Alcohol, Addiction and Withdrawal
48 associated posts. These are attributed summaries; original text remains at the linked X post and in the local archive.
- @lowmegatron · 2025-09-30 original
Author reports that female rats take more cocaine than males and that progesterone reduces cocaine use in females in some contexts. A quoted excerpt says progesterone alone reduced reinstatement only in females, while progesterone plus atomoxetine reduced it in both sexes.
Source summary and thread relationship - @lowmegatron · 2025-10-01 original
Author claims poor glymphatic drainage causes depression and dementia, and that low-dose alcohol improves glymphatic clearance while heavy drinking is worst. The pasted mouse study excerpt found 0.5 g/kg improved glymphatic function, while 1.5 g/kg and 4 g/kg reduced it. The quoted Outdoctrination post says glymphatic dysfunction drives depression.
Source summary and thread relationship - @lowmegatron · 2025-10-02 original
The post quotes Ray Peat saying alcohol served to him acted as an antidote to allergens that would otherwise make him sick, with antioxidant effect he compares to vitamin E. The embedded lowmegatron post claims low-dose alcohol increases glymphatic drainage in mice and that light drinkers have lower depression and dementia risk.
Source summary and thread relationship - @lowmegatron · 2025-10-20 original
The author claims alcohol combined with seed oils (corn oil) causes more liver damage than alcohol with saturated fat, via increased gut permeability and endotoxin leakage. They support this with animal studies (PMID 22150547). The embedded quoted post from lowmegatron claims coffee, including decaf, lowers blood endotoxin.
Source summary and thread relationship - @lowmegatron · 2025-10-21 original
The author posts a long list of symptoms and conditions, each labeled 'Improved by CO2'. The embedded quoted post from anomalie_blue presents the list as coming from a 1958 study of 500 cases (Jackman) of CO2 treatment. That post says over 80% of patients improved and nearly 60% had complete clinical recovery.
Source summary and thread relationship - @nootropicguy · 2025-10-22 original
Author claims DSIP is an underrated peptide for addiction recovery, citing 97% success in opioid withdrawal and 87% in alcohol withdrawal, with minimal tolerance and side effects. Author says two other small open-label human trials showed similar results.
Source summary and thread relationship - @nootropicguy · 2025-10-22 own thread
nootropicguy claims DSIP restores systems damaged by addiction. He says it triggers Met-enkephalin release, potentiates GABA, blocks NMDA receptors, and normalizes sleep homeostasis, the HPA axis, circadian rhythm, and autonomic function.
Source summary and thread relationship - @lowmegatron · 2025-10-24 original
Author claims saturated fats may heal liver damage caused by seed/fish oil plus alcohol, quoting abstracts reporting that saturated-fat diets reversed alcoholic liver injury in animal models and that an epidemiological study linked saturated fat intake with lower alcoholic cirrhosis mortality.
Source summary and thread relationship - @nootropicguy · 2025-10-24 original
Author argues BDNF is not the answer for addiction because raising it in the wrong brain regions may worsen cravings and relapse risk, and that GDNF is the real anti-addiction target. The post is shared with a quoted user's question about sourcing a nasal product.
Source summary and thread relationship - @nootropicguy · 2025-10-24 own thread
nootropicguy claims GDNF underlies ibogaine's strong anti-addictive effect. He says ibogaine should be a last resort, used only with proper medical oversight because of potentially fatal cardiotoxicity.
Source summary and thread relationship - @nootropicguy · 2025-10-24 own thread
nootropicguy lists things he would consider for boosting GDNF to repair the dopaminergic system and counter addiction: sodium butyrate, co-micronized PEA plus luteolin, low dose naltrexone, rehmannia, sunlight, ALCAR, and DHA. He adds that bromantane may also help.
Source summary and thread relationship - @lowmegatron · 2025-11-07 original
The author says side sleeping may lower dementia risk by aiding glymphatic brain waste clearance, and quotes a paper speculating that the lateral position favors Aβ removal, pending human testing. The embedded quoted post (lowmegatron) describes a mouse study in which low-dose alcohol improved glymphatic function while intermediate and very high doses reduced it.
