipid-rich brain with age. The embedded quote, from lowmegatron, lists conditions attributed to endotoxin from leaky gut and a long list of nutrients, drugs and habits said to help.
Source summary and thread relationship - @lowmegatron · 2025-12-17 original
The author shares Ray Peat's view that hypothyroidism and bowel inflammation are key in gout, and that raw carrot salad, aspirin and correcting thyroid function usually resolve it. They cite a paper reporting more hyperuricemia and gout in hypothyroid patients. Further Peat excerpts describe uric acid as an antioxidant and anti-inflammatory defense, and gout symptoms as possibly driven by intestinal endotoxin. The embedded post from lowmegatron reports that coffee intake is associated with lower gout risk.
Source summary and thread relationship - @lowmegatron · 2026-01-09 original
Aspirin reduces stress-induced increases in prolactin, cortisol, and ACTH according to a cited study (PMID: 11740295).
Source summary and thread relationship - @lowmegatron · 2026-01-10 own thread
lowmegatron claims salicylate, an aspirin metabolite, lowers tissue cortisol regeneration by reducing 11β-HSD1. He quotes research on salsalate/salicylate improving glucose tolerance and reducing adipose 11β-HSD1 in mice and men.
Source summary and thread relationship - @lowmegatron · 2026-01-10 own thread
lowmegatron claims aspirin itself lowers stress-induced increases in ACTH and cortisol, quoting a study saying aspirin blunted ACTH and cortisol and was associated with reduced cortisol after exercise.
Source summary and thread relationship - @lowmegatron · 2026-01-12 original
DHEA improves insulin sensitivity and reduces abdominal fat through decreased local cortisol production via 11β-HSD1 inhibition; coffee, vitamin D, and aspirin share this mechanism.
Source summary and thread relationship - @lowmegatron · 2026-01-13 original
Comprehensive compilation of potential health benefits of aspirin across multiple mechanisms: antibiofilm activity, cancer prevention, dopamine pathway stimulation, immune regulation, metabolic effects, cardiovascular protection, liver health, bone regeneration, and metabolic flexibility. No commercial promotion included.
Source summary and thread relationship - @lowmegatron · 2026-01-14 original
11β-HSD1 inhibitors under investigation for type 2 diabetes treatment. Cortisol raises blood sugar and free fatty acids (necessary in healthy states but chronically elevated in dysregulation). Coffee, aspirin, and vitamin D reduce 11β-HSD1 activity and associated with reduced diabetes risk.
Source summary and thread relationship - @lowmegatron · 2026-01-17 original
Ray Peat 2021 statement on anti-serotonin and anti-inflammatory agents (antihistamines, aspirin, anticoagulants) for treating unnamed infection, and ACE2 protective enzyme upregulation as core treatment approach. Embedded post discusses furin cleavage site and aspirin mechanism for COVID.
Source summary and thread relationship - @lowmegatron · 2026-01-20 original
Explanation of migraine mechanism involving seed oils, linoleic acid, serotonin release, vasoconstriction, and blood sugar; case of William Brown's symptom improvement on very low-fat diet.
Source summary and thread relationship - @lowmegatron · 2026-01-26 original
Author says aspirin supply shortages in the UK should never happen. The post quotes text stating 86% of respondents could not supply aspirin in the previous seven days, and attributes the shortage to manufacturing delays and low NHS prices.
Source summary and thread relationship - @lowmegatron · 2026-01-26 original
Author says stress increases COX-2, which drives some cancer metastasis, and that aspirin inhibits COX-2. The post quotes a mouse chronic-stress lymphatic metastasis paper and a colorectal cancer aspirin paper. The embedded post links aspirin and COX inhibition to anti-cancer effects in prostate cancer.
Source summary and thread relationship - @lowmegatron · 2026-01-27 original
Knowledge claim on vitamin K2's anti-estrogenic and bone-density effects, with Ray Peat quote and mechanism note; product mentioned without affiliation claim.
Source summary and thread relationship - @lowmegatron · 2026-01-28 original
Ray Peat quoted on T3 effects on aromatase inhibition and testosterone efficacy in men. Claims T3 lowers aromatase; elevated aromatase from stress lowers testosterone and increases estrogen. Discusses how T3, aspirin, pregnenolone, or progesterone inhibit aromatase and improve testosterone effectiveness.