Source summary and thread relationship - @lowmegatron · 2025-11-15 original
The author shares a Ray Peat quote suggesting alcohol cravings may relate to hypothyroidism, because high serotonin activity is often present and alcohol may temporarily compensate. The embedded post from lowmegatron claims low-dose alcohol improves glymphatic drainage in mice, while higher doses impair it.
Source summary and thread relationship - @lowmegatron · 2025-11-17 original
Author states that pregnenolone lowers stress and reduces alcohol cravings at 300-500 mg/day and quotes a trial abstract (PMID 36445398) reporting reduced stress- and cue-induced craving in individuals with alcohol use disorder. The quoted post shares a Ray Peat quote linking alcohol cravings to hypothyroidism and high serotonin.
Source summary and thread relationship - @lowmegatron · 2025-11-18 original
The post claims pregnenolone helps with alcohol cravings partly by inhibiting TLR4. It supports this with a Haidut quote about naltrexone, a university statement on a mouse study of (+)-naltrexone and drinking, and excerpts on neurosteroids suppressing TLR signaling. The embedded lowmegatron post quotes a placebo-controlled human study of pregnenolone at 300 mg/day and 500 mg/day in alcohol use disorder.
Source summary and thread relationship - @lowmegatron · 2025-11-21 original
Author lists conditions said to be caused by bacterial endotoxin entering the bloodstream in leaky gut, then lists nutrients, drugs, foods and lifestyle factors said to reduce endotoxin or its inflammatory effects. The embedded post claims pregnenolone curbs alcohol cravings partly through TLR4 inhibition.
Source summary and thread relationship - @lowmegatron · 2025-11-21 original
Author says cocaine amplifies endotoxin effects while magnesium protects. Slightly elevated endotoxin is said to cause depression, T2 diabetes, low testosterone, infertility and cardiovascular disease, while very high levels can be lethal. A quoted rat study reports worse survival with magnesium deficiency. The embedded post links endotoxin to diabetes and fatty liver, quoting Ray Peat and human studies.
Source summary and thread relationship - @lowmegatron · 2025-12-23 original
The author argues that seed oils (linoleic acid) amplify alcoholic liver damage while saturated fats are protective. Support cited is a rat study, a 60-day randomized trial in severe alcoholic hepatitis comparing ghee with soybean oil, and a quoted Ray Peat excerpt.
Source summary and thread relationship - @lowmegatron · 2026-01-04 original
The author claims estrogen increases cocaine use and progesterone decreases it. The support is a quoted review abstract (rat literature) on 17β-estradiol, progesterone and allopregnanolone in cocaine-related behaviours. A Ray Peat quotation also describes estrogen as excitatory, progesterone as calming, and T3 and progesterone as mutually reinforcing.
Source summary and thread relationship - @lowmegatron · 2026-01-27 original
Knowledge claim on prednisone-induced diabetes mechanism and Ray Peat commentary on excessive replacement dosing; embedded post on pregnenolone for stress and alcohol craving reduction.
Source summary and thread relationship - @lowmegatron · 2026-02-06 original
Thiamine supplementation associated with reduced dementia risk in heavy drinkers; explains mechanism via alcohol's interference with thiamine absorption and storage needed for brain health.
Source summary and thread relationship - @lowmegatron · 2026-02-17 original
Thyroid hormone T3 accelerates alcohol clearance and corrects alcohol intolerance; low thyroid function associated with hangover severity and hypoglycemia risk from alcohol consumption.
Source summary and thread relationship - @lowmegatron · 2026-02-17 original
Alcoholic beverages contain estrogen; small amounts of alcohol have antioxidant effects but beer, wine and dark whiskey contain enough estrogen to be harmful.
Source summary and thread relationship - @lowmegatron · 2026-02-19 original
Author quotes Ray Peat on varying individual reactions to alcohol depending on thyroid activity, noting antioxidant vs. pro-oxidative effects and interaction with polyunsaturated fat consumption. Contextualizes linoleic acid as abundant polyunsaturated fat in soybean and seed oils. Includes embedded quote on thyroid hormone correcting alcohol intolerance and preventing hypoglycemia.
Source summary and thread relationship - @lowmegatron · 2026-03-20 original
Shares extended quotation attributed to Broda Barnes describing thyroid hormone's role in alcohol tolerance, liver function and hypoglycemia risk in those with low thyroid function.