Source summary and thread relationship - @lowmegatron · 2026-01-29 own thread
Quotes claims that stored PUFA released by stress or hunger slows metabolism; niacinamide lowers free fatty acids; small amounts of coconut oil aid fat oxidation; aspirin reduces stress-related free fatty acid rises; thyroid supplements are reasonable until the saturated-to-PUFA ratio is about 2:1. Includes a personal anecdote of losing about two pounds weekly with a tablespoon of coconut oil.
Source summary and thread relationship - @lowmegatron · 2026-02-09 original
Stretching has anti-inflammatory and anti-cancer effects comparable to aspirin pathways; stretching reduced tumor volume 52% in mice; embedded post on stress-induced COX-2 driving cancer metastasis and aspirin's inhibitory effects.
Source summary and thread relationship - @lowmegatron · 2026-02-15 original
T3, aspirin, and pregnenolone or progesterone inhibit aromatase and enhance testosterone effectiveness; mechanism involves reducing estrogen excess from stress-induced aromatase elevation.
Source summary and thread relationship - @lowmegatron · 2026-03-01 original
Author shares Ray Peat's explanation that defensive action prevents stress ulcer formation via reduced serotonin, protecting against cortisol and circulation/energy disruption; notes endotoxin and prostaglandins activate similar stress systems, while progesterone and aspirin provide protection.
Source summary and thread relationship - @lowmegatron · 2026-03-02 original
Low dose aspirin is associated with lower depression risk, while other NSAIDs are associated with higher depression risk.
Source summary and thread relationship - @lowmegatron · 2026-03-07 original
Aspirin is metabolized to salicylate, which interferes with vitamin-K-dependent coagulation factors. Vitamin K significantly reduces/prevents bruising and bleeding from aspirin use. Ray Peat recommended taking vitamin K with aspirin. Case report demonstrates vitamin K correction of salicylate-induced coagulopathy.
Source summary and thread relationship - @lowmegatron · 2026-03-12 original
Bacterial endotoxin reduces REM sleep and causes depression-like symptoms including fatigue, reduced appetite and cognitive impairment. Embedded post summarizes Ray Peat commentary on endotoxin's role in aging, cancer, inflammation, and dietary/supplement interventions.
Source summary and thread relationship - @lowmegatron · 2026-03-13 original
Broda Barnes and Ray Peat quoted on gout, hypothyroidism, and thyroid therapy; Ray Peat's view of uric acid as antioxidant and anti-inflammatory. Embedded quoted post by lowmegatron on thyroid hormone treatment effects on uric acid and insulin resistance.
Source summary and thread relationship - @lowmegatron · 2026-03-25 own thread
The post text is only links. Its quoted post by lowmegatron lists claimed ways to address endotoxin, including cascara sagrada, minocycline, aspirin, cocoa, coffee, DHEA, ginger, glycine, sleep, naringenin, orange juice, pregnenolone, progesterone, probiotics, sugar, taurine, several vitamins, mushrooms and zinc, and notes PUFA-rich high-fat diets may raise endotoxin.
Source summary and thread relationship - @lowmegatron · 2026-04-01 original
Boswellia resin and Boswellic acids (especially Acetyl-11-keto-ß-boswellic acid) have anti-inflammatory and anti-cancer properties through 5-LOX and COX inhibition, reducing polyunsaturated fat-derived inflammatory molecules. Relevant to cancer prevention, arthritis, Crohn's disease, asthma, and bronchitis.
Source summary and thread relationship - @lowmegatron · 2026-04-09 original
Vitamin K2 and aspirin support bone calcification by blocking lactic acid production and stimulating bone proteins; low-dose aspirin is associated with higher bone mineral density.
Source summary and thread relationship - @lowmegatron · 2026-04-15 original
Bacterial endotoxin (LPS) lowers both TSH and thyroid hormones, creating misleading thyroid test results. Multiple dietary and supplemental compounds may reduce endotoxin burden or its effects.
Source summary and thread relationship - @lowmegatron · 2026-04-28 original
Aspirin use associated with reduced liver fibrosis and fatty liver disease; low-dose aspirin in RCT reduced liver fat; mechanistic explanation of aspirin's metabolic benefits.
Source summary and thread relationship - @lowmegatron · 2026-04-28 original
Ray Peat quote on aspirin's anti-inflammatory actions and broad metabolic benefits in context of polyunsaturated fat toxicity; shares earlier aspirin-NAFLD post.
Source summary and thread relationship - @lowmegatron · 2026-05-04 original
Author quotes Ray Peat on tremor resolution with thyroid supplementation and presents study on thyroid hormone relationship to Parkinson's motor symptoms; embeds prior post on aspirin and dopamine in Parkinson's.
Source summary and thread relationship - @lowmegatron · 2026-05-14 original
High-dose aspirin improves glucose metabolism and insulin sensitivity in type 2 diabetes by inhibiting IKKb; reduces liver glucose production, improves peripheral insulin sensitivity, and increases glucose oxidation; 2-week study showed substantial improvements; author notes risks of high-dose aspirin outweigh benefits but mechanism is informative.
Source summary and thread relationship - @lowmegatron · 2026-05-16 original
Historical and contemporary evidence on salicylates and aspirin for diabetes treatment; embedded quoted post details high-dose aspirin mechanisms and metabolic effects in type 2 diabetes.
Source summary and thread relationship - @lowmegatron · 2026-05-22 original
DHEA increases 11β-HSD2 enzyme activity, which locally inactivates cortisol to cortisone at the tissue level, independent of blood cortisol levels. This reduces cortisol's receptor activation in tissues. Elevated tissue-level cortisol, even with normal blood levels, contributes to insulin resistance, visceral fat, dyslipidemia, hypertension, cardiovascular disease, neurodegeneration, depression, anxiety, sleep impairment, immune suppression, poor wound healing, osteoporosis, muscle wasting, hormone dysregulation, and skin deterioration. Optimal DHEA dosing is 3-5 mg, 1-3 times daily. Higher doses become estrogenic; topical application combined with pregnenolone maximizes anti-cortisol effects while minimizing estrogen conversion. Coffee, aspirin, and vitamin D reduce activity of the related 11β-HSD1 enzyme.
Source summary and thread relationship - @lowmegatron · 2026-06-01 original
Practical tips for lowering prolactin and serotonin through thyroid optimization, nutrient status, dietary fat composition, light exposure, supplements, and specific compounds; includes embedded quote on cyproheptadine mechanism for SSRI sexual dysfunction.
Source summary and thread relationship - @lowmegatron · 2026-06-02 original
Study showing pomegranate juice consumption lowers blood pressure, insulin, and insulin resistance; attributes effect to tissue cortisol reduction via cortisol-recycling enzyme inhibition; notes similarity to effects of other compounds affecting these enzymes.
Source summary and thread relationship - @lowmegatron · 2026-06-02 original
Explanation of two-enzyme system (11β-HSD1 and 11β-HSD2) controlling tissue cortisol activation and inactivation; notes thyroid hormone T3 influences balance toward inactivation; contrasts pharmaceutical research with clinician ignorance of T3 assessment; lists multiple interventions affecting enzyme balance.
Source summary and thread relationship - @lowmegatron · 2026-06-03 original
Ray Peat quote on intestinal inflammation from infection and undigested starches causing endotoxin-driven insulin resistance; comprehensive list of dietary and supplement interventions claimed to reduce endotoxin and associated inflammation.
Source summary and thread relationship - @lowmegatron · 2026-06-25 original
Extended Ray Peat quotation on sunlight, skin cancer, and melanoma, emphasizing melanoma's link to estrogen and estrogenic pollutants rather than sun exposure, and protective roles of antioxidants and saturated fats; embedded quote from Jimmy Dore on basal cell carcinoma mortality.
Source summary and thread relationship - @lowmegatron · 2026-07-20 original
Niacinamide may block free radical processes and lighten skin pigment; cited study shows 4% niacinamide effective in 40% of melasma patients. Embedded quote attributes hypothyroidism as melasma cause with levothyroxine treatment reducing hyperpigmentation 80% over 1.5 years.