Source summary and thread relationship - @lowmegatron · 2026-03-23 original
Author synthesizes research on sex hormones (estrogen and progesterone) and alcohol use disorder, presenting four main claims: estrogen linked to increased alcohol use; estrogen sensitizes reward pathways to alcohol; estrogen:progesterone ratio affects binge drinking risk; progesterone reduces stress-induced cravings. Multiple studies cited with human and animal notation.
Source summary and thread relationship - @lowmegatron · 2026-03-25 own thread
The post text is only links. Its quoted post by lowmegatron claims thyroid hormone determines alcohol tolerance and that T3 speeds alcohol clearance, quoting Broda Barnes that people with low thyroid function tolerate alcohol poorly, with sluggish livers and possible hypoglycemia.
Source summary and thread relationship - @lowmegatron · 2026-04-27 original
TSH activates TLR4 endotoxin receptor, participating in inflammation and potentially insulin resistance via macrophage infiltration and inflammatory signaling. Quoted research suggests targeting TSH may have therapeutic benefits against metabolic disorders. Embedded post discusses pregnenolone's inhibition of TLR4 and its role in reducing alcohol cravings through immune pathway modulation.
Source summary and thread relationship - @lowmegatron · 2026-05-07 original
Author quotes Ray Peat on pregnenolone's effects on cortisol and alcohol cravings, then presents a 2023 human study showing pregnenolone (300-500 mg/day) decreases stress- and alcohol cue-induced craving, reduces stress-induced anxiety, and normalizes HPA axis in individuals with alcohol use disorder.
Source summary and thread relationship - @lowmegatron · 2026-05-08 original
Author quotes Ray Peat on thyroid hormone T3 decline with aging and impact on steroid hormone production (pregnenolone and progesterone); presents human study showing pregnenolone reduces stress-induced alcohol cravings.
Source summary and thread relationship - @lowmegatron · 2026-05-08 original
Synthesis of research on estradiol as risk factor and progesterone/allopregnanolone as treatment options for cocaine use disorder in women; Ray Peat commentary on hormone effects on brain excitation and mental function.
Source summary and thread relationship - @lowmegatron · 2026-05-27 original
T3 active thyroid hormone combined with magnesium is a reliable treatment for insomnia, cramps, and anxiety, whether caused by fatigue, aging, or alcohol withdrawal.
Source summary and thread relationship - @lowmegatron · 2026-06-08 original
Personal anecdote of using topical progesterone to rapidly calm a severely distressed woman who had been drinking heavily and exhibiting aggressive behavior, after other supplements (magnesium, l-theanine, taurine) showed limited effect.
Source summary and thread relationship - @lowmegatron · 2026-06-24 original
Reports sex differences in cocaine use disorder related to female sex hormones; estradiol increases vulnerability while progesterone and allopregnanolone may reduce cocaine seeking; cites animal study on combination progesterone and atomoxetine treatment.
Source summary and thread relationship - @lowmegatron · 2026-06-30 original
Thyroid hormone may prevent fetal alcohol syndrome. Pregnant rats consuming alcohol had lower thyroid hormones; T4 supplementation to offspring reduced behavioral patterns associated with syndrome. Alcohol suppresses T4 and T3 in humans.
Source summary and thread relationship - @1immortals1 · 2026-07-11 original
Author presents NAC (n-acetyl cysteine) as only OTC supplement directly replenishing glutathione, the body's master antioxidant. Discusses mechanisms including detoxification, respiratory infection reduction, OCD and addiction modulation, liver protection, male fertility improvement, and neuroprotection. Recommends 600mg 1-2x daily on empty stomach.
Source summary and thread relationship - @lowmegatron · 2026-07-15 original
Ray Peat anecdote: two moles appeared and grew during summer beer consumption, then shrank and disappeared when beer stopped; attributed to estrogen content. Embedded Ray Peat quote on topical progesterone/DHEA and increased T3 causing mole shrinkage, and epsom salt baths.
Source summary and thread relationship - @lowmegatron · 2026-07-25 own thread
Quotes Ray Peat claiming the correct dose of T3 with magnesium is a reliable treatment for insomnia, cramps and anxiety from fatigue, aging or alcohol withdrawal.