Source summary and thread relationship - @lowmegatron · 2026-07-21 original
Discusses aspirin's historical use and multiple biomedical properties including cancer prevention, antibiofilm activity, amyloid reduction, dopamine pathway effects, and metabolic benefits; quotes pension risk modeling and multiple research summaries; embeds Ray Peat commentary on aspirin dosing, storage, and vitamin K cofactor.
Source summary and thread relationship - @lowmegatron · 2026-07-21 own thread
lowmegatron compiles quoted study excerpts on aspirin. They cover bone regeneration, pancreatitis, memory, antiviral activity against influenza A and rhinovirus, pregnancy outcomes with elevated CRP, cytokine reduction, erectile function, autophagy as a caloric restriction mimetic, and a Ray Peat-style description of glycolysis and CO2 production.
Source summary and thread relationship - @lowmegatron · 2026-07-23 original
Author explains aspirin stomach damage mitigation by dissolving in warm water with sodium bicarbonate; cites study showing bicarbonate reduces aspirin-induced gastric mucosal cell damage from 20% to 3.4%; recommends glycine and vitamin K2 supplementation for aspirin users.
Source summary and thread relationship - @lowmegatron · 2026-07-24 original
Ray Peat on thyroid hormone T4-to-T3 conversion: requires glucose, selenium, adequate protein, and specific nutrient ratios; discusses mineral balance, estrogen interference, and optimal dosing strategies for thyroid replacement therapy including desiccated thyroid and synthetic combinations.
Source summary and thread relationship - @lowmegatron · 2026-08-11 original
Topical CO2 application accelerates bone healing and increases bone density in a rat femoral defect model. At 4 weeks, CO2-treated bones showed 4× higher healing rate (18% vs 72%), 12× greater ultimate stress, 6× greater extrinsic stiffness, 9× greater failure energy, and 37% higher volumetric bone mineral density (180 vs 248). CO2-infused water or SodaStream cylinders suggested as delivery methods. Embedded quote from lowmegatron references Ray Peat on vitamin K2 and aspirin for bone health.
Source summary and thread relationship - @lowmegatron · 2026-08-12 own thread
The author claims aspirin itself lowers stress-induced increases in ACTH and cortisol, quoting a study that aspirin blunted ACTH and cortisol after exercise.
Source summary and thread relationship - @lowmegatron · 2026-08-12 own thread
The author claims salicylate, an aspirin metabolite, lowers tissue cortisol regeneration by reducing 11β-HSD1. Quotes a paper reporting improved glucose tolerance in obese mice, reduced adipose 11β-HSD1 in men given salsalate, and this mechanism contributing to salicylates' metabolic effects.
Source summary and thread relationship - @lowmegatron · 2026-08-16 original
Ray Peat quote on bowel inflammation treatment including multiple interventions; followed by discussion of lidocaine gel for ulcerative colitis with multiple clinical study summaries showing rapid symptom relief, mucosal healing, and lymphocyte depletion with 83% response rate in larger trial.
Source summary and thread relationship - @lowmegatron · 2026-08-17 original
Author lists interventions claimed to decrease chronically elevated cortisol, including light exposure, dietary fats, micronutrients, supplements, and lifestyle factors. Quoted source discusses mold-induced stress lowering thyroid hormone T3 conversion and successful T3 supplementation in four patients previously unresponsive to levothyroxine.
Source summary and thread relationship - @lowmegatron · 2026-08-18 original
Author reports aspirin reduces Candida biofilm and interrupts yeast metabolism through PGE2 reduction, mediated by linoleic and arachidonic acids from seed oils and conventional meats. Describes lab concentrations equivalent to 500-1,000 mg aspirin and lists risk groups.
Source summary and thread relationship - @lowmegatron · 2026-09-07 original
Author quotes Ray Peat on factors supporting healthier pregnancies and postpartum outcomes, including sunlight, vitamin D, whole foods, thyroid function optimization, and specific hormones and anti-inflammatory medications.
Source summary and thread relationship - @lowmegatron · 2026-09-17 original
Thyroid hormone influences herpes zoster (shingles) outbreak severity; hypothyroidism increases recurrence risk; thyroid hormone replacement therapy reduces shingles risk by 40%.
Source summary and thread relationship