Source summary and thread relationship - @lowmegatron · 2026-07-30 original
Sudden multiplication of moles is sign of hypothyroidism. Ray Peat anecdote: two moles appeared on forehead after drinking small amounts of Modelo beer daily for one summer; moles regressed rapidly after stopping beer consumption, with larger mole disappearing within 3 weeks. Peat attributes mole growth to beer's estrogen content and hypothyroidism connection.
Source summary and thread relationship - @lowmegatron · 2026-08-10 original
Pregnenolone may help reduce alcohol cravings and anxiety in alcohol use disorder. A Ray Peat anecdote describes an alcoholic man whose anxiety and depression lifted after taking pregnenolone, describing it as 'the feeling I've been trying to get from alcohol, but it never worked.' Alcohol's calming effects are mediated through pregnenolone, DHEA, allopregnanolone, and progesterone. A human study (2023) found pregnenolone (300–500 mg/day) reduces stress-induced and alcohol cue-induced craving and normalizes HPA axis function. Author recommends Balancedbodymind, Raena, and Forefront Health pregnenolone brands, cautioning that many brands produce bad effects.
Source summary and thread relationship - @lowmegatron · 2026-08-19 original
Ray Peat explains adrenaline compensation for low thyroid function dilates pupils. Levothyroxine works when liver has sufficient glucose and is not stressed by adrenaline. Combined T4+T3 formulations (Armour thyroid, Novotiral) superior to levothyroxine alone for stress hormone patterns. Cannabis interferes with liver function; recovery requires adequate protein and nutrients (orange juice, eggs, milk, cheese, cooked mushrooms, occasional shellfish).
Source summary and thread relationship - @lowmegatron · 2026-08-22 original
Pregnenolone mechanism for reducing alcohol drinking in animals and stress-induced alcohol craving in humans: increases allopregnanolone (GABA modulator). Mechanism depends on T3 and cholesterol. Recommends three specific brands with sourcing caution due to impurity risks.
Source summary and thread relationship - @lowmegatron · 2026-08-23 original
Ray Peat quoted on ethanol as antioxidant; embedded quote from World_All_Alive reports personal anecdotal use of small vodka doses for self-reported histamine issues.
Source summary and thread relationship - @lowmegatron · 2026-08-23 original
Pregnenolone downregulates endotoxin-related inflammation through degradation of TIRAP, TLR2, and TLR4 signaling; allopregnanolone (downstream metabolite) shows similar effects in cell culture and animal brain models related to multiple conditions.
Source summary and thread relationship - @lowmegatron · 2026-08-26 original
Correcting hypothyroidism and basal metabolic rate allows patients to tolerate alcohol without ill effects. Dr. Broda Barnes observed that hypothyroid patients unable to drink alcohol due to poor tolerance and hangover could drink freely once thyroid function was corrected. The embedded quoted post discusses pregnenolone's effects on alcohol cravings, stress, and HPA axis in individuals with alcohol use disorder.
Source summary and thread relationship - @lowmegatron · 2026-08-26 original
Individual differences in alcohol response depend on thyroid activity; alcohol has antioxidant effects but can cause hypoglycemia and pro-oxidative effects. Polyunsaturated fat (PUFA) increases alcohol's oxidative damage through iron-fat reactions. Saturated fat (clarified butter/MCT) reverses alcoholic liver injury better than unsaturated fat through reduced lipid peroxidation and gut barrier tightening. Saturated fat is not peroxidizable and reduces PUFA peroxidation. Thyroid hormone aids liver regeneration.
Source summary and thread relationship - @lowmegatron · 2026-08-28 original
Thyroid hormone accelerates alcohol detoxification and affects neurosteroid production (pregnenolone, DHEA, progesterone, allopregnanolone), which mediate anxiety relief and intoxication effects. Hyperthyroidism markedly increases ethanol metabolism rate.
Source summary and thread relationship - @lowmegatron · 2026-09-07 original
Bioidentical progesterone reduces anxiety and increases pro-social and exploratory behaviors in mice via increased allopregnanolone (5α-reductase metabolite); synthetic progestin (MPA) does not produce this effect because it does not serve as substrate for 5α-reductase. Neurosteroid effects may be relevant to sex differences in neuropsychiatric and neurodegenerative disorders. Embedded post discusses thyroid hormone's role in alcohol detoxification and neurosteroid production.
Source summary and thread relationship